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Cqu4.0
Cissus Quadrangularis – Forschung
Überwiegend Mechanismus / Beobachtung
17 begutachtete Studien
Was die Evidenz sagt
Überwiegend Mechanismus / Beobachtung
Die meisten Studien zu Cissus Quadrangularis sind mechanistisch oder beobachtend statt RCTs, die einen klinischen Effekt messen — betrachte die Ergebnisse als vorläufig.
Die meiste Evidenz stammt aus hochwertigen Meta-Analysen und randomisierten Studien, veröffentlicht 2006–2026 mit einer typischen Studiengröße von 354 Teilnehmenden.
Basierend auf 17 Studien · 2 Meta-Analysen · 11 RCTs · 602 Teilnehmende insgesamt
Konfidenz
Hohe Konfidenz
Nach Outcome
Weight managementProprietäre Cissus-Kombinationsprodukte reduzierten in Studien das Körpergewicht und verbesserten Lipide/Glukose gegenüber Placebo, die Datenlage für den Einzelwirkstoff ist jedoch schwächer · 6-8 weeks
Überwiegend Mechanismus / Beobachtung7 Studien
Bone healthKann die Frakturheilung unterstützen und Knochenumbaumarker verlangsamen; eine Metaanalyse zeigte einen Nutzen bei Frakturen, eine kontrollierte Studie fand jedoch keine Veränderung der Knochenmineraldichte · 6-24 weeks
Überwiegend Mechanismus / Beobachtung6 Studien
Safety profile
Zu wenige bewertete Studien1 Studie
Aktives Forschungsgebiet
8 Studien in den letzten 5 Jahren · Neueste Meta-Analyse: 2025
200620162026
1Meta-Analyse2017
Sawangjit R, Puttarak P, Saokaew S, Chaiyakunapruk N · Phytother Res (2017)
Jain A, Dixit J, Prakash D · J Int Acad Periodontol (2008)
12Übersicht2026
Einfach gesagt: However, the absence of standardized formulations, small sample sizes, short follow-ups, and lack of head‑to‑head comparisons with standard anti‑osteoporotic therapies currently available underscore the need for long-term, multicenter randomized controlled studies using bioavailable, well-characterized CQ preparations.
Manocchio N, Sorbino A, Devito A, Gallelli L, Romanello D, Rotunno S, Foti C, Migliore A. · Orthopedic research and reviews (2026)
In postmenopausal osteopenia, randomized trials show that 24‑week oral CQ stabilizes bone turnover markers and delays bone loss, albeit without short‑term gains in bone mineral density.
Published in Orthopedic research and reviews (2026)
Einfach gesagt: Conclusion It seems that plant-derived medicines have beneficial effects on bone and may manage osteoporosis by affecting different targets and pathways involved in osteoporosis; However, Future studies are needed to confirm the effectiveness and safety of these preparations.
Karimi SM, Bayat M, Rahimi R. · Journal of traditional and complementary medicine (2024)
It seems that multi-component herbal preparations were more effective than single-component ones; because of the synergistic effects of their constituents.
The investigated herbal medicines demonstrated their promising results in osteoporosis via targeting different pathways in bone metabolism, including balancing osteoblasts and osteoclasts, anti-inflammatory, immunomodulatory, antioxidant, and estrogen-like functions.
Conclusion It seems that plant-derived medicines have beneficial effects on bone and may manage osteoporosis by affecting different targets and pathways involved in osteoporosis; However, Future studies are needed to confirm the effectiveness and safety of these preparations.
Einfach gesagt: Clinical trial number Not applicable.
Na Takuathung M, Aisara J, Sawong S, Koonrungsesomboon N. · BMC complementary medicine and therapies (2025)
The summary effect measure was the standardized mean difference (SMD) with 95% confidence intervals (95% CI).
The analysis revealed that CQ intervention significantly elevated serum parathyroid hormone levels (SMD = 1.23; 95% CI = 0.79 to 1.67; p < 0.0001).
Conclusion The CQ intervention was significantly associated with increased serum parathyroid hormone levels, with no significant effects on other bone-related biomarkers.
Einfach gesagt: These findings indicate that both botanicals are promising natural agents for managing obesity through incretin-based mechanisms.
Youovop J, Takuissu G, Minoue R, Nwang F, Adegboyega M, Arrey C, Makamwe I, Oben J. · Medicina (Kaunas, Lithuania) (2025)
Results : Participants receiving DGE or CQE displayed notable elevations in circulating GLP-1 (+38.6 pg/mL and +42.2 pg/mL, respectively; p < 0.01) and significant reductions in DPP-4 activity (-15.3% and -17.8%; p < 0.01) compared with placebo.
Both extracts produced substantial improvements in body weight (-5.2% and -5.8%), body fat (-10.3% and -10.9%), energy intake (-16.2% and -17.5%), and satiety (+25.6% and +27.4%) ( p < 0.01).
Significant changes in fasting glucose and serum lipid levels were also observed ( p < 0.05).
Einfach gesagt: Cissus protected the microarchitecture of the long bones from ovariectomy-induced bone loss, likely via the BMP and Wnt signaling pathways.
Guerra JM, Hanes MA, Rasa C, Loganathan N, Innis-Whitehouse W, Gutierrez E, Nair S, Banu J · J Bone Miner Metab (2019)
Ovariectomized rats fed Cissus for 3 months retained trabecular bone in femur and tibia
Einfach gesagt: Cissus suppressed RANKL-induced osteoclastogenesis and preserved bone microarchitecture by shifting the host osteoimmune balance toward anti-osteoclastogenic immune cells.