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Modafinil – Forschung

Überwiegend Mechanismus / Beobachtung

45 begutachtete Studien

Was die Evidenz sagt

Überwiegend Mechanismus / Beobachtung

Die meisten Studien zu Modafinil sind mechanistisch oder beobachtend statt RCTs, die einen klinischen Effekt messen — betrachte die Ergebnisse als vorläufig.

Die meiste Evidenz stammt aus hochwertigen Meta-Analysen und randomisierten Studien, veröffentlicht 1998–2026 mit einer typischen Studiengröße von 283 Teilnehmenden.

Basierend auf 45 Studien · 12 Meta-Analysen · 17 RCTs · 7,148 Teilnehmende insgesamt

Konfidenz

Hohe Konfidenz

Nach Outcome

Cognition & executive function
Überwiegend Mechanismus / Beobachtung16 Studien
Sleepiness & sleep disorders
Überwiegend Mechanismus / Beobachtung14 Studien
Safety profile
Überwiegend Mechanismus / Beobachtung6 Studien
Focus & attentionVerbessert die objektive Wachheit bei Narkolepsie, Schichtarbeitersyndrom und behandelter OSA deutlich; bei gesunden Erwachsenen ist ein moderater, aufgabenabhängiger kognitiver Nutzen am konsistentesten unter anspruchsvollen Bedingungen bzw. bei Schlafentzug · Stunden pro Dosis; Wochen für einen stabilen Nutzen
Überwiegend Mechanismus / Beobachtung3 Studien

Aktives Forschungsgebiet

24 Studien in den letzten 5 Jahren · Neueste Meta-Analyse: 2026

199820122026

1Meta-Analysen=2,000 · very large study2026

Einfach gesagt: The results suggest that reductions in stimulant use may serve as meaningful efficacy signals that could be underestimated when relying solely on stringent outcomes, such as abstinence.

Amin-Esmaeili M, Farokhnia M, Mojtabai R, Leggio L, Johnson RM, Susukida R. · JAMA psychiatry (2026)

Results A total of 2000 participants were included (1134 in cocaine RCTs and 866 in methamphetamine RCTs), of whom 587 (29.4%) were women, with a mean (SD) age of 39.7 (8.6) years.
Overall, 446 participants (31.2%, weighted) achieved reduced use, whereas 184 (13.3%, weighted) achieved abstinence at the trial end point.
In analyses of individual medications, cabergoline showed positive effect sizes (Cohen h, 0.352; 95% CI, 0.115-0.590), indicating significantly higher rates of reduced cocaine use with cabergoline than pooled placebo.

Modafinil – Forschung

Überwiegend Mechanismus / Beobachtung

Evaluating Reduced Use and Abstinence as Outcomes in Pharmacotherapy Trials for Stimulant Use Disorder: A Meta-Analysis of 12 Randomized Controlled Trials

Multiple treatment comparison in narcolepsy: a network meta-analysis.

Psychostimulants for hypersomnia (excessive daytime sleepiness) in myotonic dystrophy.

The Efficacy of Modafinil as a Cognitive Enhancer: A Systematic Review and Meta-Analysis.

Medications for daytime sleepiness in individuals with idiopathic hypersomnia.

How effective are pharmaceuticals for cognitive enhancement in healthy adults? A series of meta-analyses of cognitive performance during acute administration of modafinil, methylphenidate and D-amphetamine.

Efficacy, Acceptability, and Tolerability of Lisdexamfetamine, Mixed Amphetamine Salts, Methylphenidate, and Modafinil in the Treatment of Attention-Deficit Hyperactivity Disorder in Adults: A Systematic Review and Meta-analysis.

Modafinil for people with schizophrenia or related disorders.

Pharmacological interventions for ADHD: a systematic review and dose-effect network meta-analysis

Comparative Efficacy and Safety of Multiple Wake-Promoting Agents for the Treatment of Residual Sleepiness in Obstructive Sleep Apnea Despite Continuous Positive Airway Pressure: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials

The Potential Procognitive Effects of Modafinil in Major Depressive Disorder: A Systematic Review.

Modafinil for poststroke patients: A systematic review.

Amantadine and Modafinil as Neurostimulants During Post-stroke Care: A Systematic Review.

Efficacy and safety of modafinil versus dexamethasone in cancer-related fatigue: a prospective randomized controlled study.

Modafinil treatment modulates functional connectivity in stroke survivors with severe fatigue.

Moral decision making under modafinil: a randomized placebo-controlled double-blind crossover fMRI study.

Modafinil Versus Amphetamine-Dextroamphetamine For Idiopathic Hypersomnia and Narcolepsy Type 2: A Randomized, Blinded, Non-inferiority Trial.

Predicting Modafinil-Treatment Response in Poststroke Fatigue Using Brain Morphometry and Functional Connectivity.

Modafinil Decreased Thalamic Activation in Auditory Emotional Processing: A Randomized Controlled Functional Magnetic Resonance Imaging Study.

Comparative effectiveness of cognitive behavioural therapy, modafinil, and their combination for treating fatigue in multiple sclerosis (COMBO-MS): a randomised, statistician-blinded, parallel-arm trial.