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Lyc4.5
Lycopene – Forschung
Überwiegend Mechanismus / Beobachtung
42 begutachtete Studien
Was die Evidenz sagt
Überwiegend Mechanismus / Beobachtung
Die meisten Studien zu Lycopene sind mechanistisch oder beobachtend statt RCTs, die einen klinischen Effekt messen — betrachte die Ergebnisse als vorläufig.
Die meiste Evidenz stammt aus hochwertigen Meta-Analysen und randomisierten Studien, veröffentlicht 2015–2026 mit einer typischen Studiengröße von 206 Teilnehmenden.
Basierend auf 42 Studien · 12 Meta-Analysen · 13 RCTs · 819,038 Teilnehmende insgesamt
Konfidenz
Hohe Konfidenz
Nach Outcome
Heart & blood pressureReduzierter Marker für oxidativen Stress (MDA), jedoch kein signifikanter Effekt auf Cholesterin, Blutdruck oder Glukose in RCTs · Unklar
Überwiegend Mechanismus / Beobachtung3 Studien
BPH & lower urinary tract symptoms
Zu wenige bewertete Studien1 Studie
Safety profile
Zu wenige bewertete Studien1 Studie
Aktives Forschungsgebiet
34 Studien in den letzten 5 Jahren · Neueste Meta-Analyse: 2026
201520202026
1Meta-Analysen=9,131 · very large study2026
Einfach gesagt: The effect appears more pronounced in men, highlighting potential sex-specific differences in carotenoid metabolism and cardiovascular risk modulation.
Cavero-Redondo I et al. · Nutrients (2026)
Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated via random effects models.
High circulating lycopene levels were significantly associated with low IMT (pooled OR = 0.70; 95% CI: 0.59-0.84; I2 = 65.7%).
The association was stronger in men (OR = 0.62; 95% CI: 0.45-0.84) than in women (OR = 0.74; 95% CI: 0.58-0.95).
Einfach gesagt: However, the findings were derived from a small-scale meta-analysis in which the result was no longer statistically significant after the exclusion of one study.
Yoshida K, Nakazawa Y, Takahashi S. · Nutrients (2026)
A meta-analysis of four continuous (≥7 days) lycopene-containing product intake studies measuring flow-mediated dilation (FMD) ( n = 182) revealed a significant increase in FMD (MD = 1.36, 95% confidence interval: 0.20, 2.51, p = 0.02).
One study not included in the meta-analysis showed that 15 mg of lycopene intake for 8 weeks significantly increased the reactive hyperemia peripheral arterial tonometry index.
However, the findings were derived from a small-scale meta-analysis in which the result was no longer statistically significant after the exclusion of one study.
Einfach gesagt: Larger, high-quality randomized trials are needed to confirm these findings and clarify the role of lycopene in male reproductive health.
Viña I, Viña JR. · International journal of molecular sciences (2025)
Standardized mean differences (SMDs) were calculated for the key outcomes.
Lycopene supplementation significantly improved sperm concentration (SMD 0.33, 95% CI [0.02-0.65], p = 0.037) and nonprogressive motility (SMD 0.45, 95% CI [0.04-0.87], p = 0.032).
No statistically significant effects were observed on total motility, progressive motility, normal or abnormal morphology, semen volume, or DNA damage.
10Systematische Übersichtn=2,025 · very large study2025
Einfach gesagt: Further RCTs are needed to verify the influence of lycopene provided within supplements, functional foods, and regular food products on various mental health problems in diverse populations.
Głąbska D, Guzek D, Jílková A, Kołota-Burdzy A, Skolmowska D, Kouřimská L. · Nutrients (2025)
In spite of the fact that all six included studies were RCTs, the comparison between the intervention group and placebo group was made in only four studies, and none of them stated the difference between the compared groups.
A low risk of bias was concluded for three studies (all of them not confirming the influence of lycopene on mental health), and a high risk of bias was found in three studies (one of them not confirming, and two not conclusive).
Conclusions : The evidence gathered within the systematic review of RCTs did not confirm any influence of lycopene on mental health.
18Systematische Übersichtn=108,574 · very large study2025
Balali A, Fathzadeh K, Askari G, Sadeghi O. · Frontiers in nutrition (2025)
High intakes and high levels of lycopene compared to low amounts were, respectively, associated with 5% (Pooled RR: 0.95, 95% CI: 0.92-0.98, I 2 = 26.4%, p = 0.002) and 11% (Pooled RR: 0.89, 95% CI: 0.84-0.95, I 2 = 15.0%, p < 0.001) reduction in overall cancer risk.
Also, each 10 μg/dL increase in blood levels of lycopene was associated with a 5% lower risk of overall cancer.
Moreover, we found a linear inverse association between dietary lycopene intake and prostate cancer risk (Pooled RR 0.99, 95% CI 0.97-1.00, I 2 = 0, p = 0.045).
Einfach gesagt: Furthermore, this review may support the design of future research by critically analyzing existing studies and highlighting inconsistencies and knowledge gaps.
Bajon A et al. · Nutrients (2026)
Among these, carotenoids, particularly lycopene, play a key role.
This review summarizes current knowledge on the nutritional value, composition, and functional properties of tomatoes.
It also addresses the antinutritional aspects of tomato compounds, as well as the influence of agrotechnical, environmental, and technological factors on the content of bioactive compounds.
López-Solís R, Castro-Barquero S, Donat-Vargas C, Corrado M, Arancibia-Riveros C, Martínez-González MÁ, Salas-Salvadó J, Sorlí JV, Serra-Majem L, Fitó M, Pintó X, Fiol M, Lapetra J, Gómez-Gracia E, Toledo E, Ramírez-Sabio JB, Babio N, Estruch R, Ros E, Lamuela-Raventós RM. · BMC medicine (2025)
Cox proportional hazard models were used to estimate hazard ratios (HR) and 95% confidence intervals (CI) across lycopene intake quartiles.
Participants in the highest quartile of lycopene intake had a significantly lower risk of prostate cancer than those in the lowest quartile (HR: 0.46; 95% CI: 0.23-0.95; p-trend = 0.035).
A nonlinear dose-response relationship was observed, with a significant inverse association emerging at intakes above 4.9 mg/day (HR: 0.36; 95% CI: 0.13-0.98).