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Dha5.5
DHEA – Forschung
Hilft vermutlich
29 begutachtete Studien
Was die Evidenz sagt
Hilft vermutlich
DHEA half in etwa der Hälfte (4/8) der Studien, die einen Effekt gemessen haben — vielversprechend, aber nicht einhellig.
Die meiste Evidenz stammt aus hochwertigen Meta-Analysen und randomisierten Studien, veröffentlicht 1999–2026 mit einer typischen Studiengröße von 1,188 Teilnehmenden.
Basierend auf 29 Studien · 16 Meta-Analysen · 1 RCT · 21,770 Teilnehmende insgesamt
Konfidenz
Hohe Konfidenz
Was die Studien gefunden haben
4geholfen2unklar2nicht geholfen· 21 weitere ohne bewertete Effektdaten
Nach Outcome
Women's healthKann bei der Bewältigung von Wechseljahresbeschwerden wie Hitzewallungen und Stimmungsschwankungen helfen · 4-8 weeks · Unterstützt einen gesunden Östrogenstoffwechsel und das hormonelle Gleichgewicht · 4-8 weeks
Begrenzte Belege9 Studien
Fertility & reproductiveKann die reproduktive Gesundheit und Fertilitätsmarker unterstützen · 4-12 weeks
Überwiegend Mechanismus / Beobachtung7 Studien
Therapeutic & clinical
Überwiegend Mechanismus / Beobachtung5 Studien
Men's vitalityDirekte Vorstufe der Testosteron- und Östrogensynthese · 4-8 weeks
Gemischte Evidenz4 Studien
Depression & moodWiederhergestellte DHEA-Spiegel und nachgeschaltete Hormone · 4-12 weeks
Überwiegend Mechanismus / Beobachtung3 Studien
Bone healthUnterstützt die Knochenmineraldichte und die Skelettfestigkeit · 8-12 weeks
Überwiegend Mechanismus / Beobachtung3 Studien
Anxiety & stress
Überwiegend Mechanismus / Beobachtung3 Studien
Safety profile
Überwiegend Mechanismus / Beobachtung3 Studien
Glucose & metabolic
Zu wenige bewertete Studien2 Studien
Cognitive function
Zu wenige bewertete Studien1 Studie
Cholesterol & lipids
Zu wenige bewertete Studien1 Studie
In Zahlen
Aus 21 Studien mit messbaren Effekten gezogen
Wahrscheinlich echte Effekte
80%
über Studien hinweg
Untersuchte Personen
22k
typische Studie: 1188 Personen
Stärkste Designs
17
16 gepoolt, 1 randomisiert
Zeigte Nutzen
50%
4/8 Studien
Wie lange Studien liefen
1–3 Monate
1
Untersuchte Populationen
Women with diminished ovarian reserve2
Poor ovarian response patients undergoing IVF-ET1
Patients with diminished ovarian reserve/poor ovarian response1
Poor responders undergoing IVF1
Aktives Forschungsgebiet
19 Studien in den letzten 5 Jahren · Neueste Meta-Analyse: 2025
199920122026
1Meta-Analysen=1,433 · large study2024
Future studies should include data collection on adverse events and multiple pregnancy.
Naik S, Lepine S, Nagels HE, Siristatidis CS, Kroon B, McDowell S. · The Cochrane database of systematic reviews (2024)
Pre-treatment with DHEA versus placebo/no treatment: DHEA likely results in little to no difference in live birth/ongoing pregnancy rates (OR 1.30, 95% confidence interval (CI) 0.95 to 1.76; I² = 16%, 9 RCTs, N = 1433, moderate certainty evidence).
This suggests that in women with a 12% chance of live birth/ongoing pregnancy with placebo or no treatment, the live birth/ongoing pregnancy rate in women using DHEA will be between 12% and 20%.
DHEA likely does not decrease miscarriage rates (OR 0.85, 95% CI 0.53 to 1.37; I² = 0%, 10 RCTs, N =1601, moderate certainty evidence).
2Clinical pregnancy rateMeta-AnalyseCited 11×n=2,323 · very large study2023
Compared with COS regimen, the adjuvant use of CoQ10, DHEA and GH before IVF may have a better clinical effect on the pregnancy outcome of POR patients.
Zhu F et al. · Reproductive biology and endocrinology : RB&E (2023)
Sehr groß Schaden
← SchlechterKein EffektBesser →
Compared with the control group, CoQ10 (OR 2.22, 95% CI: 1.05 to 4.71) and DHEA (OR 1.92, 95% CI: 1.16 to 3.16) had obvious advantages in improving the clinical pregnancy rate.
CoQ10 was the best in improving the live birth rate (OR 2.36, 95% CI: 1.07 to 5.38).
DHEA increased the embryo implantation rate (OR 2.80, 95%CI: 1.41 to 5.57) and the high-quality embryo rate (OR 2.01, 95% CI: 1.07 to 3.78) and number of oocytes retrieved (WMD 1.63, 95% CI: 0.34 to 2.92) showed a greater advantage, with GH in second place.
6DHEA-S levelsMeta-AnalyseCited 51×n=1,742 · large study2018
Effect size (ES) estimates were calculated as Hedges' g.
Misiak B et al. · Psychoneuroendocrinology (2018)
Groß Nutzen
← SchlechterKein EffektBesser →
Likely real
Effect size (ES) estimates were calculated as Hedges' g.
Main analysis revealed elevated DHEA-S levels in the whole group of patients (ES = 0.75, 95%CI: 0.23-1.28, p = 0.005).
In subgroup analyses, patients with first-episode psychosis (FEP) had significantly higher levels of free testosterone (ES = 1.21, 95%CI: 0.30-2.12, p = 0.009) and DHEA-S (ES = 1.19, 95%CI: 0.66-1.71, p < 0.001).
7Sexual symptomsMeta-AnalyseCited 70×n=1,188 · large study2014
Evidence warranting low confidence suggests that DHEA administration does not significantly impact sexual symptoms or selected metabolic markers in postmenopausal women with normal adrenal function.
Elraiyah T et al. · The Journal of clinical endocrinology and metabolism (2014)
Kein klarer Effekt
← SchlechterKein EffektBesser →
Borderline
DHEA use was not associated with significant improvement in libido or sexual function (standardized mean difference, 0.35; 95% confidence interval, -0.02 to 0.73; P value = .06; I(2) = 62%).
Evidence warranting low confidence suggests that DHEA administration does not significantly impact sexual symptoms or selected metabolic markers in postmenopausal women with normal adrenal function.
8Live birth rateMeta-AnalyseCited 30×n=368 · medium study2025
Specific interventions such as testosterone seem to correlate with a better live birth rate in women with DOR; these findings should be further explored in randomized trials.
Conforti A et al. · Fertility and sterility (2025)
Sehr groß Schaden
← SchlechterKein EffektBesser →
Testosterone supplementation is associated with higher live birth rates compared with nonsupplemented women among all interventions evaluated (odds ratio: 2.19, 95% confidence interval [CI]: 1.11-4.32, four studies, 368 patients).
Lower number of oocytes retrieved is achieved in women undergoing low dose gonadotropin regimen vs high dose (WMD: -1.57, 95% CI: -2.12 to -1.17; 2 studies, n = 905 patients), The other interventions did not produce significant improvements.
Specific interventions such as testosterone seem to correlate with a better live birth rate in women with DOR; these findings should be further explored in randomized trials.
9Depressive symptomsMeta-AnalyseCited 8×n=742 · large study2020
However, these results should be viewed with caution, since the quality of evidence for this outcome was considered very low according to the GRADE criteria.
Peixoto C et al. · Journal of neuroscience research (2020)
No hormonal changes that indicated any risk to the participants' health were seen.
Side effects observed were uncommon, mild, and transient, but commonly related to androgyny.
In conclusion, DHEA was associated with a beneficial effect on depressive symptoms compared to placebo.
13Systematische ÜbersichtCited 11×n=55 · small study2022
We identified literature that lacks coherence in terms of the proposed treatments and selected outcome measures.
Sarmento ACA et al. · Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia (2022)
We identified literature that lacks coherence in terms of the proposed treatments and selected outcome measures.
The present review is registered with the International Prospective Register of Systematic Reviews (PROSPERO; CRD42018100488).
15Serum estradiol levels with hormonal treatmentsMeta-AnalyseCited 12×n=17 · very small study2023
We found that, among patients treated with the estriol and estradiol preparations, there was an average increase of 7.67 pg/mL (SMD 7.67 pg/mL; 95% CI -1.00, 16.35; p < .001).
Comini ACM et al. · Clinical breast cancer (2023)
Kein klarer Effekt
← SchlechterKein EffektBesser →
Likely real
We found that, among patients treated with the estriol and estradiol preparations, there was an average increase of 7.67 pg/mL (SMD 7.67 pg/mL; 95% CI -1.00, 16.35; p < .001).
In conclusion, among treatments available for BC survivors, low-dose vaginal estrogen showed the smallest changes in serum estradiol levels and had the most evidence, but safety remains unclear, especially for patients on aromatase inhibitors.
Alternative treatments such as ospemifene need more data supporting safety and efficacy.
Overall, supplementation with DHEA did not change circulating values of TC, LDL-C and TG, whereas it may decrease HDL-C levels.
Qin Y et al. · Nutrition, metabolism, and cardiovascular diseases : NMCD (2020)
Spürbar Nutzen
← SchlechterKein EffektBesser →
In addition, a significant reduction in HDL-C values was observed in studies comprising women (WMD: -5.1 mg/dl, 95% CI: -7.2 to -3) but not in males (WMD: 0.13 mg/dl, 95% CI: -1.4 to 1.7).
Overall, supplementation with DHEA did not change circulating values of TC, LDL-C and TG, whereas it may decrease HDL-C levels.
Further long-term RCTs are required to investigate the effects of DHEA particularly on major adverse cardiac events.
This systematic review evaluated the association between FPG and DHEA, revealing that the administration of DHEA reduces FPG levels.
Wang X et al. · Complementary therapies in medicine (2020)
Spürbar Nutzen
← SchlechterKein EffektBesser →
Likely real
Overall results demonstrated that FPG was significantly altered after DHEA consumption (WMD: -2.185 mg/dl, P = 0.029).
DHEA administration did not result in any significant changes in IN (WMD: 0.057 μU/mL, P = 0.067), and the HOMA - IR index (WMD: 0.174, P = 0.060).
In the subgroup analyses, FPG significantly decreased in the subgroup who received DHEA supplementation in dosages of ≤50 mg/day (WMD: -2.29 mg/dl), when the treatment duration was <12 weeks (WMD: -5.25 mg/dl), and in subjects aged ≥60 years (WMD: -2.94 mg/dl).
20Fertility outcomes in diminished ovarian reserveMeta-Analysen=2,773 · very large study2025
Registration number CRD42024580831.
Li X, Zhao Q, Lin G, Xu L. · Annals of medicine (2025)
Oral nutritional supplements for more than 2 months have a better effect on lowering FSH levels, raising AMH levels, and oocyte numbers ( p < 0.05).
There was a remarkable correlation ( p < 0.05) between the use of both nutritional supplements and the decrease of FSH, as well as the increase of AMH, AFC, and oocytes retrieved.
We used sensitivity analysis to conclude that our summary results are robust.