Wir verwenden standardmäßig essenzielle Cookies (Anmeldung, deine gespeicherten Ziele/Stacks). Mit deiner Erlaubnis aktivieren wir außerdem datenschutzfreundliche Analytik (Vercel Web Analytics, anonyme Ladezeit-Metriken) und Fehler-Replay-Diagnostik (Sentry — DOM-Snapshots nur, wenn ein Fehler auftritt), damit wir Bugs schneller beheben können. Mehr über Cookies erfahren
Lhe3.0
L. helveticus R0052 + B. longum R0175 – Forschung
Überwiegend Mechanismus / Beobachtung
9 begutachtete Studien
Was die Evidenz sagt
Überwiegend Mechanismus / Beobachtung
Die meisten Studien zu L. helveticus R0052 + B. longum R0175 sind mechanistisch oder beobachtend statt RCTs, die einen klinischen Effekt messen — betrachte die Ergebnisse als vorläufig.
Die meiste Evidenz stammt aus mittelwertigen randomisierten Studien, veröffentlicht 2008–2025 mit einer typischen Studiengröße von 78 Teilnehmenden.
Basierend auf 9 Studien · 5 RCTs · 359 Teilnehmende insgesamt
Konfidenz
Mittlere Konfidenz
Nach Outcome
Mood & depressionA meaningful drop in depression scores over 8 weeks in people with diagnosed major depressive disorder; no effect demonstrated in people who are not depressed · 4-8 weeks
Überwiegend Mechanismus / Beobachtung6 Studien
Anxiety & stress responseNot established — the one independent trial in healthy adults found no effect on anxiety, and the founding psychotropic trial's HADS-anxiety result did not reach significance · 4 weeks
Überwiegend Mechanismus / Beobachtung5 Studien
Stress-related GI symptoms
Überwiegend Mechanismus / Beobachtung3 Studien
BDNF & neurochemical biomarkers
Überwiegend Mechanismus / Beobachtung3 Studien
Safety profile
Zu wenige bewertete Studien2 Studien
Aktives Forschungsgebiet
4 Studien in den letzten 5 Jahren
200820162025
1RCTn=135 · medium study2023
Einfach gesagt: The only independent, non-industry trial of this combination found no significant effect on any pre-specified outcome in healthy adults.
Morales-Torres R et al. · Nutrients (2023)
NULL on the whole sample: 'no significant effects of probiotic intake in whole sample outcomes'
Pre-specified outcomes covered wellbeing, quality of life, emotional regulation, anxiety, mindfulness and interoceptive awareness — none moved
The only positive result was a POST HOC linear mixed-effects interaction between high Healthy Behaviors scores and probiotic intake, predicting effects on anxiety, emotional regulation and mindfulness
Einfach gesagt: The prescription of prebiotics and probiotics with the lifestyle measures seems interesting for the management of obesity especially if it is sarcopenic, in addition to the improvement of metabolic parameters and obesity-related psychiatric disorders.
Ben Othman R et al. · Endocrinology, diabetes & metabolism (2023)
All three groups showed a significant decrease in weight, BMI and waist circumference with p < .05.
Only the prebiotic and probiotic group showed a significant decrease in fat mass (p = .001) and a significant increase in muscle strength with p = .008 and .004, but the differences were not significant between the three groups.
Our results showed also a significant decrease in insulinemia and HOMA-IR in the prebiotic group compared to the diet-alone group (p = .03; p = .012) and the probiotic group showed a significant decrease in fasting blood glucose compared to the diet alone group (p = .02).
Einfach gesagt: The one clearly positive trial: depression scores nearly halved on the combination in patients with diagnosed MDD, at p=0.042.
Kazemi A et al. · Clin Nutr (2019)
BDI score fell 17.39 to 9.1 on the probiotic vs 18.18 to 15.55 on placebo and 19.72 to 14.14 on prebiotic (p=0.042)
110 patients with major depressive disorder randomised, but only 81 completed — roughly 26% attrition (28 probiotic, 27 prebiotic, 26 placebo)
Kynurenine/tryptophan ratio showed NO significant between-group difference in the primary comparison; it only reached significance versus placebo after adjusting for serum isoleucine (p=0.048)
Einfach gesagt: The founding Probio'Stick trial: significant relief of abdominal pain and nausea, and explicitly no effect on psychological symptoms or sleep.
Diop L, Guillou S, Durand H · Nutr Res (2008)
Significantly reduced two stress-induced gastrointestinal symptoms — abdominal pain and nausea/vomiting — in both intention-to-treat and per-protocol populations
EXPLICIT NULL on everything else: the probiotic 'did not significantly modify the other physical and psychological symptoms and sleep problems' induced by stressful life events
Einfach gesagt: The paper that made this combination famous — and it reports no sample size, no effect sizes, and no confidence intervals for the human arm.
Messaoudi M et al. · Br J Nutr (2011)
The abstract states NO sample size, NO effect sizes and NO confidence intervals for the human trial
Roughly seven findings reported at p<0.05 across multiple instruments (HSCL-90 global severity, somatisation, depression, anger-hostility; HADS global; CCL problem-solving; 24h urinary free cortisol) with no correction for multiplicity
HADS-anxiety was reported at P<0.06 — that is, NOT statistically significant, despite the anxiolytic framing
Einfach gesagt: Negative on gastrointestinal symptoms — though with only 5 participants in the active arm, it proves very little either way.
Wiącek J et al. · Int J Mol Sci (2025)
NO improvement in gastrointestinal symptoms on the Rome IV questionnaire
Faecal metabolome shifted in the probiotic group (permutation test p=0.026), including a reduction in (2RS)-2-(4-hydroxyphenyl)propionic acid (p=0.023)
Of 51 volunteers, 26 female dancers were randomised and only 16 were analysed — probiotic n=5, placebo n=11