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Lre6.0
L. reuteri DSM 17938 – Forschung
Überwiegend Mechanismus / Beobachtung
58 begutachtete Studien
Was die Evidenz sagt
Überwiegend Mechanismus / Beobachtung
Die meisten Studien zu L. reuteri DSM 17938 sind mechanistisch oder beobachtend statt RCTs, die einen klinischen Effekt messen — betrachte die Ergebnisse als vorläufig.
Die meiste Evidenz stammt aus hochwertigen Meta-Analysen und randomisierten Studien, veröffentlicht 2010–2026 mit einer typischen Studiengröße von 57 Teilnehmenden.
Basierend auf 58 Studien · 8 Meta-Analysen · 18 RCTs · 14,148 Teilnehmende insgesamt
Konfidenz
Hohe Konfidenz
Nach Outcome
Diarrhoea & digestive healthShortens acute infectious diarrhoea in children by roughly 25 hours; modest reduction in functional abdominal pain. The headline colic benefit applies to breastfed infants, not adults · 1-3 weeks
Überwiegend Mechanismus / Beobachtung17 Studien
Infant colic & crying
Überwiegend Mechanismus / Beobachtung13 Studien
Safety profile
Überwiegend Mechanismus / Beobachtung9 Studien
Immune support
Überwiegend Mechanismus / Beobachtung5 Studien
Preterm infants & NEC
Überwiegend Mechanismus / Beobachtung4 Studien
Oral & dental health
Überwiegend Mechanismus / Beobachtung4 Studien
Functional abdominal pain
Zu wenige bewertete Studien1 Studie
Women's health
Zu wenige bewertete Studien1 Studie
Cholesterol & lipids
Zu wenige bewertete Studien1 Studie
Aktives Forschungsgebiet
40 Studien in den letzten 5 Jahren · Neueste Meta-Analyse: 2023
201020182026
1Meta-Analysen=12,127 · very large study2020
Einfach gesagt: Probiotics probably make little or no difference to the number of people who have diarrhoea lasting 48 hours or longer, and we are uncertain whether probiotics reduce the duration of diarrhoea.
Collinson S et al. · The Cochrane database of systematic reviews (2020)
Effect size was similar in the sensitivity analysis and marked heterogeneity persisted.
Effect size was similar and marked heterogeneity persisted in pre-specified subgroup analyses of the primary outcomes that included all studies.
In six trials (433 participants) of Lactobacillus reuteri, there was consistency amongst findings (I² = 0%), but risk of bias was present in all included studies.
Einfach gesagt: In this study, L. reuteri-containing formula was associated with improved digestive tolerance and behavioral patterns.
Happy Tummy Consortium et al. · Nutrients (2023)
Compared with FFI-Std, FFI + LR had lower reports of difficulty in passing stools (11% vs. 22%; adjusted-odds ratio (OR) (95%CI) = 0.46 (0.31-0.68)), fewer hard stools (mean difference = -0.12 (-0.21, -0.02)) and less physician-confirmed colic (OR = 0.61 (0.45-0.82)), and similar to BFI.
The IGSQ composite scores (adjusted mean ± SE) in FFI + LR (22.17 ± 0.39) was significantly lower than in FFI-Std (23.41 ± 0.37) and similar to BFI (22.34 ± 0.30;), indicating better GI tolerance in FFI + LR than in FFI-Std.
In this study, L. reuteri-containing formula was associated with improved digestive tolerance and behavioral patterns.
Einfach gesagt: Further well-designed trials are warranted.
Kilchoer B et al. · Nutrients (2020)
Twenty RCTs, involving 1171 overweight and obese adults, of which 36% were females, with or without comorbidities, were included.
Results did neither favor omega-3 (effect size -1.17; weighted mean difference (WMD) (95% confidence interval (CI)) -3.62, 1.28; p < 0.001) nor resveratrol supplementation (0.18; 95% CI -1.08, 1.43; p = 0.27).
The findings of the qualitatively summarized RCTs suggested that catechins (n = 1), Lactobacillus reuteri (n = 1), and carnitine (n = 1) may reduce liver fat.
Einfach gesagt: Further examination of larger sample sizes is needed to confirm these findings.
Liu J et al. · Nutrition research (New York, N.Y.) (2023)
The results showed that L. reuteri consumption significantly reduced total cholesterol (TC) by -0.26 mmol/L compared with the control group.
Subgroup analysis showed a significant reduction in TC when participants were <55 years old, had a body mass index between 25 and 30, or had hypercholesterolemia.
Strain subgroup analysis showed that L. reuteri NCIMB 30242 significantly reduced TC and LDL-C.
Einfach gesagt: Pooling raw participant data from four double-blind trials, this strain nearly doubled treatment success in breastfed colicky infants, with a number needed to treat of 2.6.
Sung V et al. · Pediatrics (2018)
Day-21 adjusted mean difference in cry/fuss time: -25.4 min/day (95% CI -47.3 to -3.5)
Day-21 treatment success adjusted incidence ratio 1.7 (95% CI 1.4-2.2)
Number needed to treat in breastfed infants: 2.6 (95% CI 2.0-3.6)
Einfach gesagt: The largest single trial was null and directionally adverse — infants given the probiotic cried and fussed 49 minutes more per day than those on placebo.
Sung V et al. · BMJ (2014)
Probiotic group cried/fussed 49 minutes MORE than placebo at 1 month (95% CI 8 to 90, P=0.02)
Excess was mainly more fussing, especially in formula-fed infants
No differences in sleep, maternal mental health, faecal microbial diversity, E. coli colonisation, or calprotectin
Einfach gesagt: Further good quality clinical studies and qualitative research would further our understanding of the role these health supplements may play in future treatment protocols.
Pellow J et al. · Complementary therapies in medicine (2020)
Combination formulas may also be beneficial, particularly specific probiotic complexes, a mixture of vitamin D3, quercetin and Perilla frutescens, as well as the combination of vitamin D3 and L. reuteri.
Owing to the paucity of good quality evidence, recommendations pertaining to the use of health supplements for allergic rhinitis should involve a shared decision-making process between the healthcare provider and the patient, taking into account their efficacy, safety and cost.
Further good quality clinical studies and qualitative research would further our understanding of the role these health supplements may play in future treatment protocols.
Einfach gesagt: We also summarize the available scientific evidence on using Limosilactobacillus reuteri (L. reuteri) as a critical probiotic for H. pylori treatment and discuss its clinical research and application from an evidence-based perspective.
Liang B et al. · Frontiers in cellular and infection microbiology (2022)
Numerous in vitro studies, animal studies, and clinical observations have demonstrated that probiotics have the advantage of reducing side effects and increasing eradication rates in adjuvant anti-H. pylori therapy and are a valuable supplement to conventional therapy.
In this paper, we focus on the risk, status, prevention, control, and treatment of H. pylori infection and review international consensus guidelines.
Einfach gesagt: The results of this trial will be used to support a phase 1 clinical trial in neonates, with the goal of utilizing L. reuteri in its biofilm state to prevent NEC in premature neonates in the future.
Ragan MV et al. · Frontiers in cellular and infection microbiology (2022)
Using a rat model of NEC, L. reuteri administered in its biofilm state significantly increases animal survival, reduces the incidence of NEC, preserves gut barrier function, and decreases intestinal inflammation.
In a murine model of Clostridiodes difficile infection, L. reuteri administered in its biofilm state decreases colitis when administered either before or after C. difficile induction, demonstrating both prophylactic and therapeutic efficacy.
There are currently no FDA-approved probiotic preparations for human use.
Einfach gesagt: However, the detailed mechanisms of certain strains remain unclear.
Li L et al. · International journal of molecular sciences (2026)
Herein, we summarize the current progress of research on the probiotic properties of these strains in terms of their ability to protect against harmful pathogens, maintain intestinal health, and improve disease outcomes.
They have been shown to ameliorate intestinal inflammation in animal models and provide protective effects against various healthy issues in humans, including diarrhea, constipation, colorectal cancer, obesity, and liver diseases.
However, the detailed mechanisms of certain strains remain unclear.
Einfach gesagt: This study showed that the use of L. reuteri DSM 17938 and/or agave inulin improved the stool characteristics such as the history of painful defecation and the presence of fecal mass in the rectum against placebo in children with cerebral palsy and chronic constipation.
García Contreras AA et al. · Nutrients (2020)
The probiotic group showed a significant decrease in stool pH (p = 0.014).
Stool consistency improved in the prebiotic group (p = 0.008).
The probiotic, prebiotic, and synbiotic groups showed a significant improvement in the history of excessive stool retention, the presence of fecal mass in the rectum, and the history of painful defecation.
Einfach gesagt: The findings suggest that a dietary intervention targeted toward restoring the gut microbiome can improve host-microbiome interactions that likely underpin chronic pathologies, which can guide dietary recommendations and the development of therapeutic and nutritional strategies.
Li F et al. · Cell (2025)
Considerable cardiometabolic benefits were observed independently of L. reuteri administration, several of which could be accurately predicted by baseline and diet-responsive microbiome features.
The findings suggest that a dietary intervention targeted toward restoring the gut microbiome can improve host-microbiome interactions that likely underpin chronic pathologies, which can guide dietary recommendations and the development of therapeutic and nutritional strategies.
Einfach gesagt: Future research should address these challenges to support the use of L. reuteri in functional foods and therapeutic products.
Berenice LE et al. · Comprehensive reviews in food science and food safety (2026)
In addition to strain-specific functional activities, this review examines how coating material, processing method, and strain affect release kinetics, functional activities, and viability.
However, data on the stability of encapsulated L. reuteri during industrial processing, storage, and health claim validation under regulatory frameworks remain limited.
Future research should address these challenges to support the use of L. reuteri in functional foods and therapeutic products.
15Systematische Übersichtn=10 · very small study2021
Einfach gesagt: Researchers should perform high-quality RCT, evaluating single strains without combinations, in order to observe the microbiological benefits as adjunctive treatment of PD.
Villafuerte KRV et al. · Beneficial microbes (2021)
Probiotics adjuvant to periodontal therapy reduces periodontopathogenic species in a greater proportion, compared only to periodontal therapy.
Especially the Lactobacillus reuteri strain, without combination with other strains, offered a greater reduction in pathogenic bacteria associated with greater destruction of periodontal tissues and deep periodontal pockets.
Researchers should perform high-quality RCT, evaluating single strains without combinations, in order to observe the microbiological benefits as adjunctive treatment of PD.
Einfach gesagt: According to our results, L. reuteri PBS072 and B. breve BB077 are potential candidates that are able to improve stress resilience in the postpartum period.
Vicariotto F et al. · Nutrients (2023)
Results: At days 45 and 90, the probiotic treatment significantly ameliorated the mothers' mood compared to the control treatment (p < 0.001).
Likewise, the breastfeeding quality and the baby's cries significantly improved in the probiotic group (p < 0.001).
Conclusions: Microbiota alterations could influence a post-delivery woman's mental state.
Einfach gesagt: In combination with reassurance and guidance, the nutritional intervention was shown to be effective in infants with FGIDS in real-life circumstances.
Vandenplas Y et al. · Nutrients (2021)
The formula was shown to decrease FGIDs within three days (decrease of CoMiSS -1.29 (3.15) (mean (SD), p < 0.0001) followed by an improvement of quality of life after seven days (increase QUALIN +1.4 (7.8); p: 0.008).
Constipation decreased from 18.8% to 6.5% within three days.
The efficacy was evaluated with the Cow Milk-associated Symptom Score (CoMiSS®) and quality of life with the QUALIN score.
Einfach gesagt: This review focuses on the probiotic effects of L. reuteri on gut homeostasis via certain signaling pathways, and emphasizes the importance of these probiotics as a prospective treatment against several digestive system diseases.
Peng Y et al. · Frontiers in cellular and infection microbiology (2023)
This review focuses on the probiotic effects of L. reuteri on gut homeostasis via certain signaling pathways, and emphasizes the importance of these probiotics as a prospective treatment against several digestive system diseases.
Published in Frontiers in cellular and infection microbiology (2023)
Einfach gesagt: The supplementation with L. reuteri 4659 together with bowel rest and fluids significantly reduced both blood and faecal inflammatory markers compared to the placebo group.
Ojetti V et al. · European journal of gastroenterology & hepatology (2022)
C-RP value, after 72 h, decreased by 58.8% in the probiotic group and by only 40% in the placebo group (P < 0.05).
Calprotectin levels, after 72 h, decreased by 17% in the probiotic group and by only 10.6% in the control group (P < 0.05).
The supplementation with L. reuteri 4659 together with bowel rest and fluids significantly reduced both blood and faecal inflammatory markers compared to the placebo group.
In summary, consumption of EYCF containing a L. reuteri + GOS synbiotic improves musculoskeletal development in toddlers via modulation of microbiota composition and function.
These results provide insights on gut-musculoskeletal crosstalk during early life.