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Pr5.5
Propolis – Forschung
Hilft wahrscheinlich
171 begutachtete Studien
Was die Evidenz sagt
Hilft wahrscheinlich
Propolis scheint in 9 von 9 Studien mit messbaren Effekten zu helfen — die Evidenz tendiert klar ins Positive.
Die meiste Evidenz stammt aus hochwertigen Meta-Analysen und randomisierten Studien, veröffentlicht 1979–2026 mit einer typischen Studiengröße von 194 Teilnehmenden.
Basierend auf 171 Studien · 31 Meta-Analysen · 107 RCTs · 12,153 Teilnehmende insgesamt
Immune supportVerbesserte Immunfunktion und Infektionsresistenz · 2-4 Wochen
Überwiegend Mechanismus / Beobachtung19 Studien
Therapeutic & clinical
Überwiegend Mechanismus / Beobachtung16 Studien
Cholesterol & lipids
Überwiegend Mechanismus / Beobachtung11 Studien
Wound & ulcer healing
Überwiegend Mechanismus / Beobachtung9 Studien
Liver health
Überwiegend Mechanismus / Beobachtung7 Studien
Safety profile
Überwiegend Mechanismus / Beobachtung4 Studien
Cold sores & HSV
Überwiegend Mechanismus / Beobachtung3 Studien
Depression & mood
Zu wenige bewertete Studien2 Studien
Heart & blood pressure
Zu wenige bewertete Studien2 Studien
Skin health
Zu wenige bewertete Studien1 Studie
In Zahlen
Aus 32 Studien mit messbaren Effekten gezogen
Wahrscheinlich echte Effekte
100%
über Studien hinweg
Untersuchte Personen
12k
typische Studie: 194 Personen
Stärkste Designs
138
31 gepoolt, 107 randomisiert
Zeigte Nutzen
100%
9/9 Studien
Wie lange Studien liefen
1–3 Monate
2
Untersuchte Populationen
Adults3
COVID-19 patients2
Type 2 diabetes patients with periodontitis1
Various conditions with inflammation1
Aktives Forschungsgebiet
117 Studien in den letzten 5 Jahren · Neueste Meta-Analyse: 2025
197920022026
1Meta-AnalyseCited 1×n=3,544 · very large study2025
This meta-analysis examined the effects of Propolis.
Norouzzadeh M et al. · Nutrition & diabetes (2025)
Propolis demonstrated reductions in anthropometric measures and improvements in lipid profile, glycemic control, liver enzymes, and inflammation and oxidative stress markers.
While long-term or high-dose honey consumption in individuals with health concerns warrants caution, RJ and propolis demonstrated dose-dependent benefits for cardiometabolic health with proper certainty.
Future research should focus on population-specific characteristics and optimized dosages.
2IL-6 reductionMeta-AnalyseCited 2×n=1,139 · large study2024
The propolis supplementation significantly reduced IL-6 (WMD = -2.48; 95 % CI: -4.62, -0.34; P = 0.023) and TNF-α (WMD = -0.86; 95 % CI: -1.45, -0.26; P = 0.005) compared with control groups.
Zhong-Yong L et al. · Prostaglandins & other lipid mediators (2024)
Spürbar Nutzen
← SchlechterKein EffektBesser →
Likely real
The propolis supplementation significantly reduced IL-6 (WMD = -2.48; 95 % CI: -4.62, -0.34; P = 0.023) and TNF-α (WMD = -0.86; 95 % CI: -1.45, -0.26; P = 0.005) compared with control groups.
Although the CRP concentration was not reduced (WMD = 0.01; 95 % CI: -0.03, 0.05, P = 0.646), a significant reduction in CRP levels was revealed in supplementation durations ≥ 10 weeks.
These results suggest that propolis has a beneficial effect on TNF-α and IL-6 levels and may be an effective adjunctive therapy for diseases where inflammation is a key factor in the etiology.
Antioxidants, particularly melatonin and propolis, enhance periodontal and glycemic outcomes in T2D-periodontitis patients.
Abdulla SA et al. · Clinical and experimental dental research (2025)
Sehr groß Nutzen
← SchlechterKein EffektBesser →
Adjunctive antioxidants significantly improved CAL (melatonin: SMD -2.28, 95% CI -3.01 to -1.56; propolis: SMD -3.83, -4.79 to -2.87) and PD (melatonin: SMD -2.40, -3.14 to -1.66; propolis: SMD -1.78, -2.44 to -1.11).
Melatonin and propolis also reduced HbA1c (melatonin: SMD -2.28; propolis: SMD -3.83).
Antioxidants, particularly melatonin and propolis, enhance periodontal and glycemic outcomes in T2D-periodontitis patients.
18Anti-inflammatory mechanismsSystematische ÜbersichtCited 84×n=166 · medium study2022
Propolis also reduces the migration of immune cells such as macrophages and neutrophils, possibly by downregulating the chemokines CXCL9 and CXCL10.
Zulhendri F et al. · Molecules (Basel, Switzerland) (2022)
Several key themes related to the anti-inflammatory properties of propolis were subsequently identified, namely in relation to cancers, oral health, metabolic syndrome, organ toxicity and inflammation, immune system, wound healing, and pathogenic infections.
Based on the latest experimental evidence, propolis is demonstrated to possess various mechanisms of action in modulating inflammation towards the regulatory balance and anti-inflammatory environment.
In general, we summarize that propolis acts as an anti-inflammatory substance by inhibiting and downregulating TLR4, MyD88, IRAK4, TRIF, NLRP inflammasomes, NF-κB, and their associated pro-inflammatory cytokines such as IL-1β, IL-6, IFN-γ, and TNF-α.
19Mucositis severity scoresMeta-AnalyseCited 20×n=199 · medium study2022
Though oral and topical antioxidants significantly improved mucositis severity scores in HNC patients receiving radiotherapy with/without chemotherapy in individual studies, the quality of the evidence was low due to the small number of studies and unclear/high-risk bias.
Raza A et al. · Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer (2022)
Likely real
Included studies showed a statistically significant improvement in mucositis severity score for all antioxidants except melatonin.
Patients receiving vitamin E were 60% less likely to develop severe mucositis grade 2 or higher than those receiving placebo in one study (P = 0.040).
Patients receiving zinc were 95% less likely to develop severe mucositis (grades 3-4) in one study compared to placebo (P = 0.031).
20CKD progression prevention and treatmentSystematische ÜbersichtCited 7×2024
These results suggest that bioactive compounds of plant-based foods and medicinal plants have promising effects in terms of preventing or treating CKD progression and appear to improve inflammation and antioxidant capacity and support cardiovascular benefits and renoprotective effects; however, it is recommended that further studies be carried out.