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B5.5
Boron – Forschung
Überwiegend Mechanismus / Beobachtung
37 begutachtete Studien
Was die Evidenz sagt
Überwiegend Mechanismus / Beobachtung
Die meisten Studien zu Boron sind mechanistisch oder beobachtend statt RCTs, die einen klinischen Effekt messen — betrachte die Ergebnisse als vorläufig.
Die meiste Evidenz stammt aus hochwertigen randomisierten Studien, veröffentlicht 1993–2026 mit einer typischen Studiengröße von 29 Teilnehmenden.
Basierend auf 37 Studien · 13 RCTs · 593 Teilnehmende insgesamt
Konfidenz
Mittlere Konfidenz
Nach Outcome
Bone healthUnterstützt die Knochenmineraldichte und die Skelettstärke · 8-12 Wochen
Überwiegend Mechanismus / Beobachtung33 Studien
Men's vitalityModuliert das freie Testosteron und den Östrogenstoffwechsel · 2-4 Wochen · Moderate Erhöhung des freien Testosterons · 4-8 Wochen
Überwiegend Mechanismus / Beobachtung5 Studien
InflammationUnterstützt die Knochendichte und die Gelenkgesundheit · Fortlaufend
Überwiegend Mechanismus / Beobachtung4 Studien
Women's healthUnterstützt einen gesunden Östrogenstoffwechsel und das hormonelle Gleichgewicht · 4-8 Wochen
Überwiegend Mechanismus / Beobachtung3 Studien
Cognitive function
Zu wenige bewertete Studien2 Studien
Therapeutic & clinical
Zu wenige bewertete Studien2 Studien
Safety profile
Zu wenige bewertete Studien2 Studien
Joint pain & arthritisUnterstützt die Gelenkgesundheit und reduziert Arthrose-Symptome bei einem Mangel · 4-8 Wochen
Zu wenige bewertete Studien1 Studie
In Zahlen
Aus 16 Studien mit messbaren Effekten gezogen
Wahrscheinlich echte Effekte
100%
über Studien hinweg
Untersuchte Personen
593
typische Studie: 29 Personen
Stärkste Designs
13
0 gepoolt, 13 randomisiert
Untersuchte Populationen
General population2
Agricultural crops1
Humans and animals1
osteopenia/osteoporosis patients1
Aktives Forschungsgebiet
23 Studien in den letzten 5 Jahren
199320092026
1Systematische Übersichtn=29 · very small study2019
Heffernan SM et al. · Nutrients (2019)
Approximately 50% of athletes have reported consuming some form of micronutrient supplement; however, there is limited data confirming their efficacy for improving performance.
Only Iron and Magnesium included articles of sufficient quality to be assigned as 'strong'.
Currently, there is little evidence to support the use of MTE supplementation to improve physiological markers of athletic performance, with the possible exception of Iron (in particular, biological situations) and Magnesium as these currently have the strongest quality evidence.
Einfach gesagt: The roles of primary nutrients (nitrogen, phosphorous and potassium), secondary nutrients (calcium, magnesium and sulphur), micronutrients (zinc, boron, iron and copper), and beneficial nutrients (cobalt, selenium and silicon) in alleviating abiotic stress in crop plants are discussed.
Kumari VV et al. · International journal of molecular sciences (2022)
Abiotic stress during the reproductive stage results in flower drop, pollen sterility, pollen tube deformation, ovule abortion, and reduced yield.
Plant nutrition is one of the most effective ways of reducing abiotic stress in agricultural crops.
In this paper, we have discussed the effectiveness of different nutrients for alleviating abiotic stress.
3Boron essentiality in microbiota symbiosisÜbersicht2022
Einfach gesagt: This paper reviews the evidence supporting the essentiality of the NOB species in the symbiosis between the microbiota and the human/animal hosts, with the stated aim of highlighting the MoA and targets of these species.
Biţă A et al. · International journal of molecular sciences (2022)
New insights into the key role of NOB species in the symbiosis between human/animal hosts and their microbiota will influence the use of natural B-based colon-targeting nutraceuticals.
The mechanism of action (MoA) of NOB species is related to the B signaling molecule (autoinducer-2-borate (AI-2B)) as well as the fortification of the colonic mucus gel layer with NOB species from B-rich prebiotic diets.
Both the microbiota and the colonic mucus gel layer can become NOB targets.
4bone mineral density loss preventionÜbersicht2021
Einfach gesagt: Finally, three to four times per week of 30-40 min of aerobic and resistance exercises must be performed.
Rondanelli M et al. · Nutrients (2021)
Given this background, aim of this review is to evaluate the latest data regarding ideal dietary approach in order to reduce bone mineral density loss and to construct a food pyramid that allows osteopenia/osteoporosis patients to easily figure out what to eat.
Finally, three to four times per week of 30-40 min of aerobic and resistance exercises must be performed.
5Trace elements role in joint diseasesÜbersicht2025
Einfach gesagt: We also discuss their potential application in the treatment of joint diseases.
Bryliński Ł et al. · International journal of molecular sciences (2025)
We describe the molecular mechanisms that explain their interaction with chondrocytes, osteocytes, osteoblasts, osteoclasts, and synoviocytes, as well as their proliferation, apoptosis, and extracellular matrix synthesis.
We also focus on the role of these trace elements in the pathogenesis of joint diseases: rheumatoid arthritis (RA), osteoarthritis (OA), psoriatic arthritis (PsA), ankylosing spondylitis (AS), and systemic lupus erythematosus (SLE).
We describe the roles of increased or decreased concentrations of individual elements in the pathogenesis and development of joint diseases and their impact on inflammation and disease progression, referring to molecular mechanisms.
6Metabolic regulation, neurobiology, and bone healthÜbersicht2026
Einfach gesagt: Although Li-Si-B display compelling mechanistic potential, current human data are insufficient to justify dietary recommendations or supplementation.
Melenikioti E et al. · Nutrients (2026)
Although Li-Si-B display compelling mechanistic potential, current human data are insufficient to justify dietary recommendations or supplementation.
Considerable research gaps-including exposure assessment, dose-response characterization, toxicity thresholds, and controlled human trials-must be addressed before translation into public health policy.
16Medical expulsive therapy efficacyRCTn=81 · small study2023
Einfach gesagt: Boron supplement could be effective as adjuvant medical expulsive therapy after ESWL with no significant side effects in short-term follow-up.
Jalali S et al. · Biological trace element research (2023)
No Significant side effects were reported in the two groups.
Boron supplement could be effective as adjuvant medical expulsive therapy after ESWL with no significant side effects in short-term follow-up.
19Clinical and biochemical parameters in COVID-19RCTn=19 · very small study2022
Einfach gesagt: Supplementation with boron citrate alone or in combination with oleoylethanolamide could improve some clinical and biochemical parameters in COVID-19 patients.
Akbari N et al. · Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) (2022)
Likely real
Supplementation with boron citrate alone or in combination with oleoylethanolamide significantly improved O2 saturation and respiratory rate (p < 0.01).
At the end of the study, significant increases in white blood cell and lymphocyte count were observed in the boron citrate and combined groups (p < 0.001).
Boron citrate supplementation led to a significant decrease in serum lactate dehydrogenase (p = 0.026) and erythrocyte sedimentation rate (p = 0.014), compared with other groups.
20prevention of non-target organ toxicity induced by ACTÜbersicht2024
Einfach gesagt: In summary, TEs and their NPs present a promising avenue as adjuvant agents for preventing non-target organ toxicity induced by ACT.
Famurewa AC et al. · Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine (2024)
However, evidence regarding the roles of lncRNA and the Wnt/β-catenin pathway in ACT toxicity remains inconsistent, and the impact of TEs and NPs on ACT efficacy is not fully understood.
Further research is needed to confirm the protective effects of TEs and their NPs against ACT toxicity in cancer patients.
In summary, TEs and their NPs present a promising avenue as adjuvant agents for preventing non-target organ toxicity induced by ACT.