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Bl73.0
B. longum 1714 – Forschung
Überwiegend Mechanismus / Beobachtung
9 begutachtete Studien
Was die Evidenz sagt
Überwiegend Mechanismus / Beobachtung
Die meisten Studien zu B. longum 1714 sind mechanistisch oder beobachtend statt RCTs, die einen klinischen Effekt messen — betrachte die Ergebnisse als vorläufig.
Die meiste Evidenz stammt aus mittelwertigen randomisierten Studien, veröffentlicht 2015–2026 mit einer typischen Studiengröße von 72 Teilnehmenden.
Basierend auf 9 Studien · 5 RCTs · 411 Teilnehmende insgesamt
Konfidenz
Mittlere Konfidenz
Nach Outcome
Stress & cortisolPossible reduction in self-reported stress, but the effect rests on a non-randomised 22-person study and was absent in a 20-student exam-stress trial · 4 weeks
Überwiegend Mechanismus / Beobachtung4 Studien
Sleep & well-beingSubjective sleep-quality components improved at 4 weeks in two trials, but the primary sleep endpoint was missed and objective actigraphy was unchanged · 4 weeks
Überwiegend Mechanismus / Beobachtung4 Studien
Mood & depressive symptomsNo established benefit — the dedicated 168-person depression trial missed its primary endpoint at both timepoints · 8 weeks
Überwiegend Mechanismus / Beobachtung3 Studien
Cognition & neurocognition
Überwiegend Mechanismus / Beobachtung3 Studien
EEG & brain-activity biomarkers
Überwiegend Mechanismus / Beobachtung3 Studien
Immune & tryptophan metabolism
Zu wenige bewertete Studien2 Studien
Aktives Forschungsgebiet
5 Studien in den letzten 5 Jahren
201520202026
1RCTn=89 · small study2024
Einfach gesagt: The dedicated sleep trial missed its primary endpoint, and objective actigraphy found no effect on sleep at all.
Patterson E et al. · Sci Rep (2024)
PRIMARY ENDPOINT MISSED: PSQI global score improved in both groups, with no significant advantage for the strain
Secondary subjective outcomes were significant: PSQI sleep-quality component and daytime dysfunction at 4 weeks, social functioning and energy/vitality at 8 weeks (all p<0.05)
OBJECTIVE MEASURE NULL: no significant effect on any actigraphy measure
Einfach gesagt: The largest trial of this strain, in 168 adults with mild-to-moderate depression, missed its primary endpoint at both week 4 and week 8.
Seamans KM et al. · Exp Clin Psychopharmacol (2026)
PRIMARY ENDPOINT MISSED: BDI-II change vs placebo was -0.303 (95% CI -1.957 to 1.35, p=.718) at week 4 and -1.432 (95% CI -3.30 to 0.44, p=.132) at week 8
Week-4 secondary outcomes PSQI total (-0.923, 95% CI -1.62 to -0.23, p=.009) and PHQ-9 (-1.013, 95% CI -2.00 to -0.02, p=.045) did NOT hold at week 8
SF-36 subscores improved at week 4 (vitality p=.038, mental health p=.032, social role functioning p=.033); only vitality remained significant at week 8 (p=.042)
Einfach gesagt: Brain oscillations changed on magnetoencephalography, but the trial states plainly that there was no effect at the behavioural level.
Wang H et al. · Am J Gastroenterol (2019)
Increased theta band power in frontal and cingulate cortex and decreased beta-3 band power in hippocampus, fusiform and temporal cortex (both P<0.05), correlating with subjective vitality
EXPLICIT BEHAVIOURAL NULL: all groups showed increased social stress after 4 weeks 'without an effect at behavioral level due to small sample numbers'
After the Cyberball social-stress paradigm, only the probiotic group showed altered neural oscillation (increased frontal/cingulate theta and alpha, and supramarginal gyrus, P<0.05)
Einfach gesagt: The mechanistic case: a strain-specific exopolysaccharide that induces IL-10, plus tryptophan and indole lactic acid that damp down TLR signalling.
Groeger D et al. · Curr Res Microb Sci (2025)
The strain produces a branched hexasaccharide repeating-unit exopolysaccharide that selectively induces IL-10 secretion from human PBMCs
It also produces tryptophan and indole lactic acid in vitro; indole lactic acid directly reduced TLR-induced pro-inflammatory cytokine secretion and NF-kB activation
Consumption reduced excessive cytokine responses in LPS-induced, stress-induced and obesity-induced inflammation in MOUSE models
Einfach gesagt: The paper that made this strain famous is not a randomised controlled trial — placebo always came first, so its findings cannot be separated from order effects.
Allen AP et al. · Transl Psychiatry (2016)
PubMed classifies this as a Controlled Clinical Trial, NOT a Randomized Controlled Trial
Within-participants design in 22 healthy volunteers: assessments at baseline, then post-placebo, then post-psychobiotic — placebo ALWAYS preceded the probiotic
No randomisation of order and no parallel placebo arm, so improvements are confounded with repeated testing and expectancy