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Sam7.0
SAMe – Forschung
Gemischte Evidenz
86 begutachtete Studien
Was die Evidenz sagt
Überwiegend Mechanismus / Beobachtung
Die meisten Studien zu SAMe sind mechanistisch oder beobachtend statt RCTs, die einen klinischen Effekt messen — betrachte die Ergebnisse als vorläufig.
Die meiste Evidenz stammt aus hochwertigen Meta-Analysen und randomisierten Studien, veröffentlicht 1984–2026 mit einer typischen Studiengröße von 676 Teilnehmenden.
Basierend auf 86 Studien · 12 Meta-Analysen · 60 RCTs · 3,367 Teilnehmende insgesamt
Konfidenz
Hohe Konfidenz
Was die Studien gefunden haben
1geholfen1unklar· 84 weitere ohne bewertete Effektdaten
Nach Outcome
Depression & moodSignificant improvement in depressive symptoms · 2-6 weeks
Überwiegend Mechanismus / Beobachtung74 Studien
Therapeutic & clinical
Überwiegend Mechanismus / Beobachtung26 Studien
Liver health
Überwiegend Mechanismus / Beobachtung22 Studien
Women's health
Überwiegend Mechanismus / Beobachtung14 Studien
Joint pain & arthritisComparable to NSAIDs for osteoarthritis pain in clinical trials · 4-8 weeks
Überwiegend Mechanismus / Beobachtung11 Studien
Cognitive function
Überwiegend Mechanismus / Beobachtung3 Studien
Neuroprotection & brain aging
Überwiegend Mechanismus / Beobachtung3 Studien
Energy & fatigue
Zu wenige bewertete Studien2 Studien
Heart & blood pressure
Zu wenige bewertete Studien1 Studie
Safety profile
Zu wenige bewertete Studien1 Studie
In Zahlen
Aus 9 Studien mit messbaren Effekten gezogen
Untersuchte Personen
3,367
typische Studie: 676 Personen
Stärkste Designs
72
12 gepoolt, 60 randomisiert
Zeigte Nutzen
50%
1/2 Studien
Wie lange Studien liefen
1–3 Monate
1
Untersuchte Populationen
Patients with mild depression1
Patients with depression1
Males with arousal and erectile dysfunction1
Mammals during starvation1
Stetige Forschung
16 Studien in den letzten 5 Jahren · Neueste Meta-Analyse: 2025
198420052026
1Response ratesMeta-Analysen=1,049 · large study2025
Einfach gesagt: This review demonstrates that certain supplements, such as eicosapentaenoic acids and Rhodiola rosea, are therapeutic options for mild depression.
Urata M et al. · Neuropsychopharmacology reports (2025)
Kein klarer Effekt
← SchlechterKein EffektBesser →
A meta-analysis found no significant difference in response rates between the two treatments (risk ratio [RR] = 0.96, 95% CI: 0.78-1.18) or dropout rates (RR = 1.08, 95% CI: 0.62-1.88).
Eicosapentaenoic acid and Rhodiola rosea demonstrated significant improvements in depressive symptoms compared to placebo.
Conversely, S-adenosylmethionine did not produce significant improvements relative to placebo.
Einfach gesagt: Moderate-certainty evidence suggests that SAMe monotherapy may offer a moderate therapeutic benefit in alleviating depressive symptoms.
Limveeraprajak N et al. · Progress in neuro-psychopharmacology & biological psychiatry (2024)
Moderate-certainty evidence suggests that SAMe monotherapy may offer a moderate therapeutic benefit in alleviating depressive symptoms.
Considering its favorable acceptability profile, SAMe monotherapy should be considered as a treatment option for patients with depression.
However, uncertainties regarding its efficacy as an adjunct to AD and its comparative efficacy with ADs remain unresolved.
The results of SAMe versus placebo as a monotherapy, SAMe versus imipramine or escitalopram as a monotherapy, and SAMe versus placebo as an adjunctive therapy, showed no significant difference in depression with SAMe compared to the comparison treatment.
Conclusions SAMe may provide relief of depression symptoms similar to imipramine or escitalopram.
However, the results of the comparisons should be interpreted with caution due to the small number of studies and the large range of SAMe doses that were used in the included trials.
Einfach gesagt: Appropriate levels of these micronutrients should then be monitored at all stages of development for a healthier brain.
Bekdash RA · International journal of molecular sciences (2023)
Studies in human and animal models have indicated the importance of the optimal levels of methyl donors on brain health and behavior across the lifespan.
Imbalances in the levels of these micronutrients during critical periods of brain development have been linked to epigenetic alterations in the expression of genes that regulate normal brain function.
We present studies that support the link between imbalances in the levels of methyl donors, epigenetic alterations, and stress-related disorders.
Einfach gesagt: The food supplement showed a significant decrease of PHQ-9 and HAM-D scores resulting in reduced SD and MDD symptoms as compared to placebo.
Ullah H et al. · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie (2022)
The food supplement showed a significant decrease of PHQ-9 and HAM-D scores resulting in reduced SD and MDD symptoms as compared to placebo.