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An4.0
Aniracetam – Forschung
Überwiegend Mechanismus / Beobachtung
13 begutachtete Studien
Was die Evidenz sagt
Überwiegend Mechanismus / Beobachtung
Die meisten Studien zu Aniracetam sind mechanistisch oder beobachtend statt RCTs, die einen klinischen Effekt messen — betrachte die Ergebnisse als vorläufig.
Die meiste Evidenz stammt aus hochwertigen Meta-Analysen und randomisierten Studien, veröffentlicht 1987–2018 mit einer typischen Studiengröße von 166 Teilnehmenden.
Basierend auf 13 Studien · 1 Meta-Analyse · 8 RCTs · 45,493 Teilnehmende insgesamt
Einfach gesagt: Subgroup 1 drugs include piracetam, oxiracetam, aniracetam, pramiracetam and phenylpiracetam, which have been used in humans and some of which are available as dietary supplements.
Malykh AG, Sadaie MR · Drugs (2010)
Of the subgroup 1 racetams, oxiracetam and aniracetam are no longer in clinical use.
The modes of action of piracetam and most of its derivatives remain an enigma; differential effects on subtypes of glutamate receptors, but not the GABAergic actions, have been implicated.
Based on calculations of the efficacy rates, our assessments indicate notable improvements in clinical outcomes with some of these agents.
8Mild cognitive impairmentRCTn=166 · medium study2007
Einfach gesagt: Shenwu gelatin capsule has certain effects on mild cognitive impairment.
Zhong J et al. · Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica (2007)
Shenwu gelatin capsule has certain effects on mild cognitive impairment.
Further research warranted to confirm findings
9Cognitive behavior ability in vascular dementiaSystematische Übersichtn=88 · small study2014
Einfach gesagt: The scalp acupuncture combined with auricular point sticking could improve the clinical symptoms and cognitive behavior ability in patients with vascular dementia, which has superior total efficacy to body acupuncture and western medication aniracetam tablets.
Li SK et al. · Zhongguo zhen jiu = Chinese acupuncture & moxibustion (2014)
Sehr groß Nutzen
← SchlechterKein EffektBesser →
The total effective rate was 90.334 (28/31) in the combined therapy group, which was superior to 85.734 (24/28) in the body acupuncture group and 79.3% (23/29) in the western medication group (both P < 0.05).
The scalp acupuncture combined with auricular point sticking could improve the clinical symptoms and cognitive behavior ability in patients with vascular dementia, which has superior total efficacy to body acupuncture and western medication aniracetam tablets.
Further research warranted to confirm findings
10Clinical memory scale scoresRCTn=45 · small study2008
Einfach gesagt: Huannao Yicong capsule has better therapeutic effect than aniracetam capsule in treating senile mild cognitive impairment.
Li H et al. · Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine (2008)
Likely real
Other index scores of clinical memory scale and traditional Chinese medicine syndrome in patients of Huannao Yicong capsule-treated group were significantly improved as compared with those of the aniracetam-treated group (P<0.05, P<0.01).
Huannao Yicong capsule could significantly increase the activity of serum SOD and decrease the content of AchE, IL-1alpha and IL-6 (P<0.01, P<0.05), better than aniracetam.
Furthermore, Huannao Yicong capsule could significantly improve the blood lipid, such as the level of TG, LDL-C, HDL-C, ApoA-1 and ApoB-100 (P<0.01, P<0.05), and better than aniracetam (P<0.01, P<0.05).
11Mild cognitive impairment symptomsRCTn=64 · small study2010
Einfach gesagt: For treatment of MCI, HWD shows effects in improving patients' symptoms, cognition capacity and elevating serum Ach content better than that of Aniracetam; and with effects for raising SOD activity and reducing MDA level similar to those of Aniracetam.
Guo RZ et al. · Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine (2010)
For treatment of MCI, HWD shows effects in improving patients' symptoms, cognition capacity and elevating serum Ach content better than that of Aniracetam; and with effects for raising SOD activity and reducing MDA level similar to those of Aniracetam.
Further research warranted to confirm findings
12Cognitive impairmentBeobachtungsstudien=276 · medium study2012
Einfach gesagt: Our findings indicate that aniracetam (a nootropic compound with glutamatergic activity and neuroprotective potential) is a promising option for patients with cognitive deficit of mild severity.
Koliaki CC et al. · CNS neuroscience & therapeutics (2012)
In patients treated with aniracetam, all studied parameters were adequately maintained at 6 and 12 months, while emotional state was significantly improved at 3 months.
Our findings indicate that aniracetam (a nootropic compound with glutamatergic activity and neuroprotective potential) is a promising option for patients with cognitive deficit of mild severity.
It preserved all neuropsychological parameters for at least 12 months, and seemed to exert a favorable effect on emotional stability of demented patients.
Einfach gesagt: Despite several studies demonstrating efficacy in impaired subjects, our findings suggest that aniracetam does not alter behavior in normal healthy mice.
Elston TW et al. · PLoS One (2014)
Daily 50 mg/kg oral aniracetam was tested across spatial learning, associative learning, motor learning, odor discrimination, locomotion, and anxiety measures in naive C57BL/6J mice.
We detected no significant differences between the naive, placebo, and experimental groups across all measures.
Despite several studies demonstrating efficacy in impaired subjects, our findings suggest that aniracetam does not alter behavior in normal healthy mice.