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Cin6.8
Cinnamon – Forschung
Überwiegend Mechanismus / Beobachtung
36 begutachtete Studien
Was die Evidenz sagt
Überwiegend Mechanismus / Beobachtung
Die meisten Studien zu Cinnamon sind mechanistisch oder beobachtend statt RCTs, die einen klinischen Effekt messen — betrachte die Ergebnisse als vorläufig.
Die meiste Evidenz stammt aus hochwertigen Meta-Analysen und randomisierten Studien, veröffentlicht 2011–2026 mit einer typischen Studiengröße von 77 Teilnehmenden.
Basierend auf 36 Studien · 17 Meta-Analysen · 7 RCTs · 1,134 Teilnehmende insgesamt
Konfidenz
Hohe Konfidenz
Was die Studien gefunden haben
1geholfen· 35 weitere ohne bewertete Effektdaten
Nach Outcome
Glucose & metabolicModerate Senkung des Nüchternblutzuckers und der Insulinresistenz, insbesondere bei Typ-2-Diabetes und Prädiabetes · 4-12 Wochen · Verbesserungen bei Glukose-, Lipid- und anthropometrischen Markern bei metabolischen Erkrankungen · 8-12 Wochen
Überwiegend Mechanismus / Beobachtung16 Studien
Cholesterol & lipidsGeringe Senkung von Gesamtcholesterin, Triglyceriden und Blutdruck · 8-12 Wochen
Überwiegend Mechanismus / Beobachtung6 Studien
Women's healthVerringerte Stärke von Menstruationsschmerzen bei primärer Dysmenorrhoe · 1-3 Zyklen
Überwiegend Mechanismus / Beobachtung3 Studien
Heart & blood pressureGeringe Senkung von Gesamtcholesterin, Triglyceriden und Blutdruck · 8-12 Wochen
Zu wenige bewertete Studien2 Studien
Anemia & hematology
Zu wenige bewertete Studien2 Studien
Safety profile
Zu wenige bewertete Studien2 Studien
Weight managementModerate Reduktion von BMI, Taillenumfang und Körperfett bei höheren Dosierungen · 8-12 Wochen
Zu wenige bewertete Studien2 Studien
Liver health
Zu wenige bewertete Studien2 Studien
6 weitere Outcomes mit weniger Studien nicht angezeigt.
Aktives Forschungsgebiet
27 Studien in den letzten 5 Jahren · Neueste Meta-Analyse: 2025
201120182026
1Fasting blood sugar reductionMeta-Analyse2024
Across 24 RCTs, cinnamon supplementation significantly reduced fasting blood sugar, HOMA-IR, and HbA1c versus control in type 2 diabetes.
Moridpour AH et al. · Phytotherapy research : PTR (2024)
Sehr groß Nutzen
← SchlechterKein EffektBesser →
Likely real
Significant reduction in fasting blood sugar (SMD −1.32; 95% CI −1.77 to −0.87; p<0.001)
Significant reduction in HbA1c (SMD −0.67; 95% CI −1.18 to −0.15; p=0.011)
By focusing on the cell membrane as an integrative signaling hub, this review reframes cinnamon as a membrane-active nutraceutical capable of restoring metabolic balance through coordinated modulation of ion channel GPCR networks.
We discuss how cinnamon influences calcium signaling, transient receptor potential (TRP) channels, and metabolite- and hormone-sensing GPCRs, thereby affecting insulin secretion, incretin release, appetite control, thermogenesis, and inflammatory tone.
A central highlight of this review is the crosstalk between ion channels and GPCRs in metabolic tissues, illustrating a systems-level mechanism through which cinnamon exerts pleiotropic metabolic benefits.
Translational implications are explored, including the potential of cinnamon to complement existing antidiabetic therapies and its relevance within precision nutrition frameworks.
Conclusions Only ginger and black cumin reported a significant improvement in glycated hemoglobin, and only cinnamon and ginger showed a significant decrease in insulin.
Garza MC, Pérez-Calahorra S, Rodrigo-Carbó C, Sánchez-Calavera MA, Jarauta E, Mateo-Gallego R, Gracia-Rubio I, Lamiquiz-Moneo I. · Nutrients (2024)
Our results showed that cinnamon, turmeric, ginger, black cumin, and saffron significantly improved the fasting glucose levels in T2DM subjects.
The most significant decreases in fasting glucose were achieved after supplementation with black cumin, followed by cinnamon and ginger, which achieved a decrease of between 27 and 17 mg/dL.
Conclusions Only ginger and black cumin reported a significant improvement in glycated hemoglobin, and only cinnamon and ginger showed a significant decrease in insulin.
It introduces a three-step framework, i.e., species selection, matrix matching, and authentication to guide evidence-based functional food development, while identifying species-authenticated bioavailability trials and food-based RCTs as research priorities.
Balkrishna A, Tripathi SK, Singh SK, Verma S, Arya V. · Food research international (Ottawa, Ont.) (2026)
Its bioactive constituents, principally cinnamaldehyde (55-85% of bark oil), Type-A procyanidins, and phenolic acids, have attracted increasing attention for their role in glycemic regulation.
Type-A procyanidins have been shown to exhibit approximately 20-fold insulin-mimetic potency in vitro.
Thermal processing above 150 °C reduces cinnamaldehyde; protein-polyphenol binding in dairy and lipid partitioning alter bioaccessibility; encapsulation can mitigate these losses.
This brief article highlights research on the functionality of spices, namely cinnamon and ginger, to influence microbial proliferation, the production of gut-derived metabolites and hormones, and prospective health outcomes.
Crowe-White KM, Senkus KE, DiNatale JC. · Nutrition reviews (2026)
A noteworthy strategy for harnessing the potential of this ecosystem is the consumption of prebiotics-non-digestible compounds promoting the growth of beneficial bacteria.
While dietary polyphenols are emerging as significant modulators of microbial proliferation and systemic therapeutic effects, the prebiotic functionality of spice polyphenols remains understudied.
It is, however, hypothesized that metabolism of spice polyphenols by intrinsic microflora in the colon may elicit downstream cardiometabolic effects resulting from the stimulated release of gut-derived metabolites, specifically short-chain fatty acids.
In conclusion, nanoencapsulation of essential oils and plant extracts is an effective natural strategy for improving oxidative stability in meat products.
Abedini A, Shokri S, Mirmoghtadaie L, Shojaee-Aliabadi S. · Food chemistry: X (2026)
PV reductions ranged from 20 to 70%, and shelf life was extended by 3-60 days with improved sensory acceptability.
Analysis of 62 studies showed that nanoemulsions, nanoliposomes, nanocapsules, and nanocoatings consistently reduced peroxide value (PV) and thiobarbituric acid reactive substances (TBARS).
For example, chili seed oil nanoemulsion lowered TBARS from 2.42 to 0.42 mg/kg; nanoencapsulated thyme oil (50-70 mg/kg) and cinnamon nanoemulsion effectively retarded oxidation.
Gou H, Zhong L, Wei Q, Fan Y. · Frontiers in nutrition (2025)
Additionally, cinnamon shows potential in modulating insulin resistance, antioxidant capacity, and blood pressure regulation.
Conclusion These results underscore the promising role of cinnamon as an adjunctive therapy for metabolic diseases.
Future research should focus on well-designed randomized controlled trials with extended follow-up periods to further confirm its efficacy and elucidate underlying mechanisms, thereby providing robust evidence for clinical and public health applications.
The review concludes with a discussion of the future research needed, including the need for clinical studies and potential risk associated with cinnamon intake.
Anderson M, Hrivnak W, Prak K, Stockert A. · Frontiers in nutrition (2025)
Nuclear factor erythroid related factor 2 (Nrf2) is also examined and has been indicated to affect cancer progression and potentially provide preventative measures; various cinnamon derivatives target Nrf2.
A cinnamaldehyde derivative has been implicated in a reduction of the mitogen-activated protein kinases (MAPKs), which are a group of kinases that regulate proliferation.
Additionally, cinnamon components have been tied to cancer prevention by positively affecting the gut microbiome and inhibiting inflammation.