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Nicotinamide Riboside

7.2/10high

Evidence

Evidence Score7.2/10

Studies: 28+

Meta-analyses: 5

Dosage & Timing

Dosage:

300–500 mg daily

Best Time:

Morning with breakfast, Split dosing (morning and midday) for doses above 500 mg

Take with food

Form:

Nicotinamide Riboside Chloride capsules or powder

What You'll Notice

📈 Elevated Blood NAD+ Levels95%

1–2 weeks

⚡ Improved Energy & Reduced Fatigue55%

4–8 weeks

🧠 Cognitive Stability45%

8–16 weeks

Safety

high safety rating

Contraindications:

Known hypersensitivity to nicotinamide riboside or niacin derivatives
Active cancer or cancer history: NAD+ elevation may theoretically support tumor cell metabolism (consult oncologist before use)
Severe hepatic impairment: high-dose NAD+ precursors may affect liver metabolism

Drug Interactions:

Chemotherapy agents
PARP inhibitors (e.g., olaparib, niraparib)
Alcohol

Side Effects:

NauseaHeadacheBloating or GI discomfort

Works Well With

Pterostilbeneenhances

Resveratrolcomplementary

CoQ10complementary

Compare Supplements

Nicotinamide Riboside

Evidence

Dosage & Timing

What You'll Notice

Safety

Works Well With

Categories

Compare Supplements

Nicotinamide Riboside

Evidence

Dosage & Timing

What You'll Notice

Safety

Works Well With

Categories