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Pinealon – Forschung

Überwiegend Mechanismus / Beobachtung

7 begutachtete Studien

Was die Evidenz sagt

Überwiegend Mechanismus / Beobachtung

Die meisten Studien zu Pinealon sind mechanistisch oder beobachtend statt RCTs, die einen klinischen Effekt messen — betrachte die Ergebnisse als vorläufig.

Die meiste Evidenz stammt aus gemischt-qualitativen Studien, veröffentlicht 2012–2024.

Basierend auf 7 Studien

Konfidenz

Geringe Konfidenz

Nach Outcome

Neuroprotection & brain agingEin kurzes Peptid mit neuroprotektiven Signalen in Zellen und Tieren unter hypoxischem/oxidativem Stress; die Evidenz ist dünn, von geringer Qualität und stammt von einer einzigen Arbeitsgruppe, mit uneinheitlichen (u. a. prooxidativen) Befunden. · Nicht belegt (keine belastbaren Humandaten)
Überwiegend Mechanismus / Beobachtung3 Studien
Longevity & agingWird zur Verbesserung des 'biologischen Alters' auf Basis schwacher Humanberichte und einer postulierten epigenetischen Genregulation beworben; die langfristige Sicherheit beim Menschen ist weitgehend unbekannt. · Nicht belegt
Überwiegend Mechanismus / Beobachtung3 Studien
Cognitive function
Zu wenige bewertete Studien2 Studien

Stetige Forschung

1 Studie in den letzten 5 Jahren

201220182024

1In vitro2014

Einfach gesagt: Peptides Glu-Asp-Arg and Lys-Glu-Asp stimulate serotonin expression in aging cultures of brain cortex cells.

Khavinson VKh, Lin'kova NS, Tarnovskaya SI, Umnov RS, Elashkina EV, Durnova AO. · Bull Exp Biol Med (2014)

In-vitro study reporting that Glu-Asp-Arg (EDR) stimulates serotonin expression in aging brain-cortex cell cultures
Used molecular docking to propose EDR regulates the 5-tryptophan-hydroxylase gene (the enzyme in serotonin synthesis)
Identified a complementary CCTGCC nucleotide sequence as the proposed binding target

Quelle ansehen

2Übersicht2020

Einfach gesagt: The EDR peptide (Glu-Asp-Arg) has been previously established to possess neuroprotective properties.

Khavinson V, Linkova N, Kozhevnikova E, Trofimova S. · Molecules (2020)

Review from the originating group laying out the proposed mechanism of the EDR (Glu-Asp-Arg) peptide in neuroprotection
Proposes EDR enters cells and binds histones/RNA, altering the MAPK/ERK pathway and synthesis of proapoptotic (caspase-3, p53) and antioxidant (SOD2, GPX1) proteins
States EDR interferes with dendritic-spine elimination in Alzheimer's/Huntington's neuronal cultures and 'improves memory issues in elderly patients'

Quelle ansehen

3In vitro2024

Einfach gesagt: EDR peptide reduces oxidative DNA damage in induced neurons derived from elderly donor fibroblasts.

Kraskovskaya N, Linkova N, Sakhenberg E, Krieger D, Polyakova V, Medvedev D, Krasichkov A, Khotin M, Ryzhak G. · Int J Mol Sci (2024)

In-vitro human-cell model: aged dermal fibroblasts from elderly donors transdifferentiated into induced cortical neurons
EDR (Glu-Asp-Arg) and related peptides promoted arborisation of the dendritic tree, increasing the number and total length of dendrites
EDR specifically reduced oxidative DNA damage in induced neurons from elderly donors

Quelle ansehen

4Open-Label2012

Einfach gesagt: Workers of locomotive brigades used preparation during two weeks (1 capsule containing 100 mkg of Pinealon 2 times a day). Pinealon application has improved parameters of biological age and indicators determining the effectiveness of adaptive reactions.

Nazimko VA, Morgul' EV, Petrova OA, Sheĭkhova RG, Kozina LS, Savenko MA, Lysenko DS. · Adv Gerontol (2012)

Small, open, uncontrolled human report in locomotive-brigade workers exposed to occupational stress
Used oral Pinealon capsules of 100 mcg twice daily for two weeks — the source of the only published human dosing reference
Claimed improved biological-age parameters and adaptive-reaction indicators

5Open-Label2015

Einfach gesagt: The preparations of "Pinealon" and "Vesugen" have had the significant anabolic effect.

Meshchaninov VN, Tkachenko EL, Zharkov SV, Gavrilov IV, Katyreva IuE. · Adv Gerontol (2015)

Small human study (32 people, aged 41-83) with polymorbidity and organic brain syndrome in remission, using Pinealon and Vesugen
Reported anabolic effects and slowed biological-age indicators, with Vesugen showing a more visible effect than Pinealon
Crucially also found prooxidant activity by chemiluminescence and a significant decrease in CD34+ haematopoietic markers — flagged as needing future study

6Tierstudie2014

Einfach gesagt: in hypoxia of brain conditions Pinealon forwards the increase of the neurogenesis and the decrease neuroinflammatory reactions to a reference level.

Mendzheritskiĭ AM, Karantysh GV, Ryzhak GA, Dem'ianenko SV. · Adv Gerontol (2014)

Animal study: aged rats under acute hypoxic hypoxia, examining caspase-3 activity in brain and IL-6 / TNF in serum
Pinealon (Glu-Asp-Arg) was associated with increased neurogenesis and a decrease in neuroinflammatory reactions toward reference levels under brain hypoxia
Compared against Cortexin, which reduced programmed cell death but kept IL-6 elevated

7Open-Label2016

Einfach gesagt: The most pronounced positive impact on indicators of biological age were detected during the combined use of these two Oligopeptide complexes.

Myakotnykh VS, Torgashov MN, Egorin KV, Meshchaninov VN, Gavrilov VI, Borovkova TA, Zvezdina EM, Verzhbitskaya TY, Tkachenko EL. · Adv Gerontol (2016)

Human study of 110 people across age groups comparing several geroprotective methods, including the oligopeptides Vezugen and Pinealon (Glu-Asp-Arg)
The combined use of the two peptides gave the most pronounced positive impact on biological-age indicators
The oligopeptide preparations were rated among the safest of the methods compared on biochemical, immunological, and clinical parameters

In der Forschungsbibliothek ansehen

Pinealon – Forschung

Überwiegend Mechanismus / Beobachtung

Short peptides stimulate serotonin expression in cells of brain cortex.

EDR Peptide: Possible Mechanism of Gene Expression and Protein Synthesis Regulation Involved in the Pathogenesis of Alzheimer's Disease.

Short Peptides Protect Fibroblast-Derived Induced Neurons from Age-Related Changes.

Analysis of some parameters of biological age and adaptation possibilities of workers of locomotive brigades.

Effect of synthetic peptides on aging of patients with chronic polymorbidity and organic brain syndrome of the central nervous system in remission.

Regulation of content of cytokines in blood serum and of caspase-3 activity in brains of old rats in model of sharp hypoxic hypoxia with Cortexin and Pinealon.

Comparative analysis of different methods of geroprotective.