Compare Supplements

Side-by-side comparison of 1 supplements

🧬

SAMe

9/10moderate

Evidence

Evidence Score9/10

Studies: 40+

Meta-analyses: 32

Dosage & Timing

Dosage:

400-1600mg for mood; 600-1200mg for joints

Best Time:

On empty stomach, Morning and/or midday

Can take on empty stomach

Form:

Enteric-coated tablets (SAMe tosylate or butanedisulfonate)

What You'll Notice

😊 Mood Improvement65%

2-6 weeks

🦵 Joint Pain Relief60%

4-8 weeks

🫀 Liver Support55%

4-8 weeks

Safety

moderate safety rating

Contraindications:

Bipolar disorder (may trigger mania)
Parkinson's disease on levodopa

Drug Interactions:

Antidepressants (SSRIs, MAOIs, tricyclics)
Levodopa
Tramadol and other serotonergic drugs

Side Effects:

GI upset/nauseaAnxiety/restlessnessInsomnia

Works Well With

B-Complex (B12/Folate)enhances

Omega-3complementary

Compare Supplements

SAMe

Evidence

Dosage & Timing

What You'll Notice

Safety

Works Well With

Categories

Compare Supplements

SAMe

Evidence

Dosage & Timing

What You'll Notice

Safety

Works Well With

Categories