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Clm5.5
Colostrum – Forschung
Hilft wahrscheinlich
41 begutachtete Studien
Was die Evidenz sagt
Hilft wahrscheinlich
Colostrum scheint in 3 von 3 Studien mit messbaren Effekten zu helfen — die Evidenz tendiert klar ins Positive.
Die meiste Evidenz stammt aus hochwertigen Meta-Analysen und randomisierten Studien, veröffentlicht 2014–2026 mit einer typischen Studiengröße von 116 Teilnehmenden.
Basierend auf 41 Studien · 3 Meta-Analysen · 7 RCTs · 14,833 Teilnehmende insgesamt
Konfidenz
Hohe Konfidenz
Was die Studien gefunden haben
3geholfen· 38 weitere ohne bewertete Effektdaten
Nach Outcome
Gastrointestinal & gut barrierImmunglobuline unterstützen die Integrität und Reparatur der Darmbarriere · 2-4 Wochen
Überwiegend Mechanismus / Beobachtung10 Studien
Immune support & infectionsVerbesserte mukosale Immunität · 2-4 Wochen
4Athletic performance in soccer playersMeta-AnalyseCited 6×2025
This study suggests that a range of dietary supplements, including caffeine, creatine, creatine + sodium bicarbonate, magnesium creatine chelate, carbohydrate + electrolyte, carbohydrate + protein, arginine, beta-alanine, bovine colostrum, Kaempferia parviflora, melatonin, and sodium pyruvate, can improve athletic performance in soccer players.
Luo H et al. · Journal of the International Society of Sports Nutrition (2025)
Kaempferia parviflora (SMD: 0.46, small) was associated with a significant effect on enhancing muscular strength.
Beta-alanine (SMD: 0.83, moderate), melatonin (SMD: 0.75, moderate), caffeine (SMD: 0.37, small), and creatine (SMD: 0.33, small) were associated with a significant effect on enhancing jump height.
Magnesium creatine chelate (SMD: -3.0, very large), melatonin (SMD: -1.9, large), creatine + sodium bicarbonate (SMD: -1.4, large), and arginine (SMD: -1.2, moderate) were associated with a significant effect on decreasing sprint time.
The present systematic review and meta-analysis provides evidence that bovine colostrum supplementation may be effective in preventing the incidence of URS days and episodes in adults engaged in exercise training.
Jones AW et al. · BMC Sports Science, Medicine and Rehabilitation (2016)
Over an 8-12 week follow-up period, bovine colostrum supplementation when compared to placebo significantly reduced the incidence rate of URS days (rate ratio 0.56, 95 % confidence intervals 0.43 to 0.72, P value < 0.001) and URS episodes (0.62, 0.40 to 0.99, P value = 0.04) by 44 and 38 % respectively.
Five trials (152 participants) met the inclusion criteria, all of which involved individuals involved in regular exercise training.
The present systematic review and meta-analysis provides evidence that bovine colostrum supplementation may be effective in preventing the incidence of URS days and episodes in adults engaged in exercise training.
BC supplementation may be highly beneficial in improving gut permeability in athletes.
Dziewiecka H et al. · Nutrients (2022)
BC supplementation may be highly beneficial in improving gut permeability in athletes.
However, well-designed, placebo-controlled, and randomized studies are needed to evaluate the long-term safety and efficacy and to determine the optimal dose schedules of BC supplementation in high-performance athletes.
7Multiple outcomes including upper respiratory illness prevention, immune system modulation, intestinal permeability reductionSystematische ÜbersichtCited 20×2021
Further studies are mandatory to better understand all factors influencing its activity.
Guberti M et al. · Nutrients (2021)
Bovine colostrum topical application was shown effective on vaginal dryness related symptoms limitation.
Its use as food supplement showed interesting effects preventing upper respiratory illness in sportsmen, modulating immune system response and reducing intestinal permeability in healthy and sick subjects.
Conflicting results were provided in pediatric population and little evidence is available on its use with older adults.
8Exercise-associated gut damage and permeability markersSystematische ÜbersichtCited 16×2022
However, research is needed to clarify if this will contribute to improved athlete gastrointestinal and performance outcomes.
Chantler S et al. · PloS one (2022)
Single strain probiotic strains showed some positive findings, but the results are likely strain, dosage and duration specific.
Bovine colostrum, glutamine, carbohydrate supplementation and maintaining euhydration may reduce exercise-associated endothelial damage and improve gut permeability.
In spite of a large heterogeneity across the selected studies, appropriate inclusion of different nutrition strategies could mitigate the initial phases of gastrointestinal cell disturbances in athletes associated with exercise.
9Clinical benefits of bovine colostrum supplementationSystematische ÜbersichtCited 92×2014
Animal models may help researchers to better understand the mechanisms of bovine colostrum supplementation, the dosage regimens required to obtain clinical benefits, and the optimal methods for testing these effects in humans.
Rathe M et al. · Nutrition reviews (2014)
Many studies used surrogate markers to study the effects of bovine colostrum.
Studies suggesting clinical benefits of colostrum supplementation were generally of poor methodological quality, and results could not be confirmed by other investigators.
Bovine colostrum may provide gastrointestinal and immunological benefits, but further studies are required before recommendations can be made for clinical application.
10Beobachtungsstudien=7,251 · very large study2026
This highlights the need for continued research to develop more effective interventions that can support piglet survival and performance.
Luise D, Polimeni B, Trevisi P. · Journal of animal science (2026)
Milk replacers closely approximate the composition of porcine colostrum and can improve piglet growth, including low-birth-weight piglets, while also exerting positive effects on intestinal structure, immune system, and intestinal microbiota.
Additional benefits may be obtained through the supplementation of other bioactive compounds (amino acids, probiotics), although the optimal dosage and timing of administration remain to be determined.
To date, no substitute has proven fully capable of replicating the complex and unique functional properties of porcine colostrum.
11Body fat content and blood lipid profileSystematische Übersicht2026
Assessments should include blood metabolic biomarkers, body composition measured by dual-energy X-ray absorptiometry, gut microbiome composition, and fecal short-chain fatty acids to determine whether any observed benefits are attributable to COL alone or to its combination with dietary intervention.
Goluch Z et al. · Nutrients (2026)
Kaum spürbar Nutzen
← SchlechterKein EffektBesser →
Borderline
One study in older adults reported that COL supplementation at 60 g/day for 8 weeks significantly reduced body fat percentage by 0.4% (p < 0.05).
Another study found that COL supplementation at 10 g/day combined with plant proteins for 12 weeks significantly attenuated the increase in leg tissue fat percentage compared with placebo (PLA) (0.48 ± 1.29% vs. 1.12 ± 1.27%, respectively; p < 0.05).
In individuals with type 2 diabetes, COL supplementation at 10 g/day for 4 weeks significantly reduced total cholesterol (TC) and triglyceride levels in both men and women, by 8.27% vs. 7.62% and 11.96% vs. 21.46%, respectively.
12Growth factors concentration and benefitsSystematische Übersicht2024
This review article examines the growth factors concentration in bovine colostrum, their benefits, clinical studies, and molecular mechanisms.
Yalçıntaş YM et al. · Nutrients (2024)
Growth factors contribute to wound healing, muscle and bone development, and supporting growth in children.
Additionally, the molecular mechanisms have been explored, highlighting the growth factors roles in cell proliferation, tissue regeneration, and the regulation of immune responses.
These findings are crucial for understanding the potential health effects of bovine colostrum, ensuring its safe use, and forming a basis for future clinical applications.
13distribution, structure, and biological function of dietary sialic acidsSystematische Übersicht2024
In this review, we summarize the distribution, structure, and biological function of particular Sia-rich diets, including human milk, bovine milk, red meat, and egg.
Zhang T et al. · Critical reviews in food science and nutrition (2024)
Among them, breast milk, especially colostrum, contains a high concentration of sialylated oligosaccharides.
Numerous reviews have concentrated on the physiological function of Sia as a cellular component of the body and its relationship with the occurrence of diseases.
However, the consumption of Sias through dietary sources exerts significant influence on human health, possibly by modulating the gut microbiota's composition and metabolism.
14Antiviral effects on human papillomavirusSystematische Übersicht2024
Here, we overview the current knowledge of lactoferrin and its effects on HPV and other viral infections.
Kaplan M et al. · Nutrients (2024)
One of the viruses that lactoferrin exerts significant antiviral effects on is the human papillomavirus (HPV), which is the most prevalent transmitted infection affecting a myriad of people around the world.
Along with HPV, lactoferrin also can inhibit a range of viruses including coronaviruses and hepatitis viruses in the same manner.
Here, we overview the current knowledge of lactoferrin and its effects on HPV and other viral infections.
This review hopes to use the above evidence to make people understand the health role of bovine colostrum as having a human immunomodulatory effect, and at the same time, when seeing the potential value of bovine colostrum in the future, the limitations of its application should also be deeply re-explored, such as lactose intolerance, allergies, etc., to provide effective solutions for the wide application of bovine colostrum.
Duan H et al. · Nutrients (2024)
In addition, the influencing factors affecting the quality of bovine colostrum (immunoglobulin) were reviewed, and it was found that individual differences, environmental factors, and processing methods had a great impact on the quality of BC.
More importantly, the immunomodulatory effects of bovine colostrum in people of all ages were reviewed in detail (with an emphasis on preterm infants and immunocompromised children in neonates) as evidence to support the immunity effects of colostrum in people of all ages.
This review provides a synopsis of the bioactive components in bovine colostrum, the processing techniques used to produce high-value colostrum-based products, and recent studies utilizing bovine colostrum for veterinary and human health.
Linehan K et al. · Annual review of food science and technology (2023)
Bovine colostrum harbors a diverse array of bioactive components suitable for the development of functional foods, nutraceuticals, and pharmaceuticals with veterinary and human health applications.
Bovine colostrum has a strong safety profile with applications across all age groups for health promotion and the amelioration of a variety of disease states.
Increased worldwide milk production and novel processing technologies have resulted in substantial growth of the market for colostrum-based products.
While additional verification of the safety and efficacy of these supplements is still necessary, current evidence suggests that these supplements have potential applications for health promotion and disease prevention among athletes and more diverse populations.
Suzuki K · Nutrients (2021)
Second, the effects of various supplements on immune function are discussed, including antioxidant defense modulators (vitamin C, sulforaphane, taheebo), and inflammation reducers (colostrum and hyperimmunized milk).
Third, how 3-hydroxy-3-methyl butyrate monohydrate (HMB) may offset muscle damage is reviewed.
Fourth and finally, the relationship between exercise, nutrition and COVID-19 infection is briefly mentioned.
18Gastrointestinal health and mucosal healingSystematische Übersicht2021
Given the robust scientific rationale for using bovine colostrum as a promoter of mucosal healing, further work is needed to define its role in therapy.
Chandwe K et al. · Nutrients (2021)
These disorders include enteropathy due to non-steroidal anti-inflammatory drugs (NSAIDs), inflammatory bowel disease (IBD), necrotizing enterocolitis, infectious diarrhea, intestinal failure, and damage due to cancer therapy.
In animal models, bovine colostrum benefits NSAID enteropathy, IBD, and intestinal failure.
In human trials, there is substantial evidence of efficacy of bovine colostrum in inflammatory bowel disease and in infectious diarrhea.
19Immune effects and disease preventionSystematische Übersicht2021
The review focuses predominantly on human data.
Ghosh S et al. · Nutrients (2021)
In this review, we predominantly focused on evidence from human studies on benefits in health and disease.
This review highlights that clear evidence of the prevention of infectious diseases in pre-term infants such as necrotizing enterocolitis, neonatal sepsis or prevention of cancer metastasis is lacking.
This is clearly an area where translational science has to be strengthened, taking the considerable evidence from numerous ex vivo studies on cells and tissues and from animal interventions.
Nevertheless, dose-response studies would be valuable for determining the minimum efficacious dose, although this is complicated by variability in bioactivity between products, making any dose-response findings applicable only to the specific products used in such studies.
Davison G · Nutrients (2021)
There is stronger evidence for benefit on gut permeability and damage markers and on immune function and illness risk, especially during periods of intensified training.
The balance of available evidence for gut permeability and illness risk is positive, but further research is required to fully determine all mechanisms responsible for these effects.
Early suggestions that supplementation with bovine colostrum products could increase systemic IGF-1 levels are not supported by the balance of available evidence examining a range of doses over both short- and long-term periods.