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Cen5.0
Centella Asiatica (Cica) – Forschung
Überwiegend Mechanismus / Beobachtung
12 begutachtete Studien
Was die Evidenz sagt
Überwiegend Mechanismus / Beobachtung
Die meisten Studien zu Centella Asiatica (Cica) sind mechanistisch oder beobachtend statt RCTs, die einen klinischen Effekt messen — betrachte die Ergebnisse als vorläufig.
Die meiste Evidenz stammt aus mittelwertigen Meta-Analysen und randomisierten Studien, veröffentlicht 1996–2026 mit einer typischen Studiengröße von 60 Teilnehmenden.
Basierend auf 12 Studien · 2 Meta-Analysen · 2 RCTs · 2,521 Teilnehmende insgesamt
Konfidenz
Hohe Konfidenz
Nach Outcome
Skin healthBeruhigt, lindert Rötungen und unterstützt die Hautbarriere — die am besten belegte Anwendung (kosmetisch, kein gesundheitlicher Endpunkt) · 2-12 Wochen · Mögliche Verbesserung von Falten/Festigkeit durch Kollagenstimulation, gezeigt in einer kleinen Kombinationsstudie (kosmetisch) · 12-24 Wochen
Überwiegend Mechanismus / Beobachtung3 Studien
Wound & ulcer healing
Zu wenige bewertete Studien2 Studien
Energy & fatigue
Zu wenige bewertete Studien1 Studie
Women's health
Zu wenige bewertete Studien1 Studie
Safety profile
Zu wenige bewertete Studien1 Studie
Longevity & aging
Zu wenige bewertete Studien1 Studie
Hair & nails
Zu wenige bewertete Studien1 Studie
Aktives Forschungsgebiet
8 Studien in den letzten 5 Jahren · Neueste Meta-Analyse: 2026
199620112026
1Meta-Analysen=1,216 · large study2026
Permethrin demonstrates a modest advantage over ivermectin in achieving clinical cure and reducing treatment failure.
Innocent DC et al. · BMC infectious diseases (2026)
Compared with permethrin, ivermectin was associated with a lower probability of clinical cure at final follow-up (RR = 0.93, 95% CI 0.86-0.99; I² = 61%) and a higher risk of treatment failure (RR = 1.52, 95% CI 1.06-2.20; I² = 0%).
Permethrin demonstrates a modest advantage over ivermectin in achieving clinical cure and reducing treatment failure.
Ivermectin remains a useful alternative where topical therapy is unsuitable, but optimised dosing regimens are essential.
Abdelkader SI, Aboelenin SA, Abdelhafez RA, Nabhan AF. · BMC women's health (2026)
The evidence for all outcomes was very uncertain due to serious methodological concerns and imprecision.
CONCLUSIONS: The evidence is very uncertain about the benefits and harms of oral versus topical antifungal maintenance therapy for women with recurrent vulvovaginal candidiasis.
Given the substantial personal and healthcare burden of the condition, the uncertainty of the evidence leaves a crucial gap in guidance for clinicians and patients when choosing a maintenance strategy.
Congruence between policymakers, researchers, and public health professionals on the definition of PCH and PCC may address research operationalisation and clinical implementation to better assess global uptake and impact.
Chingara O et al. · Human reproduction update (2026)
Dermatologists may consider implementation of expert panel recommendations for treatment of AKs, SCCIS, and sBCC with 5-FU/C while awaiting larger, high-quality studies.
Loranger N et al. · Journal of the American Academy of Dermatology (2026)
A 70% or higher concordance among respondents represented consensus.
Dermatologists may consider implementation of expert panel recommendations for treatment of AKs, SCCIS, and sBCC with 5-FU/C while awaiting larger, high-quality studies.
After 6 months of treatment, we observed a significant improvement of the clinical score for deep and superficial wrinkles, suppleness, firmness, roughness and skin hydration.
Haftek M, Mac-Mary S, Le Bitoux MA, Creidi P, et al. · Exp Dermatol (2008)
Randomized double-blind study (n=20) of topical 5% vitamin C + 0.1% madecassoside on photoaged skin over 6 months
Significant improvement in deep/superficial wrinkles, suppleness, firmness, roughness, and hydration, with histologic elastic-fibre remodeling
Madecassoside was co-formulated with vitamin C and n was small — its independent effect is not isolated
There were no clinically significant differences in time to lesion healing, erythema, or oozing/crusting between groups. On day 21, 100% of patients agreed that their lesions had improved.
Lynde CW, Andriessen A, Guenther L, Dayeh N, et al. · J Drugs Dermatol (2025)
RCT (n=60) after cryotherapy for actinic keratoses: a non-prescription balm with panthenol, madecassoside, and metal salts vs a topical antibiotic
Madecassoside-containing balm gave wound healing equivalent to the antibiotic, with 100% reporting improvement by day 21 and no related adverse events
Non-inferiority design and a multi-ingredient balm — supports soothing/healing, but not centella in isolation
C. asiatica might enhance wound healing resulting from improved angiogenesis. This might occur due to its stimulating effect on collagen I, Fibroblast Growth Factor (FGF) and Vascular Endothelial Growth Factor (VEGF) production.
Arribas-López E, Zand N, Ojo O, Snowden MJ, et al. · Int J Environ Res Public Health (2022)
PRISMA systematic review identified only four clinical trials meeting inclusion criteria — a small human evidence base
Centella may enhance wound healing via improved angiogenesis and collagen I/FGF/VEGF stimulation, with anti-inflammatory effects
Authors state more studies are needed to perform a meta-analysis and ascertain effects
Preclinical evidence further indicates attenuation of cellular senescence, improvement of mitochondrial function, enhanced collagen synthesis, and regulation of cytokine production. However, clinical translation remains limited due to insufficient randomized controlled trials.
Borowicz KK. · Nutrients (2026)
Review of centella triterpenes' antioxidant, anti-inflammatory, and regenerative activity (NF-κB, PI3K/Akt/mTOR, Nrf2/HO-1, TGF-β/Smad signaling)
Preclinical evidence indicates enhanced collagen synthesis and attenuated cellular senescence relevant to skin aging
Explicitly notes clinical translation is limited by insufficient RCTs and variable extract standardization
Low dose of TECA did not exhibit toxicity and showed a protective effect against UVB irradiation in NDHFs.
An IS, An S, Kang SM, Choe TB, et al. · Int J Mol Med (2012)
In cultured human dermal fibroblasts, titrated centella extract (asiatic/madecassic acid, asiaticoside, madecassoside) protected against UVB damage at non-toxic doses
Altered microRNA profiles linked to cell proliferation and anti-apoptosis, suggesting a photoprotective mechanism
In-vitro only — establishes plausible mechanism, not a clinical effect