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Pr5.5
Propolis – Forschung
Hilft wahrscheinlich
157 begutachtete Studien
Was die Evidenz sagt
Hilft wahrscheinlich
Propolis scheint in 7 von 7 Studien mit messbaren Effekten zu helfen — die Evidenz tendiert klar ins Positive.
Die meiste Evidenz stammt aus hochwertigen Meta-Analysen und randomisierten Studien, veröffentlicht 1979–2026 mit einer typischen Studiengröße von 373 Teilnehmenden.
Basierend auf 157 Studien · 23 Meta-Analysen · 104 RCTs · 9,942 Teilnehmende insgesamt
Immune supportVerbesserte Immunfunktion und Infektionsresistenz · 2-4 Wochen
Überwiegend Mechanismus / Beobachtung16 Studien
Therapeutic & clinical
Überwiegend Mechanismus / Beobachtung13 Studien
Cholesterol & lipids
Überwiegend Mechanismus / Beobachtung10 Studien
Wound & ulcer healing
Überwiegend Mechanismus / Beobachtung6 Studien
Liver health
Überwiegend Mechanismus / Beobachtung5 Studien
Safety profile
Überwiegend Mechanismus / Beobachtung4 Studien
Heart & blood pressure
Überwiegend Mechanismus / Beobachtung3 Studien
Cold sores & HSV
Zu wenige bewertete Studien2 Studien
Depression & mood
Zu wenige bewertete Studien1 Studie
Skin health
Zu wenige bewertete Studien1 Studie
In Zahlen
Aus 27 Studien mit messbaren Effekten gezogen
Wahrscheinlich echte Effekte
100%
über Studien hinweg
Untersuchte Personen
9,942
typische Studie: 373 Personen
Stärkste Designs
127
23 gepoolt, 104 randomisiert
Zeigte Nutzen
100%
7/7 Studien
Wie lange Studien liefen
1–3 Monate
1
Untersuchte Populationen
Adults3
COVID-19 patients2
Head and neck cancer patients1
Type 2 diabetes patients with periodontitis1
Aktives Forschungsgebiet
108 Studien in den letzten 5 Jahren · Neueste Meta-Analyse: 2026
197920022026
1IL-6 reductionMeta-Analysen=1,139 · large study2024
Einfach gesagt: The propolis supplementation significantly reduced IL-6 (WMD = -2.48; 95 % CI: -4.62, -0.34; P = 0.023) and TNF-α (WMD = -0.86; 95 % CI: -1.45, -0.26; P = 0.005) compared with control groups.
Zhong-Yong L et al. · Prostaglandins & other lipid mediators (2024)
Spürbar Nutzen
← SchlechterKein EffektBesser →
Likely real
The propolis supplementation significantly reduced IL-6 (WMD = -2.48; 95 % CI: -4.62, -0.34; P = 0.023) and TNF-α (WMD = -0.86; 95 % CI: -1.45, -0.26; P = 0.005) compared with control groups.
Although the CRP concentration was not reduced (WMD = 0.01; 95 % CI: -0.03, 0.05, P = 0.646), a significant reduction in CRP levels was revealed in supplementation durations ≥ 10 weeks.
These results suggest that propolis has a beneficial effect on TNF-α and IL-6 levels and may be an effective adjunctive therapy for diseases where inflammation is a key factor in the etiology.
9Mucositis severity scoresMeta-Analysen=199 · medium study2022
Einfach gesagt: Though oral and topical antioxidants significantly improved mucositis severity scores in HNC patients receiving radiotherapy with/without chemotherapy in individual studies, the quality of the evidence was low due to the small number of studies and unclear/high-risk bias.
Raza A et al. · Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer (2022)
Likely real
Included studies showed a statistically significant improvement in mucositis severity score for all antioxidants except melatonin.
Patients receiving vitamin E were 60% less likely to develop severe mucositis grade 2 or higher than those receiving placebo in one study (P = 0.040).
Patients receiving zinc were 95% less likely to develop severe mucositis (grades 3-4) in one study compared to placebo (P = 0.031).
Einfach gesagt: Antioxidants, particularly melatonin and propolis, enhance periodontal and glycemic outcomes in T2D-periodontitis patients.
Abdulla SA et al. · Clinical and experimental dental research (2025)
Sehr groß Nutzen
← SchlechterKein EffektBesser →
Adjunctive antioxidants significantly improved CAL (melatonin: SMD -2.28, 95% CI -3.01 to -1.56; propolis: SMD -3.83, -4.79 to -2.87) and PD (melatonin: SMD -2.40, -3.14 to -1.66; propolis: SMD -1.78, -2.44 to -1.11).
Melatonin and propolis also reduced HbA1c (melatonin: SMD -2.28; propolis: SMD -3.83).
Antioxidants, particularly melatonin and propolis, enhance periodontal and glycemic outcomes in T2D-periodontitis patients.
Einfach gesagt: These results suggest that bioactive compounds of plant-based foods and medicinal plants have promising effects in terms of preventing or treating CKD progression and appear to improve inflammation and antioxidant capacity and support cardiovascular benefits and renoprotective effects; however, it is recommended that further studies be carried out.
14Fasting plasma glucose reductionMeta-Analysen=373 · medium study2019
Einfach gesagt: This systematic review and meta-analysis suggested that propolis supplementation may be effective in controlling glycemic levels for T2DM patients.
Karimian J et al. · Phytotherapy research : PTR (2019)
Spürbar Nutzen
← SchlechterKein EffektBesser →
The results of the meta-analysis revealed significant reductions in fasting plasma glucose (-13.51 mg/dl; 95% CI [-24.98, -2.04]) and hemoglobin A1C (-0.52%; 95% CI [-0.94, -0.10]) concentrations following propolis supplementation.
However, no significant lowering effect was observed in fasting insulin levels (-0.53 pmol/L; 95% CI [-1.69, 0.63]) or homeostasis model assessment of insulin resistance (-0.543; 95% CI [-1.72, 0.64]).
This systematic review and meta-analysis suggested that propolis supplementation may be effective in controlling glycemic levels for T2DM patients.
Einfach gesagt: Treatment with propolis improves general health and facilitates the activation of the immune system against coronavirus.
Sales-Peres SHC et al. · Brazilian oral research (2023)
The meta-analysis showed favorable results with the use of propolis on probing depth (95%CI: 0.92; p < 0.001), clinical attachment level (95%CI: 1.48; p < 0.001), gingival index (95%CI: 0.14; p = 0.03), plaque index (95%CI: 0.11; p = 0.23), and blending on probing (95%CI: 0.39; p < 0.001).
The antibacterial activity of propolis could be mediated through its direct action on microorganisms or the stimulation of the immune system, activating natural defenses.
Thus, propolis inhibits the replication of SARS-CoV-2 as well as its bacterial activity.
Einfach gesagt: Although there are a number of promising indications, in view of the limited number and quality of studies and the variation in results among studies, this review highlights the need for additional well-designed trials to draw conclusions that are more robust.
Hwu YJ et al. · The journal of nursing research : JNR (2014)
The result of the meta-analysis indicated that, although propolis had an effect on reducing dental plaque, this effect was not statistically significant.
The results were not statistically significant for oral infection or stomatitis.
Although there are a number of promising indications, in view of the limited number and quality of studies and the variation in results among studies, this review highlights the need for additional well-designed trials to draw conclusions that are more robust.