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Phs6.0
Phosphatidylserine – Forschung
Überwiegend Mechanismus / Beobachtung
18 begutachtete Studien
Was die Evidenz sagt
Überwiegend Mechanismus / Beobachtung
Die meisten Studien zu Phosphatidylserine sind mechanistisch oder beobachtend statt RCTs, die einen klinischen Effekt messen — betrachte die Ergebnisse als vorläufig.
Die meiste Evidenz stammt aus hochwertigen Meta-Analysen und randomisierten Studien, veröffentlicht 2008–2026 mit einer typischen Studiengröße von 109 Teilnehmenden.
Basierend auf 18 Studien · 1 Meta-Analyse · 9 RCTs · 2,005 Teilnehmende insgesamt
Konfidenz
Hohe Konfidenz
Was die Studien gefunden haben
1geholfen· 17 weitere ohne bewertete Effektdaten
Nach Outcome
Cognitive functionBessere Gedächtnisleistung, insbesondere bei kognitivem Abbau · 4-12 weeks
Überwiegend Mechanismus / Beobachtung13 Studien
Neuroprotection & brain agingStabilisiert neuronale Membranen und verlangsamt den kognitiven Abbau · 8-12 weeks
Überwiegend Mechanismus / Beobachtung3 Studien
Anxiety & stressReduzierte Cortisol- und Stressreaktion · 2-4 weeks · Abschwächung der Cortisolreaktion auf Stressoren · 1-4 weeks
Überwiegend Mechanismus / Beobachtung3 Studien
Cholesterol & lipids
Zu wenige bewertete Studien2 Studien
Focus & attentionUnterstützt Aufmerksamkeit und Verarbeitungsgeschwindigkeit über die Integrität der Zellmembran · 4-8 weeks
Zu wenige bewertete Studien1 Studie
RecoveryAbgeschwächte Cortisolreaktion auf körperliche Belastung · 2 weeks
Zu wenige bewertete Studien1 Studie
Women's healthKann helfen, PMS-bedingte stimmungsbezogene und kognitive Symptome zu reduzieren · 1-3 cycles
Zu wenige bewertete Studien1 Studie
Therapeutic & clinical
Zu wenige bewertete Studien1 Studie
In Zahlen
Aus 10 Studien mit messbaren Effekten gezogen
Wahrscheinlich echte Effekte
100%
über Studien hinweg
Untersuchte Personen
2,005
typische Studie: 109 Personen
Stärkste Designs
10
1 gepoolt, 9 randomisiert
Zeigte Nutzen
100%
1/1 Studien
Wie lange Studien liefen
1–3 Monate
2
Untersuchte Populationen
Age-related cognitive decline1
Chinese older adults with mild cognitive impairment1
Children with ADHD1
Patients with carpal tunnel syndrome1
Aktives Forschungsgebiet
12 Studien in den letzten 5 Jahren · Neueste Meta-Analyse: 2021
200820172026
1Systematische ÜbersichtCited 11×n=118 · medium study2023
The areas of neurology and psychiatry have shown great advances regarding the deepening of knowledge in prophylaxis and pathophysiology, as well as in the treatment of established diseases.
Nogueira-de-Almeida CA et al. · Central nervous system agents in medicinal chemistry (2023)
According to the GRADE instrument, most studies (>50%) followed a controlled clinical study model and had a good methodological design.
The areas of neurology and psychiatry have shown great advances regarding the deepening of knowledge in prophylaxis and pathophysiology, as well as in the treatment of established diseases.
The recognition of the role of nutrition as an adjunct to these processes is currently growing.
3Cognitive function improvementsRCTCited 5×n=190 · medium study2025
This food supplement containing phosphatidylserine could improve different cognitive functions of MCI patients, especially short-term memory, and increase serum n-3 PUFAs and neurotransmitters levels.
Duan H et al. · Journal of affective disorders (2025)
A total of 190 participants (mean [SD] age, 67.95 [5.62] years; 70 (36.8 %) male and 120 (63.2 %) female) were randomized to the placebo group (n = 95) and intervention group (n = 95).
Compared with placebo group, the intervention group had statistically significant improvements in arithmetic testing (β, 0.688; 95 % CI, 0.103-1.274), the similarity test (β, 1.070; 95 % CI, 0.472-1.667) and short-term memory (β, 0.600; 95 % CI, 0.399-0.800).
And the intervention may improve short-term memory by increasing serum ALA levels (average causal mediation effect = 0.132, 95 % CI, 0.053-0.225) with 19.7 % mediation proportion.
4ADHD symptoms (inattention, hyperactivity-impulsivity)Meta-Analysen=216 · medium study2021
Results of the meta-analysis showed a statistically significant effect of 200-300 mg/day of phosphatidylserine on symptoms of inattention relative to placebo (effect size [ES] 0.36; 95% CI: 0.07 to 0.64; p = 0.01).
Bruton A et al. · Journal of alternative and complementary medicine (2021)
Four studies met the inclusion criteria for the narrative review (n = 344) and three for the meta-analysis (n = 216).
Statistically significant effect of 200-300 mg/day of phosphatidylserine on symptoms of inattention relative to placebo (ES 0.36; 95% CI: 0.07 to 0.64; p = 0.01).
Preliminary evidence suggests phosphatidylserine may be effective for reducing symptoms of inattention in children with ADHD, although the quality of the evidence is low.
Dietary integration could be considered as an option in patients who could not undergo surgery.
D'Orio M et al. · Acta bio-medica : Atenei Parmensis (2023)
Dietary integration could be considered as an option in patients who could not undergo surgery.
Symptoms and pain could improve, but surgery remains the gold standard for recovery of function in mild to moderate CTS.
Further research warranted to confirm findings
6Glycemic factors and hepatic functionRCTCited 160×n=80 · small study2020
In conclusion, the present trial shows that supplementation with a phytosomal preparation of curcumin containing phosphatidylserine and piperine could improve glycemic factors, hepatic function and serum cortisol levels in subjects with overweight and impaired fasting glucose.
Cicero AFG et al. · European journal of nutrition (2020)
After 56-day treatment, the curcumin-treated group experienced a significant improvement in fasting plasma insulin (FPI), HOMA index, waist circumference, blood pressure, triglycerides (TG), HDL-C, liver transaminases, gamma-GT, index of liver steatosis and serum cortisol compared to the baseline.
FPI, TG, liver transaminases, fatty liver index and serum cortisol level also significantly improved compared with the placebo-treated group.
In conclusion, the present trial shows that supplementation with a phytosomal preparation of curcumin containing phosphatidylserine and piperine could improve glycemic factors, hepatic function and serum cortisol levels in subjects with overweight and impaired fasting glucose.
Results substantiate the efficacy of PAS in reducing symptoms of PMS.
Schmidt K et al. · Clinical nutrition ESPEN (2018)
Likely real
For the biomarkers, the salivary cortisol percentage increase of the CAR was significantly less pronounced in the follicular phase of cycle 4 than in the follicular phase of cycle 1 for subjects taking PAS when compared to subjects taking placebo (p = 0.018).
Results substantiate the efficacy of PAS in reducing symptoms of PMS.
In view of the recent inclusion of severe PMS symptoms (PMDD) in the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5), the positive results of this clinical study merits consideration of developing the PAS complex as a botanical drug for treatment of PMDD.
8Memory and cognitive functionsRCTCited 21×n=109 · medium study2022
Results indicated significant benefits of Magtein®PS in improving memory and cognition in healthy Chinese adults.
Zhang C et al. · Nutrients (2022)
Subjects receiving Magtein®PS showed significant improvements over the control group in all five subcategories of "The Clinical Memory Test" as well as the overall memory quotient scores.
The older participants showed more improvement than younger participants.
Results indicated significant benefits of Magtein®PS in improving memory and cognition in healthy Chinese adults.
Understanding these pathways may lead to novel therapeutic approaches targeting erythrocyte redox homeostasis to mitigate thrombotic risk and improve patient outcomes.Thieme.
Borghi S et al. · Seminars in thrombosis and hemostasis (2026)
Despite these insights, the full scope of erythrocyte-mediated redox signaling in thrombotic processes remains incompletely understood.
This review discusses the multifaceted impact of erythrocyte oxidative stress on thrombosis and hemostasis, exploring its implications in cardiovascular diseases, metabolic disorders, and hematological conditions.
Understanding these pathways may lead to novel therapeutic approaches targeting erythrocyte redox homeostasis to mitigate thrombotic risk and improve patient outcomes.Thieme.
Future research should prioritize standardized experimental platforms, harmonized outcome measures, and prospective multicenter clinical studies before RBC-related parameters can be considered for biomarker development and therapeutic targeting.Thieme.
Alamin AA et al. · Seminars in thrombosis and hemostasis (2026)
Overall, these findings support a more integrated cellular framework of thrombosis, in which RBCs may modulate platelet behavior, coagulation dynamics, and thrombus architecture.
However, because most of the included studies were experimental or mechanistic, clinical translation remains limited.
Future research should prioritize standardized experimental platforms, harmonized outcome measures, and prospective multicenter clinical studies before RBC-related parameters can be considered for biomarker development and therapeutic targeting.Thieme.
This systematic-review examined the effects of Phosphatidylserine.
Henn D et al. · Autophagy (2025)
To maintain lysosome integrity and functionality, cells have evolved multiple quality control pathways corresponding to different types of stress and damage.
These can be divided into five levels: regulation, reformation, repair, removal, and replacement.
The different levels of lysosome quality control often work together to maintain the integrity of the lysosomal network.
6 months of Soy-PS supplementation could improve the memory functions of the elderly with memory complaints.
Kato-Kataoka A et al. · Journal of Clinical Biochemistry and Nutrition (2010)
78 elderly people with mild cognitive impairment (50-69 years old) were randomly allocated to take Soy-PS (100 mg, 300 mg/day) or placebo for 6 months.
In subjects with relatively low score at baseline, the memory scores in PS-treated groups were significantly increased against the baseline, while placebo remained unchanged.
Memory improvements were mostly attributed to the increase in delayed verbal recall; Soy-PS was well tolerated.
In the future, supplementation with phytosterols and phospholipids may be considered for improving blood lipid profiles in individuals with borderline hyperlipidemia, thereby preventing or delaying the progression to overt hyperlipidemia and cardiovascular diseases.
Li L et al. · Food & function (2026)
Spürbar Nutzen
← SchlechterKein EffektBesser →
Likely real
After 60 days of intervention, the levels of total cholesterol (TC) and apolipoprotein B (ApoB) in the combined PSs and PLs group decreased by 7.8% and 6.4% (P < 0.001), respectively, relative to the baseline.
In the PSs-only group, the level of total cholesterol (TC) was significantly reduced by 6.2% (P < 0.001).
Nevertheless, in the PSs and PLs group, low-density lipoprotein cholesterol (LDL-C) was significantly reduced by 7.7% compared with the baseline only at 30 days of intervention (P = 0.017).