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B5.5
Boron – Forschung
Überwiegend Mechanismus / Beobachtung
37 begutachtete Studien
Was die Evidenz sagt
Überwiegend Mechanismus / Beobachtung
Die meisten Studien zu Boron sind mechanistisch oder beobachtend statt RCTs, die einen klinischen Effekt messen — betrachte die Ergebnisse als vorläufig.
Die meiste Evidenz stammt aus hochwertigen randomisierten Studien, veröffentlicht 1994–2026 mit einer typischen Studiengröße von 29 Teilnehmenden.
Basierend auf 37 Studien · 4 RCTs · 608 Teilnehmende insgesamt
Konfidenz
Mittlere Konfidenz
Nach Outcome
Bone healthUnterstützt die Knochenmineraldichte und die Skelettstärke · 8-12 Wochen
Überwiegend Mechanismus / Beobachtung31 Studien
Therapeutic & clinical
Überwiegend Mechanismus / Beobachtung7 Studien
Men's vitalityModuliert das freie Testosteron und den Östrogenstoffwechsel · 2-4 Wochen · Moderate Erhöhung des freien Testosterons · 4-8 Wochen
Überwiegend Mechanismus / Beobachtung4 Studien
InflammationUnterstützt die Knochendichte und die Gelenkgesundheit · Fortlaufend
Überwiegend Mechanismus / Beobachtung4 Studien
Women's healthUnterstützt einen gesunden Östrogenstoffwechsel und das hormonelle Gleichgewicht · 4-8 Wochen
Überwiegend Mechanismus / Beobachtung3 Studien
Cognitive function
Zu wenige bewertete Studien2 Studien
Joint pain & arthritisUnterstützt die Gelenkgesundheit und reduziert Arthrose-Symptome bei einem Mangel · 4-8 Wochen
Zu wenige bewertete Studien1 Studie
Safety profile
Zu wenige bewertete Studien1 Studie
In Zahlen
Aus 16 Studien mit messbaren Effekten gezogen
Wahrscheinlich echte Effekte
100%
über Studien hinweg
Untersuchte Personen
608
typische Studie: 29 Personen
Stärkste Designs
4
0 gepoolt, 4 randomisiert
Untersuchte Populationen
General population2
Patients with joint diseases1
Agricultural crops1
Humans and animals1
Aktives Forschungsgebiet
32 Studien in den letzten 5 Jahren
199420102026
1Systematische ÜbersichtCited 61×n=29 · very small study2019
PROSPERO preregistered (CRD42018090502).
Heffernan SM et al. · Nutrients (2019)
Approximately 50% of athletes have reported consuming some form of micronutrient supplement; however, there is limited data confirming their efficacy for improving performance.
Only Iron and Magnesium included articles of sufficient quality to be assigned as 'strong'.
Currently, there is little evidence to support the use of MTE supplementation to improve physiological markers of athletic performance, with the possible exception of Iron (in particular, biological situations) and Magnesium as these currently have the strongest quality evidence.
2Metabolic regulation, neurobiology, and bone healthSystematische Übersicht2026
Although Li-Si-B display compelling mechanistic potential, current human data are insufficient to justify dietary recommendations or supplementation.
Melenikioti E et al. · Nutrients (2026)
Although Li-Si-B display compelling mechanistic potential, current human data are insufficient to justify dietary recommendations or supplementation.
Considerable research gaps-including exposure assessment, dose-response characterization, toxicity thresholds, and controlled human trials-must be addressed before translation into public health policy.
3Trace elements role in joint diseasesSystematische Übersicht2025
We also discuss their potential application in the treatment of joint diseases.
Bryliński Ł et al. · International journal of molecular sciences (2025)
We describe the molecular mechanisms that explain their interaction with chondrocytes, osteocytes, osteoblasts, osteoclasts, and synoviocytes, as well as their proliferation, apoptosis, and extracellular matrix synthesis.
We also focus on the role of these trace elements in the pathogenesis of joint diseases: rheumatoid arthritis (RA), osteoarthritis (OA), psoriatic arthritis (PsA), ankylosing spondylitis (AS), and systemic lupus erythematosus (SLE).
We describe the roles of increased or decreased concentrations of individual elements in the pathogenesis and development of joint diseases and their impact on inflammation and disease progression, referring to molecular mechanisms.
4Abiotic stress alleviation in cropsSystematische Übersicht2022
The roles of primary nutrients (nitrogen, phosphorous and potassium), secondary nutrients (calcium, magnesium and sulphur), micronutrients (zinc, boron, iron and copper), and beneficial nutrients (cobalt, selenium and silicon) in alleviating abiotic stress in crop plants are discussed.
Kumari VV et al. · International journal of molecular sciences (2022)
Abiotic stress during the reproductive stage results in flower drop, pollen sterility, pollen tube deformation, ovule abortion, and reduced yield.
Plant nutrition is one of the most effective ways of reducing abiotic stress in agricultural crops.
In this paper, we have discussed the effectiveness of different nutrients for alleviating abiotic stress.
5Boron essentiality in microbiota symbiosisSystematische Übersicht2022
This paper reviews the evidence supporting the essentiality of the NOB species in the symbiosis between the microbiota and the human/animal hosts, with the stated aim of highlighting the MoA and targets of these species.
Biţă A et al. · International journal of molecular sciences (2022)
New insights into the key role of NOB species in the symbiosis between human/animal hosts and their microbiota will influence the use of natural B-based colon-targeting nutraceuticals.
The mechanism of action (MoA) of NOB species is related to the B signaling molecule (autoinducer-2-borate (AI-2B)) as well as the fortification of the colonic mucus gel layer with NOB species from B-rich prebiotic diets.
Both the microbiota and the colonic mucus gel layer can become NOB targets.
6bone mineral density loss preventionSystematische Übersicht2021
Finally, three to four times per week of 30-40 min of aerobic and resistance exercises must be performed.
Rondanelli M et al. · Nutrients (2021)
Given this background, aim of this review is to evaluate the latest data regarding ideal dietary approach in order to reduce bone mineral density loss and to construct a food pyramid that allows osteopenia/osteoporosis patients to easily figure out what to eat.
Finally, three to four times per week of 30-40 min of aerobic and resistance exercises must be performed.
9Clinical and biochemical parameters in COVID-19RCTCited 19×n=19 · very small study2022
Supplementation with boron citrate alone or in combination with oleoylethanolamide could improve some clinical and biochemical parameters in COVID-19 patients.
Akbari N et al. · Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) (2022)
Likely real
Supplementation with boron citrate alone or in combination with oleoylethanolamide significantly improved O2 saturation and respiratory rate (p < 0.01).
At the end of the study, significant increases in white blood cell and lymphocyte count were observed in the boron citrate and combined groups (p < 0.001).
Boron citrate supplementation led to a significant decrease in serum lactate dehydrogenase (p = 0.026) and erythrocyte sedimentation rate (p = 0.014), compared with other groups.
Critically, BNCT, with its unique dual-targeting mechanism, represents a potentially transformative precision therapy with significant potential for intractable malignancies.
Yao H et al. · Molecular pharmaceutics (2026)
This review delineates the latest progress in particle radiotherapy, specifically highlighting the crucial transition from the established physical targeting of PT and CIRT to the burgeoning dual-targeting innovation of BNCT.
We provide an in-depth analysis of mechanistic principles, technological advancements in accelerator-based sources, the pharmacological evolution of boron delivery systems, and the resulting clinical applications.
Future directions for the entire particle radiotherapy field center on reducing operational costs, optimizing therapeutic accuracy, conducting robust randomized trials, and exploring synergistic therapies.
We identify key knowledge gaps and experimental priorities (speciation-aware measurements, signal-centric readouts) necessary to determine when, where, and how B-mediated molecular architecture may counteract DYS and support healthspan.
Mogoşanu GD, Biţă A, Scorei IR, Pop MI, Dinu IR, Gheonea DI. · Life (Basel, Switzerland) (2026)
Central to this model is spatial bioavailability, distinguishing plasma-accessible boron from microbiota-accessible boron (MAB), species that persist in the lumen and mucus layer long enough to influence interface-level processes.
We propose that insufficient or altered MAB availability may contribute to dysbiosis (DYS) by destabilizing quorum-associated coordination, signal persistence, and mucosal microstructure, thereby promoting barrier dysfunction and inflammaging.
Particular attention is given to B-mediated symbiotaxis, a hypothesis-driven concept describing how B-containing molecular assemblies may bias microbial communities toward cooperative, barrier-supportive configurations and reduce ecological volatility.
This systematic-review examined the effects of Boron.
Nielsen FH. · Biological trace element research (2026)
Research findings are presented on the nutritional importance of aluminum, arsenic, boron, chromium, copper, iron, lead, magnesium, manganese, nickel, selenium, silicon, tin, vanadium, and zinc.
Published in Biological trace element research (2026)
While the examples presented here utilize the fluorine in both the design and imaging element of a single theranostic agent, complementing techniques, such as 19F-NMR with cryo-EM for fragment-based drug discovery, provide a compelling path for more efficient drug discovery.
Richardson P · Expert opinion on drug discovery (2026)
Systematic review examining Boron efficacy
Published in Expert opinion on drug discovery (2026)
This review also highlights existing gaps and future directions for designing superior 2D-NM-based sensing systems aimed at combating antibiotic pollution and safeguarding public health.
Sharda P et al. · Nanoscale (2026)
This review comprehensively discusses the development of electrochemical sensors and biosensors based on 2D-NMs, such as graphene oxide (GO), MXenes, layered double hydroxides (LDHs), and boron nitrides (BN) for antibiotic detection.
It emphasizes performance metrics including limit of detection (LOD), linear range, response time, reproducibility, and operational feasibility.
Furthermore, it explores the integration of 2D-NMs with emerging technologies, including microfluidics, screen-printed electrodes, laser-induced sensors, and AI for next-generation POC platforms.
By detailing the current status of novel boron-10 carriers, this review further aims to elucidate critical challenges and opportunities in BNCT drug development, ultimately providing a theoretical foundation for next-generation BNCT interventions.
Tang D, Shi M, Mao Z, Chen W, Li X, Zhao XY, Liu Z, Xu X. · Precision radiation oncology (2026)
These challenges have stimulated extensive global research into novel boron-10 carriers and innovative carrier platforms, including amino acids, sugars, porphyrin derivatives, nucleotides, and a variety of nanocarrier systems.
This review provides a systematic classification of high-abundance boron-10 carriers, critically examines radio-boron research, and evaluates the potential integration of BNCT into clinical diagnostics and advanced cancer treatment protocols.
By detailing the current status of novel boron-10 carriers, this review further aims to elucidate critical challenges and opportunities in BNCT drug development, ultimately providing a theoretical foundation for next-generation BNCT interventions.
This systematic-review examined the effects of Boron.
Chen C, Yang M, Wang J, Zhang L, Huang S, Xu X, Liu Y. · Precision radiation oncology (2026)
Systematic review examining Boron efficacy
Published in Precision radiation oncology (2026)
Further research warranted to confirm findings
18Systematische Übersicht2026
This review provides an integrated perspective on how dimensional expansion and structural design govern the optical and electrical properties of boron-based nanomaterials.
Kawaguchi J, Kambe T. · Nanomaterials (Basel, Switzerland) (2026)
Low-dimensional (0D/1D/2D) nanomaterials exhibit unique physical and chemical properties different from general bulk materials due to enhanced surface and interface contributions and quantum confinement effects, which strongly modulate electronic structures.
Boron, with atomic number 5, can form multicenter bonds and enables the construction of structurally diverse nanomaterials across different dimensionalities.
In this review, boron-based low-dimensional materials are systematically organized from 0D clusters to 1D nanostructures and 2D sheets, and their optical and electrical properties are discussed in relation to structural factors such as dimensionality.
This systematic-review examined the effects of Boron.
Tang D, Shi M, Mao Z, Chen W, Li X, Zhao X, Liu Z, Xu X. · Precision radiation oncology (2026)
Systematic review examining Boron efficacy
Published in Precision radiation oncology (2026)
Further research warranted to confirm findings
20Systematische Übersicht2026
This review summarizes the current knowledge of a variety of potential targets for 10 B transport in BNCT.
Wei Y, Zhu W, Chen Q, Alnufaei H, Li Y, Ricketts K. · Frontiers in oncology (2026)
These species are short range (4-10 μm, less than a cell diameter) and therefore offer potential to kill cancer cells selectively and spare surrounding healthy cells if the 10 B drug can be targeted specifically and sufficiently to cancer cells.
Numerous studies have explored the role of selected targets on the influence of 10 B transport to make progress in developing novel, safe and effective 10 B carriers.
These findings would expand the clinical BNCT services to more patients, with potential to make BNCT a more precise and effective treatment modality for various types of cancer.