Mood Support Stack
Supplements studied for low mood — what the human trials actually show.
Strong stack — well-matched with minor gaps.
What's in this stack
- Saffron7.5/10 evidence
Beat placebo for depression in meta-analyses, and small trials found no significant difference versus SSRIs, which does not show equal effect. Also studied for anxiety and PMS symptoms.
Typical dose: 28-30mg daily
- Omega-39/10 evidence
Essential fatty acids critical for brain health, mood regulation, and reducing inflammation throughout the body.
Typical dose: 2-3g combined EPA+DHA daily (a typical label dose, not the dose used in the cited trials, which gave 1 g or 3.25 g of omega-3 a day, or 1 to 4 g of fish oil a day without stating its EPA+DHA content)
- Vitamin D37.5/10 evidence
Hormone-like vitamin that regulates 1,000+ genes — deficiency is widespread and linked to poor immunity, depression, and bone loss.
Typical dose: 2000-4000 IU daily
- 5-HTP5.5/10 evidence
Direct serotonin precursor that may support mood, sleep, and appetite control, but requires caution with certain medications.
Typical dose: 50-100mg for sleep; 150-300mg for mood (a typical label dose. The cited 100-300 mg study tested tolerability in 15 healthy men also given carbidopa, not mood)
What this stack covers
- Support mood79% · via Omega-3
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