Wir verwenden standardmäßig essenzielle Cookies (Anmeldung, deine gespeicherten Ziele/Stacks). Mit deiner Erlaubnis aktivieren wir außerdem datenschutzfreundliche Analytik (Vercel Web Analytics, anonyme Ladezeit-Metriken) und Fehler-Replay-Diagnostik (Sentry — DOM-Snapshots nur, wenn ein Fehler auftritt), damit wir Bugs schneller beheben können. Mehr über Cookies erfahren
Cen5.0
Centella Asiatica (Cica) – Forschung
Überwiegend Mechanismus / Beobachtung
17 begutachtete Studien
Was die Evidenz sagt
Überwiegend Mechanismus / Beobachtung
Die meisten Studien zu Centella Asiatica (Cica) sind mechanistisch oder beobachtend statt RCTs, die einen klinischen Effekt messen — betrachte die Ergebnisse als vorläufig.
Die meiste Evidenz stammt aus mittelwertigen Meta-Analysen und randomisierten Studien, veröffentlicht 1996–2026 mit einer typischen Studiengröße von 60 Teilnehmenden.
Basierend auf 17 Studien · 3 Meta-Analysen · 8 RCTs · 7,313 Teilnehmende insgesamt
Konfidenz
Hohe Konfidenz
Nach Outcome
Skin healthBeruhigt, lindert Rötungen und unterstützt die Hautbarriere — die am besten belegte Anwendung (kosmetisch, kein gesundheitlicher Endpunkt) · 2-12 Wochen · Mögliche Verbesserung von Falten/Festigkeit durch Kollagenstimulation, gezeigt in einer kleinen Kombinationsstudie (kosmetisch) · 12-24 Wochen
Überwiegend Mechanismus / Beobachtung4 Studien
Wound & ulcer healing
Überwiegend Mechanismus / Beobachtung4 Studien
Cognitive function
Zu wenige bewertete Studien2 Studien
Safety profile
Zu wenige bewertete Studien2 Studien
Energy & fatigue
Zu wenige bewertete Studien1 Studie
Women's health
Zu wenige bewertete Studien1 Studie
Longevity & aging
Zu wenige bewertete Studien1 Studie
Aktives Forschungsgebiet
7 Studien in den letzten 5 Jahren · Neueste Meta-Analyse: 2026
199620112026
1Meta-Analyse2020
Kongkaew C, Meesomperm P, Scholfield CN, Chaiwiang N, Waranuch N · J Cosmet Sci (2020)
Luo W, Sun Y, Weng Y, Huang K, Gan Y. · Frontiers in endocrinology (2026)
Oxygen-based therapies, device-based therapies, placental products, growth factor/blood-derived therapies, and matrix/skin substitute products showed the most consistent potential benefits.
Nevertheless, heterogeneity, sparse networks, variable certainty of evidence, and limited direct comparisons preclude a definitive treatment hierarchy.
High-quality randomized trials with standardized outcome definitions and adequate follow-up are needed to clarify the optimal use of adjunctive therapies in DFU management.
Einfach gesagt: There were no clinically significant differences in time to lesion healing, erythema, or oozing/crusting between groups. On day 21, 100% of patients agreed that their lesions had improved.
Lynde CW, Andriessen A, Guenther L, Dayeh N, et al. · J Drugs Dermatol (2025)
RCT (n=60) after cryotherapy for actinic keratoses: a non-prescription balm with panthenol, madecassoside, and metal salts vs a topical antibiotic
Madecassoside-containing balm gave wound healing equivalent to the antibiotic, with 100% reporting improvement by day 21 and no related adverse events
Non-inferiority design and a multi-ingredient balm — supports soothing/healing, but not centella in isolation
Einfach gesagt: After 6 months of treatment, we observed a significant improvement of the clinical score for deep and superficial wrinkles, suppleness, firmness, roughness and skin hydration.
Haftek M, Mac-Mary S, Le Bitoux MA, Creidi P, et al. · Exp Dermatol (2008)
Randomized double-blind study (n=20) of topical 5% vitamin C + 0.1% madecassoside on photoaged skin over 6 months
Significant improvement in deep/superficial wrinkles, suppleness, firmness, roughness, and hydration, with histologic elastic-fibre remodeling
Madecassoside was co-formulated with vitamin C and n was small — its independent effect is not isolated
Einfach gesagt: Preclinical evidence further indicates attenuation of cellular senescence, improvement of mitochondrial function, enhanced collagen synthesis, and regulation of cytokine production. However, clinical translation remains limited due to insufficient randomized controlled trials.
Borowicz KK. · Nutrients (2026)
Review of centella triterpenes' antioxidant, anti-inflammatory, and regenerative activity (NF-κB, PI3K/Akt/mTOR, Nrf2/HO-1, TGF-β/Smad signaling)
Preclinical evidence indicates enhanced collagen synthesis and attenuated cellular senescence relevant to skin aging
Explicitly notes clinical translation is limited by insufficient RCTs and variable extract standardization
Einfach gesagt: Available topical modalities generally lack strong evidence from rigorous, well-designed, randomized controlled trials with ample numbers of subjects.
Korgavkar K, Wang F. · Br J Dermatol (2015)
Review identified centella as one of few topicals with any evidence for preventing/reducing striae, but the evidence is explicitly 'limited'
Topical modalities for striae generally lack strong evidence from rigorous, adequately-powered RCTs
Centella striae creams are typically combination products, so the centella-specific contribution is uncertain — counter-evidence on scar/striae claims
Einfach gesagt: Low dose of TECA did not exhibit toxicity and showed a protective effect against UVB irradiation in NDHFs.
An IS, An S, Kang SM, Choe TB, et al. · Int J Mol Med (2012)
In cultured human dermal fibroblasts, titrated centella extract (asiatic/madecassic acid, asiaticoside, madecassoside) protected against UVB damage at non-toxic doses
Altered microRNA profiles linked to cell proliferation and anti-apoptosis, suggesting a photoprotective mechanism
In-vitro only — establishes plausible mechanism, not a clinical effect