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And7.0
Andrographis – Forschung
Hilft vermutlich
56 begutachtete Studien
Was die Evidenz sagt
Hilft vermutlich
Andrographis half in etwa der Hälfte (4/8) der Studien, die einen Effekt gemessen haben — vielversprechend, aber nicht einhellig.
Die meiste Evidenz stammt aus hochwertigen Meta-Analysen und randomisierten Studien, veröffentlicht 2002–2026 mit einer typischen Studiengröße von 103 Teilnehmenden.
Basierend auf 56 Studien · 4 Meta-Analysen · 25 RCTs · 8,165 Teilnehmende insgesamt
Konfidenz
Hohe Konfidenz
Was die Studien gefunden haben
4geholfen3unklar1nicht geholfen· 48 weitere ohne bewertete Effektdaten
Nach Outcome
Immune supportReduzierte Schwere und Dauer von Erkältungen/Grippe · 2-5 Tage bei Einnahme zu Beginn
Hilft vermutlich48 Studien
Therapeutic & clinical
Hilft vermutlich14 Studien
Safety profile
Überwiegend Mechanismus / Beobachtung6 Studien
Joint pain & arthritis
Überwiegend Mechanismus / Beobachtung4 Studien
Energy & fatigue
Überwiegend Mechanismus / Beobachtung3 Studien
InflammationStarke entzündungshemmende Wirkung über NF-kB-Hemmung · 1-2 Wochen
Zu wenige bewertete Studien2 Studien
Glucose & metabolic
Zu wenige bewertete Studien2 Studien
Heart & blood pressure
Zu wenige bewertete Studien1 Studie
In Zahlen
Aus 30 Studien mit messbaren Effekten gezogen
Wahrscheinlich echte Effekte
67%
über Studien hinweg
Untersuchte Personen
8,165
typische Studie: 103 Personen
Stärkste Designs
29
4 gepoolt, 25 randomisiert
Zeigte Nutzen
50%
4/8 Studien
Wie lange Studien liefen
Unter einer Woche
1
1–4 Wochen
1
1–3 Monate
2
3+ Monate
1
Untersuchte Populationen
COVID-19 patients2
Patients taking Andrographis paniculata1
Adults and children with acute respiratory tract infections1
IBD patients (mean age 41, 50% female)1
Aktives Forschungsgebiet
23 Studien in den letzten 5 Jahren · Neueste Meta-Analyse: 2024
200220142026
1Incidence of adverse eventsMeta-AnalyseCited 22×n=1,000 · large study2021
Like other medicine, Andrographis paniculata can cause some AEs.
Worakunphanich W et al. · Pharmacoepidemiology and drug safety (2021)
Kein klarer Effekt
← SchlechterKein EffektBesser →
Incidence of serious AEs was very rare with the pooled incidence (95% CI) from RCTs of 0.02 per 1000 patients (0.0-0.5).
However, the incidence of nonserious AEs was considered very common with the pooled incidence (95% CI) from RCTs of 102.6 per 1000 patients (10.7-256.1), and the pooled incidence (95% CI) from intensive monitoring of 34.2 per 1000 patients (0.0-229.6).
Like other medicine, Andrographis paniculata can cause some AEs.
3IBD treatment with herbal therapySystematische ÜbersichtCited 88×n=1,484 · large study2013
Randomised controlled trials of herbal therapy for the treatment of IBD show encouraging results but studies remain limited and heterogenous.
Ng SC et al. · Alimentary pharmacology & therapeutics (2013)
Twenty-one randomised controlled trials (14 UC; 7 CD) including a total of 1484 subjects (mean age 41, 50% female) were analysed.
Randomised controlled trials of herbal therapy for the treatment of IBD show encouraging results but studies remain limited and heterogenous.
Larger controlled studies with stricter endpoints and better-defined patient groups are required to obtain more conclusive results on the use of CAM therapies in IBD.
5Clinical response rates for ulcerative colitisMeta-AnalyseCited 16×2024
Research with larger scale and well-designed RCTs, manufacturing regulations, and education are needed.
Iyengar P et al. · Nutrients (2024)
Sehr groß Schaden
← SchlechterKein EffektBesser →
In pooled analyses, when compared with placebo, clinical response rates were significantly higher for Indigo naturalis (IN) (RR 3.70, 95% CI 1.97-6.95), but not for Curcuma longa (CL) (RR 1.60, 95% CI 0.99-2.58) or Andrographis paniculata (AP) (RR 0.95, 95% CI 0.71-1.26).
There was a significantly higher rate of clinical remission for CL (RR 2.58, 95% CI 1.18-5.63), but not for AP (RR 1.31, 95% CI 0.86-2.01).
Higher rates of endoscopic response (RR 1.56, 95% CI 1.08-2.26) and remission (RR 19.37, 95% CI 2.71-138.42) were significant for CL.
These studies indicate that andrographolide can hinder the cell cycle, suppress cell proliferation, alleviate oxidative stress, and induce apoptosis by prompting gastric cancer cells to undergo self-destruction, which is a crucial mechanism for controlling and eliminating cancerous growths.
Anis Amiera MA et al. · PeerJ (2024)
These studies indicate that andrographolide can hinder the cell cycle, suppress cell proliferation, alleviate oxidative stress, and induce apoptosis by prompting gastric cancer cells to undergo self-destruction, which is a crucial mechanism for controlling and eliminating cancerous growths.
7Therapeutic efficacy of andrographolide in cancerSystematische ÜbersichtCited 123×n=139 · medium study2018
Among the model systems, cultured cell lines appeared as the most frequently (79.14%) used, followed by in vivo models using rodents, among others.
Islam MT et al. · Cancer letters (2018)
Among the model systems, cultured cell lines appeared as the most frequently (79.14%) used, followed by in vivo models using rodents, among others.
After careful consideration of the relevant evidence, we suggest that andrographolide can be one of the potential agents in the treatment of cancer in the near future.
8Antimicrobial activity of andrographolideSystematische ÜbersichtCited 11×n=16 · very small study2024
This review highlights the need for further research on andrographolide's antifungal activity, mechanisms of action, clinical safety, toxicity, and potential applications in antimicrobial resistance strategies.
Dafur GS et al. · Journal of microbiology and biotechnology (2024)
The quality assessment revealed low bias risk in 11 out of 16 studies (78.57% to 92.86%), while the remaining five had medium bias risk (57.14% to 64.29%), indicating an overall acceptable quality of the studies.
Information on andrographolide's potential and effectiveness across various microorganisms is crucial.
Therefore, the purpose of this review was to synthesize the existing data on andrographolide's antimicrobial activity and assess its potential in combating antimicrobial resistance.
9Clinical and biological outcomes in multiple sclerosisSystematische ÜbersichtCited 12×n=31 · small study2020
The existing literature provides preliminary support for the use of a number of nutraceutical interventions in MS.
Marx W et al. · Multiple sclerosis and related disorders (2020)
The existing literature provides preliminary support for the use of a number of nutraceutical interventions in MS.
However, sufficiently powered long-term trials are required to expand the currently limited literature and to investigate unexplored nutraceuticals that may target relevant pathways involved in MS such as the gut microbiome and mitochondrial dysfunction.
11Disease activity in inflammatory bowel diseaseSystematische ÜbersichtCited 38×2016
In summary, attention to dietary factors such as curcumin, green tea and vitamins, including vitamins D and B12, appears to be beneficial and, if necessary, supplementation may be appropriate.
Rossi RE et al. · European journal of gastroenterology & hepatology (2016)
Zinc and iron should be supplemented in selected cases.
Probiotics (VSL#3) may reduce disease activity in IBD patients with pouchitis.
Complementary and alternative medicines are used by IBD patients and some studies have shown promising results.
Complementary and alternative therapies might be effective for the treatment of inflammatory bowel diseases; however, given the low number of trials and the heterogeneous methodological quality of trials, further in-depth research is necessary.
Langhorst J et al. · Journal of Crohn's & colitis (2015)
Complementary and alternative therapies might be effective for the treatment of inflammatory bowel diseases; however, given the low number of trials and the heterogeneous methodological quality of trials, further in-depth research is necessary.
18Resolution of upper respiratory tract infection symptomsRCTCited 3×n=331 · medium study2023
Participants in both the AP-Bio® dose groups showed positive tendency towards resolution of URTI symptoms when compared with placebo on Day-3 but not on Day-5 and Day-7.
Raj JP et al. · Complementary therapies in medicine (2023)
Spürbar Nutzen
← SchlechterKein EffektBesser →
Likely real
AP-Bio® 400 mg group (Mean Difference - MD [Standard Error - SE] = -3.85 [1.52]; 95% CI = -6.85, - 0.85; adjusted p = 0.034) and 200 mg group (MD [SE] = -3.74 [1.51]; 95% CI = -6.73, - 0.76; adjusted p = 0.038) had significantly lower score than placebo.
Participants in both the AP-Bio® dose groups showed positive tendency towards resolution of URTI symptoms when compared with placebo on Day-3 but not on Day-5 and Day-7.
Overall, it can be concluded that ParActin® in 300 and 600 mg/day dosages were found to be effective and safe in reducing pain in individuals suffering from mild to moderate knee osteoarthritis.
Hancke JL et al. · Phytotherapy research : PTR (2019)
Patients treated with 300 or 600 mg/day of ParActin® showed a significant reduction in pain at days 28, 56, and 84 compared with a placebo group.
WOMAC stiffness scores, physical function score, and the fatigue score showed a significant improvement in both ParActin®-treated groups compared with the placebo group.
At the end of the study, the quality of life (SF-36 questionnaire) and Functional Assessment of Chronic Illness Therapy (FACIT) scores showed significant improvements in both ParActin®-treated groups compared with the placebo group.
The combination of Guanxin Danshen Dropping Pill and Andrographis tablet exert significant anti-inflammatory effect on UA patients, which is superior to single Guanxin Danshen Dropping Pill. (Registration No.
Ma XJ et al. · Chinese journal of integrative medicine (2021)
The combination of Guanxin Danshen Dropping Pill and Andrographis tablet exert significant anti-inflammatory effect on UA patients, which is superior to single Guanxin Danshen Dropping Pill. (Registration No.