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Epo4.5
Evening Primrose Oil – Forschung
Hilft wahrscheinlich
85 begutachtete Studien
Was die Evidenz sagt
Hilft wahrscheinlich
Evening Primrose Oil scheint in 4 von 5 Studien mit messbaren Effekten zu helfen — die Evidenz tendiert klar ins Positive.
Die meiste Evidenz stammt aus hochwertigen Meta-Analysen und randomisierten Studien, veröffentlicht 1981–2026 mit einer typischen Studiengröße von 84 Teilnehmenden.
Basierend auf 85 Studien · 15 Meta-Analysen · 50 RCTs · 9,950 Teilnehmende insgesamt
Konfidenz
Hohe Konfidenz
Was die Studien gefunden haben
4geholfen1unklar· 80 weitere ohne bewertete Effektdaten
Nach Outcome
Women's healthNicht belegt — systematische Übersichtsarbeiten finden EPO bei PMS nicht anders wirksam als Placebo · 1-3 cycles · Keine kontrollierte Evidenz für Effekte auf den Östrogenstoffwechsel oder die Hormonspiegel · 4-8 weeks · Für EPO allein nicht belegt; die einzige Wechseljahresstudie verwendete eine Mischung aus vier Kräutern · 4-8 weeks
Überwiegend Mechanismus / Beobachtung27 Studien
Skin healthGLA kann die Hautbarriere/Trockenheit unterstützen; die Evidenz für Ekzeme ist schwach · 12-16 weeks · Cochrane fand orales EPO bei Ekzemen unwirksam; die Evidenz bei Akne ist schwach und nur adjuvant · 8-12 weeks
Überwiegend Mechanismus / Beobachtung19 Studien
Therapeutic & clinical
Überwiegend Mechanismus / Beobachtung18 Studien
InflammationGLA linderte Symptome der diabetischen Neuropathie; die breitere entzündungshemmende Datenlage ist heterogen · 8-12 weeks
Überwiegend Mechanismus / Beobachtung7 Studien
Joint pain & arthritis
Überwiegend Mechanismus / Beobachtung4 Studien
Cholesterol & lipids
Überwiegend Mechanismus / Beobachtung4 Studien
Heart & blood pressure
Überwiegend Mechanismus / Beobachtung3 Studien
Glucose & metabolic
Zu wenige bewertete Studien2 Studien
Immune support
Zu wenige bewertete Studien1 Studie
Cognitive function
Zu wenige bewertete Studien1 Studie
Safety profile
Zu wenige bewertete Studien1 Studie
In Zahlen
Aus 11 Studien mit messbaren Effekten gezogen
Wahrscheinlich echte Effekte
100%
über Studien hinweg
Untersuchte Personen
9,950
typische Studie: 84 Personen
Stärkste Designs
65
15 gepoolt, 50 randomisiert
Zeigte Nutzen
80%
4/5 Studien
Untersuchte Populationen
Patients with acne1
Patients with inflammatory diseases1
Adults with diabetic peripheral neuropathy1
Women with mastalgia1
Stetige Forschung
25 Studien in den letzten 5 Jahren · Neueste Meta-Analyse: 2025
198120032026
1Meta-AnalyseCited 61×n=1,596 · large study2013
With regard to the risk of bias, the majority of studies were of low risk of bias; we judged 67% of the included studies as having low risk of bias for random sequence generation; 44%, for allocation concealment; 59%, for blinding; and 37%, for other biases.
Bamford JT et al. · The Cochrane database of systematic reviews (2013)
With regard to the risk of bias, the majority of studies were of low risk of bias; we judged 67% of the included studies as having low risk of bias for random sequence generation; 44%, for allocation concealment; 59%, for blinding; and 37%, for other biases.
Oral intake of EPO at a dose of ≤4 g/day significantly reduces serum TG levels and significantly increases HDL levels in hyperlipidemic subjects.
Khorshidi M et al. · Phytotherapy Research (2020)
EPO supplementation had no significant effect on TC, TG, LDL, and HDL.
However, in subgroup analysis, a significant reduction in TG at a dose of ≤4 g/day (weighted mean difference [WMD] = -37.28 mg/dl; 95% CI: -73.53 to -1.03, p = .044) and a significant increase in HDL in hyperlipidemic subjects (WMD = 5.468 mg/dl; 95% CI: 1.323 to 9.614, p = .010) was found.
A total of 926 articles were identified through database searching, of which, six RCTs were included in the meta-analysis.
Allergy published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd.
Vassilopoulou E et al. · Allergy (2024)
A meta-analysis of 20 RCTs assessing probiotics, alone or combined with prebiotics, revealed a significant reduction in SCORAD scores, suggesting a consistent trend in alleviating AD symptoms in children without food allergies.
The review encompassed 27 RCTs examining prebiotics, Vitamin D, evening primrose oil, and substituting cow's milk formula with partially hydrolyzed whey milk formula.
Nonetheless, evidence for other dietary interventions remains limited, underscoring the necessity for well-designed intervention studies targeting multiple factors to understand etiological interactions and propose reliable manipulation strategies.
Some evidence regarding the potential benefits of EPO in inflammatory disorders were reported however caution is due to the limitations of the current survey.
Sharifi M et al. · BMC complementary medicine and therapies (2024)
In rheumatoid arthritis, mixed results were observed, with some studies reporting significant improvements in symptoms while others found no significant impact.
Some evidence regarding the potential benefits of EPO in inflammatory disorders were reported however caution is due to the limitations of the current survey.
Overall, contemporary literature is highly heterogeneous and fails to provide strong recommendations regarding the efficacy of EPO on inflammatory disorders.
15Systematische ÜbersichtCited 40×n=400 · medium study2011
On the contrary, neither evening primrose oil nor St. John's Wort show an effect different than placebo.
Dante G, Facchinetti F · Journal of Psychosomatic Obstetrics & Gynecology (2011)
On the contrary, neither evening primrose oil nor St. John's Wort show an effect different than placebo.
Vitex agnus castus was the more investigated remedy and it was reported to consistently ameliorate PMS better than placebo.
None of the herbs was associated with major health risks, although the reduced number of tested patients does not allow definitive conclusions on safety.
16Total Symptom Score improvement in diabetic neuropathyMeta-AnalyseCited 6×n=11 · very small study2024
ALA and GLA appear to be safe and efficacious biofactors for improvement of DN symptoms.
Prado MB Jr et al. · Canadian journal of diabetes (2024)
Sehr groß Nutzen
← SchlechterKein EffektBesser →
Likely real
Eight of the 11 articles (73%) reported significant benefit of ALA vs placebo.
In the meta-analysis, the Total Symptom Score (TSS) for ALA 600 mg/day (ALA600) was 1.05 points lower (standard mean difference [SMD] -1.05, 95% confidence interval [CI] -2.07 to -0.04, p=0.04, I2=98.18%) compared with control at the end of the study.
In the network meta-analysis, ALA600 (SMD -1.68, 95% CI -2.8 to -0.6) and GLA (SMD -2.39, 95% CI -4.3 to -0.5) had significantly lower TSSs compared with placebo.
In this systematic review we present information relating to the effectiveness and safety of the following interventions: antibiotics, bromocriptine, combined oral contraceptive pill, danazol, diuretics, evening primrose oil, gestrinone, gonadorelin analogues, hormone replacement therapy (HRT), lisuride, low-fat diet, progestogens, pyridoxine, tamoxifen, tibolone, topical or oral non-steroidal anti-inflammatory drugs (NSAIDs), toremifene, and vitamin E.
In this systematic review we present information relating to the effectiveness and safety of the following interventions: anticonvulsants, antihypertensive drugs, antioxidants, antiplatelet drugs, atenolol, bed rest, hospital admission, or day care, calcium supplementation, choice of analgesia during labour, early delivery (interventionist care), evening primrose oil, fish oil, glyceryl trinitrate, magnesium supplementation, plasma volume expansion, and salt restriction.
20Atopic dermatitis severityMeta-Analysen=3,763 · very large study2025
Nevertheless, larger, methodologically rigorous studies are essential to establish evidence for herbal remedies in atopic dermatitis treatment.
Anheyer M, Cramer H, Ostermann T, Anheyer D. · Dermatitis : contact, atopic, occupational, drug (2025)
Kein klarer Effekt
← SchlechterKein EffektBesser →
A meta-analysis on systemic used EPO, involving 13 RCTs, found no significant difference in atopic dermatitis severity compared with placebo (SMD: 0.14; 95% CI [-0.45; 0.73], 13 RCTs).
In conclusion, this review provides a nuanced perspective on herbal substance efficacy for atopic dermatitis.
While the EPO meta-analysis failed to show a discernible benefit beyond placebo, individual herbal preparations showed promising results in RCTs included in this review.