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Haw6.5
Hawthorn – Forschung
Hilft vermutlich
64 begutachtete Studien
Was die Evidenz sagt
Hilft vermutlich
Hawthorn half in etwa der Hälfte (4/6) der Studien, die einen Effekt gemessen haben — vielversprechend, aber nicht einhellig.
Die meiste Evidenz stammt aus hochwertigen Meta-Analysen und randomisierten Studien, veröffentlicht 2001–2026 mit einer typischen Studiengröße von 120 Teilnehmenden.
Basierend auf 64 Studien · 8 Meta-Analysen · 38 RCTs · 43,293 Teilnehmende insgesamt
Konfidenz
Hohe Konfidenz
Was die Studien gefunden haben
4geholfen2unklar· 58 weitere ohne bewertete Effektdaten
Nach Outcome
Heart & blood pressureVerbesserte Herzfunktion und Blutdruckunterstützung innerhalb von 4-8 Wochen · 4-8 weeks
Hilft vermutlich32 Studien
Therapeutic & clinical
Überwiegend Mechanismus / Beobachtung9 Studien
InflammationVerbesserte Herzfunktion und körperliche Leistungsfähigkeit · 6-12 weeks
Überwiegend Mechanismus / Beobachtung5 Studien
Safety profile
Überwiegend Mechanismus / Beobachtung5 Studien
Liver health
Überwiegend Mechanismus / Beobachtung3 Studien
Cholesterol & lipidsVerbesserte Herzfunktion und Blutdruckunterstützung innerhalb von 4-8 Wochen · 4-8 weeks
Zu wenige bewertete Studien2 Studien
Anxiety & stress
Zu wenige bewertete Studien2 Studien
Skin health
Zu wenige bewertete Studien2 Studien
Energy & fatigue
Zu wenige bewertete Studien2 Studien
In Zahlen
Aus 28 Studien mit messbaren Effekten gezogen
Wahrscheinlich echte Effekte
33%
über Studien hinweg
Untersuchte Personen
43k
typische Studie: 120 Personen
Stärkste Designs
46
8 gepoolt, 38 randomisiert
Zeigte Nutzen
67%
4/6 Studien
Wie lange Studien liefen
1–4 Wochen
2
Untersuchte Populationen
NAFLD patients3
Heart failure patients2
General population2
Stroke patients1
Aktives Forschungsgebiet
25 Studien in den letzten 5 Jahren · Neueste Meta-Analyse: 2022
200120132026
1Stroke rehabilitation efficacyMeta-AnalyseCited 37×n=6,339 · very large study2022
Our results indicate that the combined use of CM and WM could be more efficacious in stroke rehabilitation compared with the use of WM therapy alone.
Zhong LL et al. · Stroke and vascular neurology (2022)
Our results indicate that the combined use of CM and WM could be more efficacious in stroke rehabilitation compared with the use of WM therapy alone.
However, most studies were short in duration (2 to 4 weeks) and prone to different types of biases, which prevents making any conclusion regarding the long-term effects and raises concerns regarding true efficacy in context of high likelihood of Hawthorn bias.
So, more randomised controlled trials with more rigorous design and longer duration of treatment and follow-up need to be conducted to compare WM alone versus WM and CM combined.
2Blood lipid, glucose levels and liver function in NAFLDSystematische ÜbersichtCited 9×n=829 · large study2023
In patients with NAFLD, dietary intervention using medicinal and food homologous substances can ameliorate blood lipid and blood glucose levels and liver enzymes to some extent.
Zhang Q et al. · Lipids in health and disease (2023)
In patients with NAFLD, dietary intervention using medicinal and food homologous substances can ameliorate blood lipid and blood glucose levels and liver enzymes to some extent.
3Maximal workload capacity in heart failureMeta-Analysen=632 · large study2003
For the physiologic outcome of maximal workload, treatment with hawthorn extract was more beneficial than placebo (weighted mean difference, 7 Watt; 95% confidence interval [CI]: 3 to 11 Watt; P < 0.01; n = 310 patients).
Pittler MH et al. · The American Journal of Medicine (2003)
Spürbar Nutzen
← SchlechterKein EffektBesser →
Eight trials including 632 patients with chronic heart failure (NYHA classes I to III) provided data suitable for meta-analysis.
Maximal workload improved by a weighted mean difference of 7 Watt (95% CI 3 to 11) versus placebo.
Symptoms such as dyspnea and fatigue improved significantly with hawthorn treatment compared with placebo.
4NAFLD treatment efficacyMeta-AnalyseCited 67×n=25,661 · very large study2012
In conclusion, TCM is of modest benefit to the treatment of NAFLD.
Shi KQ et al. · Molecular biology reports (2012)
Comparing with western medicines mentioned above, TCM had a better effect on the normalization of alanine aminotransferase and disappearance of radiological steatosis in the treatment of NAFLD.
Furthermore, 246 kinds of Chinese herbs were included in our present study, with an average of 10 herbs (range 1-31) in each formulation.
Hawthorn Fruit (321 times in 17,670 patients) was the most often used herb in the treatment of NAFLD.
11Adverse eventsSystematische ÜbersichtCited 48×n=7,311 · very large study2006
Moreover, the unsupervised use of this drug can be associated with problems, especially if given with concomitant medications.
Daniele C et al. · Drug safety (2006)
The extracts most used in the clinical trials were WS 1,442 (extract of hawthorn standardised to 18.75% oligomeric procyanidins) and LI 132 (extract of hawthorn standardised to 2.25% flavonoids).
In the identified trials, the most frequent adverse events were dizziness (n = 6), nausea (n = 5), fall (n = 2), gastrointestinal haemorrhage (n = 2), circulation failure (n = 2) and erythematous rash (n = 2).
This review summarizes the recently published research, preclinical data, brief phytochemistry, and pharmacology on 5 Maloideae genera to underscore their potential as adjunctive therapy against obesity and metabolic disorder and future research opportunities.
Traditional herbal medicines and functional foods have become the subject of global importance, with both medical and economic implications.
The apple subfamily Maloideae includes commercially and medicinally valuable fruits like apples, pears, loquat, quince, and hawthorn, and many other plants.
This subfamily has a distinctive fruit, the pome, with characteristic antioxidant content.
This short review focuses on six herbs that can constitute an interesting and potential therapeutic option in the management of cardiovascular disorders.
Witkowska A, Gryn-Rynko A, Syrkiewicz P, Kitala-Tańska K, Majewski MS. · Nutrients (2024)
Such herbal-originated medication therapy may include Morus alba L. (white mulberry), Elaeagnus rhamnoides (L.) A.
Nelson (sea-buckthorn), Allium sativum L. (garlic), Convallaria majalis L. (lily of the valley), Leonurus cardiaca L. (motherwort), and Crataegus spp. (hawthorn).
Valuable herbal raw materials include leaves, fruits, seeds, and even thorns.
The herbal supplement is safe and enhances mood, reduces subjective anxiety, and improves cognition under stress, though cognitive effects are variable without stress exposure.The study was registered on clinicaltrials.gov (identifier: NCT05757050).
Dodd F et al. · Journal of psychopharmacology (Oxford, England) (2025)
A higher proportion of subjects experienced ⩾30% gains in social satisfaction scores after 7 days.
The herbal supplement is safe and enhances mood, reduces subjective anxiety, and improves cognition under stress, though cognitive effects are variable without stress exposure.The study was registered on clinicaltrials.gov (identifier: NCT05757050).