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Gly6.5
Glycine – Forschung
Hilft wahrscheinlich
27 begutachtete Studien
Was die Evidenz sagt
Hilft wahrscheinlich
Glycine scheint in 6 von 6 Studien mit messbaren Effekten zu helfen — die Evidenz tendiert klar ins Positive.
Die meiste Evidenz stammt aus hochwertigen Meta-Analysen und randomisierten Studien, veröffentlicht 2005–2026 mit einer typischen Studiengröße von 20 Teilnehmenden.
Basierend auf 27 Studien · 5 Meta-Analysen · 15 RCTs · 1,610 Teilnehmende insgesamt
Konfidenz
Hohe Konfidenz
Was die Studien gefunden haben
6geholfen· 21 weitere ohne bewertete Effektdaten
Nach Outcome
Therapeutic & clinical
Hilft wahrscheinlich9 Studien
Sleep & insomniaKann die subjektive Schlafqualität verbessern (kleine Studien, hohes Verzerrungsrisiko) · Erste Nächte · Kann ein schnelleres Einschlafen unterstützen; die Evidenz beim Menschen ist begrenzt und indirekt · 30-60 Minuten · Verbessert die subjektive Schlafqualität und reduziert die Müdigkeit am Folgetag · 1-2 Wochen
Energy & fatigueWeniger Tagesmüdigkeit durch besseren Schlaf · 1 Woche
Überwiegend Mechanismus / Beobachtung3 Studien
Neuroprotection & brain aging
Zu wenige bewertete Studien1 Studie
Safety profile
Zu wenige bewertete Studien1 Studie
In Zahlen
Aus 16 Studien mit messbaren Effekten gezogen
Wahrscheinlich echte Effekte
100%
über Studien hinweg
Untersuchte Personen
1,610
typische Studie: 20 Personen
Stärkste Designs
20
5 gepoolt, 15 randomisiert
Zeigte Nutzen
100%
6/6 Studien
Wie lange Studien liefen
1–3 Monate
1
3+ Monate
1
Untersuchte Populationen
Patients with schizophrenia3
Adults with sleep issues1
Healthy recreationally active young men and women1
General population1
Aktives Forschungsgebiet
17 Studien in den letzten 5 Jahren · Neueste Meta-Analyse: 2025
200520152026
1Overall clinical symptoms in schizophreniaMeta-AnalyseCited 34×n=326 · medium study2020
The meta-analysis suggests that sarcosine may be associated with treatment effect on overall clinical symptoms in patients with schizophrenia but not cognitive functions.
Chang CH et al. · Journal of psychopharmacology (Oxford, England) (2020)
Groß Nutzen
← SchlechterKein EffektBesser →
Likely real
Sarcosine use achieved more significant effects than the use of its comparators in relieving overall clinical symptoms (SMD = 0.51, CI = 0.26-0.76, p < 0.01).
Moreover, studies with the low Positive and Negative Syndrome Scale range of 70-79 showed significant effect size (ES)s of 0.67 (95% CI: 0.03-1.31, p = 0.04).
In addition, trials enrolling patients with stable clinical symptoms had significant ESs: 0.53 (95% CI: 0.21-0.85, p < 0.01).
2Systematische ÜbersichtCited 14×n=34 · small study2024
This systematic-review examined the effects of Glycine.
Soh J et al. · GeroScience (2024)
The nervous system demonstrated the most positive effects, including improved psychiatric symptoms from longer-term glycine administration in psychiatric populations.
While longer-term glycine administration improved sleep in healthy populations, these studies had small sample sizes with a high risk of bias.
Larger and long-term studies with more robust study designs in healthy populations to examine the effects of glycine administration on preventing, delaying or reversing the ageing process are warranted.
Pooled effect sizes were determined with standardized mean differences (SMD), random effects adjusted by false discovery rate, and heterogeneity was examined by I2 statistics.
Other parameters studied were not altered.
Our findings show depletion of the glutamatergic system and emphasize the importance of understanding glutamate-mediated neurotoxicity in AD.
5Effect of glutamatergic drugs on schizophrenia symptomsMeta-AnalyseCited 61×n=132 · medium study2006
In general, all glutamatergic drugs appeared to be ineffective in further reducing positive symptoms of the disease when added to the existing antipsychotic treatment.
Tuominen HJ et al. · The Cochrane database of systematic reviews (2006)
Groß Nutzen
← SchlechterKein EffektBesser →
Likely real
NMDA receptor co-agonists glycine and D-serine showed some effects in reducing the negative symptoms of schizophrenia (n=132, SMD -0.66, CI -1.0 to -0.3, p=0.0004), but the magnitude of the effect was moderate.
Available rating scale data on positive symptoms and cognitive functioning did not indicate a statistically significant effect of glycine or D-serine.
In general, all glutamatergic drugs appeared to be ineffective in further reducing positive symptoms of the disease when added to the existing antipsychotic treatment.
6Negative symptoms of schizophreniaMeta-AnalyseCited 157×n=132 · medium study2005
In the current limited data set, a moderate amelioration of negative symptoms of schizophrenia was found, but no other statistically significant beneficial effects on symptoms of schizophrenia.
Tuominen HJ et al. · Schizophrenia research (2005)
Groß Nutzen
← SchlechterKein EffektBesser →
Likely real
NMDA receptor co-agonists glycine and D-serine are effective in reducing negative symptoms (N = 132, fixed effect model SMD = -0.66, 95% CI -1.02 to -0.29, p = 0.0004) of schizophrenia, the magnitude of the effect is moderate.
D-Cycloserine, a partial agonist of NMDA receptors, is less effective towards negative symptoms (N = 119, fixed effect model SMD = -0.11, 95% CI -0.48 to 0.25, p = 0.6).
Available derived data on cognitive functioning do not indicate a significant effect of glycine or D-serine (N = 80, random effect model WMD = -2.79, 95% CI -6.17 to 0.60, p = 0.11).
7Muscle connective protein synthesis ratesRCTCited 1×n=21 · very small study2025
The ingestion of a single bolus of collagen hydrolysate or free amino acids substantially increases circulating amino acids concentrations, particularly glycine, but does not further increase myofibrillar or muscle connective protein synthesis rates at rest or during recovery from exercise in healthy, recreationally active young men and women.
Aussieker T et al. · Medicine and science in sports and exercise (2025)
8Sleep onset latencyRCTCited 21×n=9 · very small study2023
Data demonstrate that using the proposed blend of novel nutritional ingredients during free living conditions reduced sleep onset latency, increased total sleep duration, and increased sleep efficiency, leading to reduced perceptions of morning sleepiness.
Langan-Evans C et al. · Medicine and science in sports and exercise (2023)
Spürbar Nutzen
← SchlechterKein EffektBesser →
Likely real
The intervention trial reduced sleep onset latency (-24 ± 25 min; P = 0.002), increased total sleep time (22 ± 32 min; P = 0.01), and increased sleep efficiency (2.4% ± 3.9%; P = 0.03), while also reducing morning sleepiness ( P = 0.02).
Throughout the study, 75% of participants remained blinded to sleep assessment as a primary outcome measure, with 56% subjectively indicating improved sleep during the intervention trial.
Data demonstrate that using the proposed blend of novel nutritional ingredients during free living conditions reduced sleep onset latency, increased total sleep duration, and increased sleep efficiency, leading to reduced perceptions of morning sleepiness.
9Facial skin moisture and elasticityRCTCited 71×2016
This study demonstrated that the use of the collagen hydrolysate with a higher content of Pro-Hyp and Hyp-Gly led to more improvement in facial skin conditions, including facial skin moisture, elasticity, wrinkles and roughness.
Inoue N et al. · Journal of the science of food and agriculture (2016)
This study demonstrated that the use of the collagen hydrolysate with a higher content of Pro-Hyp and Hyp-Gly led to more improvement in facial skin conditions, including facial skin moisture, elasticity, wrinkles and roughness.
11Communication and Symbolic Behavior Scales Developmental ProfileRCTCited 132×n=187 · medium study2023
This rct examined the effects of Glycine.
Neul JL et al. · Nature medicine (2023)
Spürbar Nutzen
← SchlechterKein EffektBesser →
Likely real
For the key secondary efficacy endpoint, LSM change from baseline to week 12 in the Communication and Symbolic Behavior Scales Developmental Profile Infant-Toddler Checklist Social Composite score was -0.1 versus -1.1 (P = 0.0064; effect size, 0.43).
Common treatment-emergent adverse events included diarrhea (80.6% for trofinetide versus 19.1% for placebo), which was mostly mild to moderate in severity.
Significant improvement for trofinetide compared with placebo was observed for the coprimary efficacy endpoints, suggesting that trofinetide provides benefit in treating the core symptoms of Rett syndrome.
In conclusion, whey protein supplementation enhances whole body anabolism, and may improve acute recovery of exercise performance after a strenuous bout of resistance exercise.
West DWD et al. · Nutrients (2017)
Net protein balance tended to improve in PRO (P = 0.064; effect size (ES) = 0.61, PRO vs.
Over 24 h, net balance was enhanced in PRO (P = 0.036) but not in CHO (P = 0.84; ES = 0.69, PRO vs.
At 10 h, there were small-to-moderate effects for enhanced recovery of the MVC (ES = 0.56), mean power (ES = 0.49), and CMJ variables (ES: 0.27-0.49) in PRO.
CP supplementation did not influence sleep quantity, latency, or efficiency, but reduced awakenings and improved cognitive function in physically active males with sleep complaints.
Thomas C et al. · European journal of nutrition (2024)
CP supplementation did not influence sleep quantity, latency, or efficiency, but reduced awakenings and improved cognitive function in physically active males with sleep complaints.
Ingestion of a whey (25 g) plus collagen (5 g) protein blend increases both myofibrillar and muscle connective protein synthesis rates at rest and further increases myofibrillar but not muscle connective protein synthesis rates during recovery from exercise in recreationally active, young men.
Aussieker T et al. · Medicine and science in sports and exercise (2025)
In addition, myofibrillar protein synthesis rates were higher in BLEND compared with PLA in both the rested (0.038 ± 0.008 and 0.031 ± 0.006%·h -1 , respectively; P < 0.05) and exercised (0.052 ± 0.011 and 0.039 ± 0.009%·h -1 , respectively; P < 0.01) leg.
Muscle connective protein synthesis rates were higher in BLEND compared with PLA in the rested (0.062 ± 0.013 and 0.051 ± 0.010%·h -1 , respectively; P < 0.05), but not the exercised (0.090 ± 0.021 and 0.079 ± 0.016%·h -1 , respectively; P = 0.11) leg.
Ingestion of a whey (25 g) plus collagen (5 g) protein blend increases both myofibrillar and muscle connective protein synthesis rates at rest and further increases myofibrillar but not muscle connective protein synthesis rates during recovery from exercise in recreationally active, young men.
16Collagen synthesisRCTCited 143×n=8 · very small study2017
These data suggest that adding gelatin to an intermittent exercise program improves collagen synthesis and could play a beneficial role in injury prevention and tissue repair.
Shaw G et al. · The American journal of clinical nutrition (2017)
These data suggest that adding gelatin to an intermittent exercise program improves collagen synthesis and could play a beneficial role in injury prevention and tissue repair.
This trial was registered at the Australian New Zealand Clinical Trials Registry as ACTRN12616001092482.
17Glutathione deficiency and oxidative stressRCTCited 118×n=12 · very small study2023
GlyNAC supplementation in OA for 16-weeks was safe and well-tolerated.
Kumar P et al. · The journals of gerontology. Series A, Biological sciences and medical sciences (2023)
GlyNAC supplementation in OA for 16-weeks was safe and well-tolerated.
By combining the benefits of glycine, NAC and GSH, GlyNAC is an effective nutritional supplement that improves and reverses multiple age-associated abnormalities to promote health in aging humans.
Song Y et al. · Diabetes, obesity & metabolism (2026)
In addition to modulating the aging process, urea cycle amino acids exhibit altered levels in kidney diseases and frequently serve as indicators of disease severity.
Furthermore, we propose several promising therapeutic strategies, including nutritional interventions directed at specific amino acids and pharmacological therapies that target the modulation of amino acid metabolism.
The relationship between amino acid availability and aging in kidney disease is not merely linear but involves a complex and dynamic interplay.
20Muscle preservation and sarcopenia managementSystematische Übersicht2026
Medicinal plants offer a multifaceted approach to muscle preservation, with promising relevance for aging, metabolic dysfunction, and disease-related sarcopenia.
Yazdanpanah Z et al. · Phytomedicine : international journal of phytotherapy and phytopharmacology (2026)
Medicinal plants offer a multifaceted approach to muscle preservation, with promising relevance for aging, metabolic dysfunction, and disease-related sarcopenia.
Despite robust preclinical evidence, clinical translation is limited by methodological variability and dosing challenges.