Compare Supplements

Side-by-side comparison of 2 supplements

Bcx6.5

B-Complex

High safety

Tir7.8

Tirzepatide

Limited safety

Evidence

Evidence Score6.5/10

Studies: 54

Meta-analyses: 19

Evidence Score7.8/10

Studies: 13

Meta-analyses: 2

Dosage & timing

Dosage:

1.5capsules/day

Best Time:

Morning · with food

Take with food

Form:

Methylated B-complex (methylcobalamin, methylfolate)

Dosage:

Once-weekly subcutaneous injection, started at 2.5 mg and escalated by 2.5 mg every 4 weeks to a maintenance dose of 5, 10, or 15 mg (per the prescribing physician and approved indication)

Best Time:

Any time

Can take on empty stomach

Form:

Once-weekly subcutaneous injection (Mounjaro / Zepbound)

What you'll notice

⚡ More Energypositive

2-4 weeks

😊 Better Moodpositive

4-8 weeks

💛 Bright Yellow Urineneutral

Immediate

🩸 Strong glycemic controlpositive

Weeks to months

⚖️ Large weight losspositive

Months (dose-escalated over ~20 weeks)

😴 Reduced sleep-apnea severitypositive

Weeks to months

Safety

High safety

Contraindications:

Leber's disease (avoid high-dose B12)
Allergy to any B vitamin

Drug Interactions:

Levodopa
Methotrexate
Phenytoin

Side Effects:

NauseaBright yellow urineFlushing (high-dose niacin)

Limited safety

Contraindications:

Personal or family history of medullary thyroid carcinoma (MTC)
Multiple endocrine neoplasia syndrome type 2 (MEN2)
History of pancreatitis (use with caution / avoid)

Drug Interactions:

Oral contraceptives
Insulin and sulfonylureas
Oral medications generally

Side Effects:

NauseaDiarrheaVomiting

Works well with

Magnesium

complementary

Omega-3

stacks-well

5-HTP

enhances

No synergies listed

How they work together

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