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Lyc4.5
Lycopene – Forschung
Überwiegend Mechanismus / Beobachtung
7 begutachtete Studien
Was die Evidenz sagt
Überwiegend Mechanismus / Beobachtung
Die meisten Studien zu Lycopene sind mechanistisch oder beobachtend statt RCTs, die einen klinischen Effekt messen — betrachte die Ergebnisse als vorläufig.
Die meiste Evidenz stammt aus hochwertigen Meta-Analysen und randomisierten Studien, veröffentlicht 2015–2026 mit einer typischen Studiengröße von 9,131 Teilnehmenden.
Basierend auf 7 Studien · 4 Meta-Analysen · 1 RCT · 704,710 Teilnehmende insgesamt
Konfidenz
Hohe Konfidenz
Nach Outcome
Heart & blood pressureReduzierter Marker für oxidativen Stress (MDA), jedoch kein signifikanter Effekt auf Cholesterin, Blutdruck oder Glukose in RCTs · Unklar
Zu wenige bewertete Studien1 Studie
Aktives Forschungsgebiet
4 Studien in den letzten 5 Jahren · Neueste Meta-Analyse: 2026
201520202026
1Meta-Analysen=9,131 · very large study2026
The effect appears more pronounced in men, highlighting potential sex-specific differences in carotenoid metabolism and cardiovascular risk modulation.
Cavero-Redondo I et al. · Nutrients (2026)
Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated via random effects models.
High circulating lycopene levels were significantly associated with low IMT (pooled OR = 0.70; 95% CI: 0.59-0.84; I2 = 65.7%).
The association was stronger in men (OR = 0.62; 95% CI: 0.45-0.84) than in women (OR = 0.74; 95% CI: 0.58-0.95).
This review integrates evidence across in vitro, in vivo, and human studies to identify key mechanisms of phthalate-induced neurotoxicity, including oxidative stress, neuroinflammation, endocrine disruption, epigenetic dysregulation, and impaired neuroplasticity, and evaluates pathway-specific neuroprotective actions of bioactive compounds while highlighting critical translational gaps.
Atanda OE et al. · Neurotoxicology (2026)
Despite these promising findings, challenges persist, including poor bioavailability, lack of standardized dosing, and limited human clinical trials.
A structured review of experimental and epidemiological studies was conducted using predefined inclusion criteria.
Across 42 studies (43,851 prostate cancer cases among ~692,000 participants), both dietary and circulating lycopene were associated with ~12% lower prostate cancer risk with a graded dose-response, but no association with advanced disease.
Rowles JL 3rd, Ranard KM, Smith JW, An R, Erdman JW Jr · Prostate Cancer Prostatic Dis (2017)
42 studies, 43,851 prostate cancer cases, 692,012 participants
Across 34 RCTs, lycopene/tomato consumption significantly lowered the oxidative-stress marker MDA but had no significant effect on cholesterol, triglycerides, blood pressure, glucose, or inflammatory markers.
Zamani M, Behmanesh Nia F, Ghaedi K, Mohammadpour S, Amirani N, Goudarzi K, et al. · Curr Pharm Des (2023)
Significant reduction in malondialdehyde (MDA), an oxidative-stress marker
No significant effect on TG, total/LDL/HDL cholesterol, fasting glucose
No significant effect on systolic/diastolic blood pressure, CRP, IL-6, TNF-α, or body weight
Pooling six RCTs, lycopene supplementation had no significant effect on circulating PSA overall (WMD -0.60 µg/L), though a reduction appeared in the subgroup with higher baseline PSA (≥6.5 µg/L).
Sadeghian M, Asadi M, Rahmani S, Sadeghi N, Hosseini SA, Zare Javid A · Nutr Cancer (2021)
6 RCTs in non-metastatic prostate cancer pooled
No significant overall effect on PSA (WMD -0.60, 95% CI -2.01 to 0.81 µg/L)
Significant reduction only in high-baseline-PSA subgroup (WMD -3.74 µg/L)
In 149 volunteers, a 12-week lycopene-rich tomato carotenoid complex significantly protected against UVB-induced skin erythema and upregulation of pro-inflammatory cytokines IL-6 and TNF-α versus placebo, though minimal erythemal dose did not differ.
7Systematische Übersichtn=3,418 · very large study2015
Among 44 randomized lifestyle-intervention trials, only a few low-risk-of-bias trials (including one supplementing soy, lycopene, selenium and CoQ10) showed benefit; heterogeneity prevented meta-analysis and most trials were underpowered.
Hackshaw-McGeagh LE, Perry RE, Leach VA, Qandil S, Jeffreys M, Martin RM, Lane JA · Cancer Causes Control (2015)
44 RCTs of diet/nutrition/activity in prostate cancer (3,418 patients)
Substantial heterogeneity prevented meta-analysis
A multi-nutrient trial including lycopene (with soy, selenium, CoQ10) showed benefit and low bias risk