Feverfew – Forschung

Tanacetum parthenium and Salix alba (Mig-RL) combination in migraine prophylaxis: a prospective, open-label study.

Shrivastava R, Pechadre JC, John GW · Clin Drug Investig (2006)

The efficacy and safety of feverfew (Tanacetum parthenium L.): an update of a systematic review.

Ernst E, Pittler MH · Public Health Nutr (2000)

Feverfew for migraine prophylaxis: a systematic review.

Saranitzky E, White CM, Baker EL, Baker WL, Coleman CI · J Diet Suppl (2009)

Efficacy and safety of 6.25 mg t.i.d. feverfew CO2-extract (MIG-99) in migraine prevention--a randomized, double-blind, multicentre, placebo-controlled study.

Diener HC, Pfaffenrath V, Schnitker J, Friede M, Henneicke-von Zepelin HH · Cephalalgia (2005)

The combined effect of acupuncture and Tanacetum parthenium on quality of life in women with headache: randomised study.

Ferro EC, Biagini AP, da Silva ÍE, Silva ML, Silva JR · Acupunct Med (2012)

A double-blind placebo-controlled pilot study of sublingual feverfew and ginger (LipiGesic™ M) in the treatment of migraine.

Cady RK, Goldstein J, Nett R, Mitchell R, Beach ME, Browning R · Headache (2011)

The efficacy and safety of Tanacetum parthenium (feverfew) in migraine prophylaxis--a double-blind, multicentre, randomized placebo-controlled dose-response study.

Pfaffenrath V, Diener HC, Fischer M, Friede M, Henneicke-von Zepelin HH · Cephalalgia (2002)

A Critical Approach to Evaluating Clinical Efficacy, Adverse Events and Drug Interactions of Herbal Remedies.

Einfach gesagt: Systematic reviews/meta-analyses suggest preliminary or satisfactory clinical evidence for... feverfew (Tanacetum partenium) for migraine prevention... However, firm conclusions of efficacy cannot be generally drawn.

Izzo AA et al. · Phytotherapy research : PTR (2016)

Migraine Headache Prophylaxis

Einfach gesagt: Alternative agents, including feverfew, magnesium, and melatonin, have shown effectiveness and are generally well tolerated.

Moreland P, Gaffney B, Lanham JS. · American family physician (2025)

Exploring the Phytochemistry, Signaling Pathways, and Mechanisms of Action of Tanacetum parthenium (L.) Sch.Bip.: A Comprehensive Literature Review

Einfach gesagt: Additionally, the safety, toxicity, and potential adverse effects of feverfew are comprehensively evaluated, with an overarching goal of providing valuable insights into the plant's potential for targeted and effective treatments.

Kashkooe A, Jalali A, Zarshenas MM, Hamedi A. · Biomedicines (2024)

Systematic review and meta-analysis of Tanacetum parthenium: evaluating its efficacy in migraine relief

Einfach gesagt: Feverfew may offer modest benefits in migraine prevention, warranting further high-quality, large-scale RCTs with standardised protocols.

Nelaturi V, Viswanatha GL, Shenoy RR, Khanna S, Krishnadas N. · Natural product research (2025)

Randomised double-blind placebo-controlled trial of feverfew in migraine prevention.

Einfach gesagt: A landmark randomized, placebo-controlled trial found feverfew reduced the frequency and severity of migraine.

Murphy JJ et al. · Lancet (London, England) (1988)

Feverfew for preventing migraine.

Einfach gesagt: One larger rigorous study reporting 0.6 fewer attacks per month adds some positive evidence, but this is low quality evidence needing confirmation in larger rigorous trials.

Wider B et al. · The Cochrane database of systematic reviews (2015)

Feverfew as a preventive treatment for migraine: a systematic review.

Einfach gesagt: An early systematic review found feverfew more effective than placebo in most, but not all, trials.

Vogler BK et al. · Cephalalgia : an international journal of headache (1998)

Efficacy of feverfew as prophylactic treatment of migraine.

Einfach gesagt: An early controlled trial reported fewer migraines with feverfew.

Johnson ES et al. · British medical journal (Clinical research ed.) (1985)

Effects of nonprescription therapies on vestibular migraine: a questionnaire-based observational study

Einfach gesagt: Conclusions The results provide preliminary evidence that VM symptom frequency and severity can be reduced by using nonprescription therapies.

Hannigan IP, Rosengren SM, Di Tanna GL, Watson SRD, Welgampola MS. · Internal medicine journal (2024)

A combination of riboflavin, magnesium, and feverfew for migraine prophylaxis: a randomized trial.

Einfach gesagt: A combination of riboflavin, magnesium, and feverfew was studied for migraine prophylaxis.

Maizels M et al. · Headache (2004)

Anti-inflammatory activity of parthenolide-depleted Feverfew (Tanacetum parthenium).

Einfach gesagt: our results indicate that PD-Feverfew extracts have potent anti-inflammatory activity suggesting that this botanical would be efficacious in relieving inflammation without inducing immune sensitization.

Sur R et al. · Inflammopharmacology (2009)

Phase I dose escalation trial of feverfew with standardized doses of parthenolide in patients with cancer.

Einfach gesagt: A phase I dose-escalation study established tolerability of standardized parthenolide doses of feverfew.

Curry EA 3rd et al. · Investigational new drugs (2004)