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Sbk4.5
Sea Buckthorn – Forschung
Überwiegend Mechanismus / Beobachtung
18 begutachtete Studien
Was die Evidenz sagt
Überwiegend Mechanismus / Beobachtung
Die meisten Studien zu Sea Buckthorn sind mechanistisch oder beobachtend statt RCTs, die einen klinischen Effekt messen — betrachte die Ergebnisse als vorläufig.
Die meiste Evidenz stammt aus hochwertigen Meta-Analysen und randomisierten Studien, veröffentlicht 2010–2026 mit einer typischen Studiengröße von 100 Teilnehmenden.
Basierend auf 18 Studien · 1 Meta-Analyse · 5 RCTs
Konfidenz
Mittlere Konfidenz
Nach Outcome
Skin healthOmega-7-Öl kann die Hautfeuchtigkeit verbessern und Trockenheit reduzieren · 12 weeks · Unterstützt die Integrität von Haut/Schleimhaut (Omega-7); Nutzen bei vaginaler Atrophie in einer RCT · 1-3 months
Überwiegend Mechanismus / Beobachtung3 Studien
Glucose & metabolic
Überwiegend Mechanismus / Beobachtung3 Studien
Vision & eye healthReduzierte Symptome des trockenen Auges und verringerte Tränenfilm-Osmolarität in RCTs · 1-3 months
Zu wenige bewertete Studien2 Studien
Women's health
Zu wenige bewertete Studien1 Studie
Cholesterol & lipidsVerbessert die Blutfettwerte — jedoch nur bei Personen mit bestehender Dyslipidämie · 8-12 weeks
Zu wenige bewertete Studien1 Studie
Safety profile
Zu wenige bewertete Studien1 Studie
Aktives Forschungsgebiet
13 Studien in den letzten 5 Jahren · Neueste Meta-Analyse: 2022
201020182026
1Systematische Übersicht2026
Finally, the review identifies persistent challenges including phytochemical standardization and the translational gap between preclinical and clinical research, and proposes future research directions focused on rigorous clinical trials, mechanistic studies and sustainable exploitation within a circular bioeconomy framework.
Liu M, Yu T, Nurlan U, Wu Z, Zhao J. · Frontiers in pharmacology (2026)
The work then systematically outlines the plant's diverse modern utilizations in nutraceuticals, cosmeceuticals, pharmaceuticals, and environmental remediation.
A thorough organ-specific analysis of its phytochemical architecture that identifies key bioactive constituents in berries, seeds and leaves links to demonstrated pharmacological effects, including hepatoprotective, anti-inflammatory, cardioprotective and neuroprotective activities.
A critical discussion on the potential interference of Pan-Assay Interference Compounds (PAINS) is included to provide a necessary caveat for interpreting bioactivity data.
Including studies on bioavailability and pharmacodynamics could further strengthen the scientific evidence supporting the specific phytochemicals in sea buckthorn and their mechanistic interactions.
Javaid N, Amjad A, Weiskirchen R, Abbas A, Zafar S, Shah M, Javed MS, Afzal K, Zafar U, Israr M. · Foods (Basel, Switzerland) (2026)
Furthermore, its potential against microbial growth, including S. aureus , S. epidermidis , S. intermedius , and S. pyogenes , among others, not only expands its applications in the pharmaceutical industry but also attracts researchers to incorporate it into food products.
This could lead to the discovery of plant-based therapeutic products without significant adverse effects.
However, further exploration of each component's potential side effects is necessary to support the commercialization of formulated products in either the pharmaceutical or food industries, ensuring the highest safety standards for consumers.
Conclusions : These findings suggest that H. rhamnoides fruit extract is a safe and effective option for managing CIC, offering an alternative to other plant extracts with laxative effects.
Morone MV, Spadarella G, Di Minno A, Cordara M, Cerqua A, De Lellis LF, Buccato DG, Baldi A, Piccinocchi R, Ullah H, Piccinocchi G, Xiao X, Sacchi R, Daglia M. · Nutrients (2026)
Background/Objectives : Chronic idiopathic constipation (CIC) is a common gastrointestinal disorder with a global prevalence of about 14%, common in women and elderly population.
H. rhamnoides fruit extract significantly improved SCBM frequency (from 1.5 to 2.6 per week; p < 0.001) and normalized stool consistency (mean BSFS score from 1.4 to 3.5; p < 0.001), compared to no change in the placebo group.
Significant reductions in bloating, abdominal pain, and heaviness were observed, while flatulence showed no between-group significant difference.
Further research, including high-quality in vitro and animal model studies, as well as large-scale clinical trials, is needed to confirm such a putative positive effect and to identify more efficient therapies against various diabetic complications, including DBD.
Biro R, Omelka R, Sarocka A, Penzes N, Kovacova V, Mondockova V, Martiniakova M. · Pharmaceutical biology (2025)
Results and conclusions SB and flavonoids mentioned above exert hypoglycemic and anti-inflammatory properties, attenuate IR, inhibit AGEs formation, thereby positively affecting the main DBD-related mechanisms.
The direct effect of SB on DBD has not been investigated yet, but the beneficial impact of quercetin on DBD has been revealed.
Therefore, it can be assumed that SB could favorably influence DBD, as its great potential to treat other bone-related diseases (osteoporosis, rheumatoid arthritis) has been reported.
However, further research is needed to emphasize the importance of human trials and to explore the intricate relationship between SBP and gut microbiota, as these insights are crucial for understanding the mechanisms underlying SBP's benefits for the gastrointestinal tract (GIT).
Yuan H, Huang H, Du Y, Zhao J, Yu S, Lin Y, Chen Y, Shan C, Zhao Y, Belwal T, Fu X. · Food chemistry (2025)
Polyphenols influence nutrient absorption and metabolism by regulating the intestinal flora, thereby enhancing bioavailability, protecting the gastrointestinal tract, and altering nutrient structures.
Additionally, polyphenols exhibit anti-inflammatory and immunomodulatory effects, promoting intestinal health.
The interaction between polyphenols and intestinal flora plays a significant role in gastrointestinal health, supporting the composition and diversity of the gut microbiota.
The aim is to promote the effective utilization of herbal medicine and provide insights and references for the development of novel therapeutics for DCM.
Zhang Q, Zhang J, Ouyang Y, Liu H, Xie C, Fu X. · Frontiers in pharmacology (2025)
Sea buckthorn flavonoids and their derivatives represent a promising class of natural compounds for the treatment of DCM.
This article provides a brief overview of the pharmacological effects of sea buckthorn flavonoids and their derivatives and systematically reviews their mechanisms in improving DCM.
The aim is to promote the effective utilization of herbal medicine and provide insights and references for the development of novel therapeutics for DCM.
The findings underscore the untapped potential of natural products in barrier protection and regenerative medicine, paving the way for future clinical applications.
Song X, Sun X, Yuan H, Tang Y, Zheng F. · Frontiers in pharmacology (2025)
These mechanisms not only reinforce barrier function but also mitigate inflammation and accelerate healing.
This review synthesizes current evidence on sea buckthorn's multi-target anti-inflammatory actions and its implications for skin and mucosal health through a unique lens of the inflammatory cascade.
By elucidating its molecular and cellular effects across distinct stages of inflammation, we provide a foundation for translating these insights into novel dermatological and mucosal therapeutics.
This article provides insight into the benefits of sea buckthorn, encouraging academic research in this area and the expansion of sea buckthorn-based applications for digestive diseases.
Dong W, Tang Y, Qiao J, Dong Z, Cheng J. · Frontiers in pharmacology (2025)
In both in vitro and in vivo experiments, ranging from cell lines to animal models and human patients, sea buckthorn has shown beneficial effects on symptoms associated with digestive disease.
This study reviews the main bioactive metabolites of sea buckthorn and discusses their pharmacological effects and mechanisms in treating digestive diseases.
In particular, we highlight bioactive metabolites isolated from sea buckthorn, their effects on inflammation, cancer, anti- Helicobacter pylori , radiation, and gut microbiota, and their molecular mechanisms of action in clinical applications.
Particularly, the potential value of sea buckthorn and the novel technologies applied in previous studies are also discussed to improve its use for human health.
Zhu P, Ren Y, Wei C, Luo J, Wu D, Ye X, Donlao N, Tian J. · Food chemistry (2025)
The main bioactive compounds extracted and characterized in sea buckthorn are polyphenols, carotenoids, and functional lipids, which could provide health benefits by scavenging free radicals, regulating enzyme activities, and modulating signaling pathways, etc.
Although there are many studies focused on the values of sea buckthorn, a comprehensive review on its chemical composition, functional mechanism and food application are still lacking.
Thus, this paper aims to review the bioactive compounds in sea buckthorn, their underlying mechanisms for health benefits, as well as the applications in health food development.
The research progress and application prospect of sea buckthorn and its active components in anti-tumor types, mechanism of action, liver protection, anti-radiation and toxicology were reviewed, providing theoretical basis for the development of sea buckthorn products in the field of anti-tumor research and clinical application.
Xu D, Yuan L, Meng F, Lu D, Che M, Yang Y, Liu W, Nan Y. · Frontiers in nutrition (2024)
Sea buckthorn ( Hippophae Fructus ), as a homologous species of medicine and food, is widely used by Mongolians and Tibetans for its anti-tumor, antioxidant and liver-protecting properties.
In this review, the excellent anti-tumor effect of sea buckthorn was first found through network pharmacology, and its active components such as isorhamnetin, quercetin, gallic acid and protocatechuic acid were found to have significant anti-tumor effects.
This paper summarizes the phytochemistry, pharmacology, clinical applications, safety, and toxicity of sea buckthorn in order to better understand the mechanism of action of the various bioactive components in sea buckthorn, investigate its medicinal potential, and provide more options for the treatment of cardiovascular diseases.
Chen Y, He W, Cao H, Wang Z, Liu J, Wang B, Wang C. · Frontiers in cardiovascular medicine (2024)
In clinical trials, sea buckthorn was proven to be effective in managing lipid metabolism, blood pressure, and blood glucose levels in patients.
We also extensively reviewed the safety of sea buckthorn medicine and its toxicity to numerous organs.
To summarize, sea buckthorn has a beneficial effect on cardiovascular disease and may give a novel strategy for clinical intervention and therapy.
Based on the available information, however, it can be concluded that these bioactive metabolites favorably affect both bone and breast tissue health.
Martiniakova M, Penzes N, Biro R, Sarocka A, Kovacova V, Mondockova V, Ciernikova S, Omelka R. · Frontiers in pharmacology (2024)
In vitro studies have revealed the beneficial impacts of sea buckthorn and aforementioned flavonoids on both bone health (bone remodeling, mineralization, and oxidative stress) and breast tissue health (cancer cell proliferation, apoptosis, tumor growth, and metastatic behavior).
In vivo studies have documented their protective effects against disturbed bone microarchitecture and reduced bone strength in animal models of osteoporosis, as well as against tumor expansion and metastatic properties in animal xenograft models.
In any case, further research and clinical trials are needed to carefully evaluate the potential therapeutic benefits of sea buckthorn and its flavonoids.
A systematic review and meta-analysis of 15 RCTs found sea buckthorn improved blood lipids (TG, total/LDL cholesterol, HDL) — but ONLY in people with abnormal lipids — and had no effect on blood sugar, blood pressure, or BMI.
Geng Y et al. · Phytotherapy research : PTR (2022)
14Systematische Übersichtn=596 participants across 11 RCTs · very large study2012
There is no convincing evidence of the benefit of dietary supplements in eczema, and they cannot be recommended for the public or for clinical practice at present.
Bath-Hextall FJ, Jenkinson C, Humphreys R, Williams HC · Cochrane Database Syst Rev (2012)
Cochrane review of 11 RCTs (596 participants) of dietary supplements for atopic eczema, including a hempseed oil vs placebo trial
No convincing evidence that dietary supplements as a class benefit eczema
Provides an honest counterweight to the single positive hempseed-oil crossover