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Slk2.5

Selank – Forschung

Überwiegend Mechanismus / Beobachtung

9 begutachtete Studien

Was die Evidenz sagt

Überwiegend Mechanismus / Beobachtung

Die meisten Studien zu Selank sind mechanistisch oder beobachtend statt RCTs, die einen klinischen Effekt messen — betrachte die Ergebnisse als vorläufig.

Die meiste Evidenz stammt aus gemischt-qualitativen randomisierten Studien, veröffentlicht 2008–2021 mit einer typischen Studiengröße von 52 Teilnehmenden.

Basierend auf 9 Studien · 2 RCTs · 52 Teilnehmende insgesamt

Konfidenz

Geringe Konfidenz

Nach Outcome

Anxiety & stressDie anxiolytische Wirkung ist in Nagetiermodellen konsistent; die Evidenz beim Menschen beschränkt sich auf kleine, überwiegend russische Studien, darunter eine Add-on-Studie bei Angststörungen · Tage bis Wochen (kleine Studien)
Überwiegend Mechanismus / Beobachtung6 Studien
Cognitive function
Überwiegend Mechanismus / Beobachtung3 Studien
Immune support
Zu wenige bewertete Studien2 Studien

Stetige Forschung

1 Studie in den letzten 5 Jahren

200820142021

1RCT2015

Medvedev VE, Tereshchenko ON, Kost NV, Ter-Israelyan AY, Gushanskaya EV, Chobanu IK · Zh Nevrol Psikhiatr Im S S Korsakova (2015)

Quelle ansehen

2RCT2008

Zozulia AA, Neznamov GG, Siuniakov TS, Kost NV, Gabaeva MV, Sokolov OIu · Zh Nevrol Psikhiatr Im S S Korsakova (2008)

3Übersicht2021

Einfach gesagt: Phenibut and selank are poorly studied Russian drugs with GABAergic mechanisms that are inexplicably sold to US consumers as dietary supplements.

Doyno CR, White CM. · Journal of Clinical Pharmacology (2021)

Independent (US) pharmacology review of GABA-receptor-acting sedative-hypnotics, including selank
Characterizes selank as poorly studied and notes it is sold to US consumers as a dietary supplement despite lacking that regulatory basis
Frames selank's mechanism as GABAergic alongside other CNS-depressant agents of abuse concern

Quelle ansehen

4Open-Labeln=52 · small study2020

Einfach gesagt: Post hoc analysis allowed us to define both general and specific effects of Selank and Semax on FC between the right amygdala and the right temporal cortex for the first time.

Panikratova YR, Lebedeva IS, Sokolov OY, Rumshiskaya AD, Kupriyanov DA, Kost NV. · Doklady biological sciences (2020)

Resting-state fMRI in 52 healthy participants, comparing intranasal selank, semax and placebo before and 5 and 20 min after injection
Focused on the amygdala (anxiety regulation) and dorsolateral prefrontal cortex (executive function)
Reported between-group and between-condition differences in functional connectivity between the right amygdala and right temporal regions

Quelle ansehen

5In vitro2018

Einfach gesagt: We hypothesized and showed that one of Selank anti-anxiety molecular mechanisms can be associated with subtype selective concentration-dependent allosteric modulation of GABA receptors.

Vyunova TV, Andreeva L, Shevchenko K, Myasoedov N. · Protein and Peptide Letters (2018)

Mechanistic review/study using radioligand-receptor binding to probe selank's anxiolytic mechanism
Reports selank acts as a positive allosteric modulator of [3H]GABA binding
Selank could block the modulatory activity of diazepam and olanzapine, suggesting partially overlapping but distinct binding sites

Quelle ansehen

6Tierstudie2019

Einfach gesagt: Selank produced a cognitive-stimulating effect in 9 months rats not exposed to ethanol and prevented the formation of ethanol-induced memory and attention disturbances developing during alcohol withdrawal.

Kolik LG, Nadorova AV, Antipova TA, Kruglov SV, Kudrin VS, Durnev AD. · Bulletin of Experimental Biology and Medicine (2019)

Rat study of selank (0.3 mg/kg/day, 7 days, intraperitoneal) on memory and BDNF after long-term ethanol exposure
Object-recognition cognitive benefit and prevention of ethanol-withdrawal memory/attention deficits
Selank prevented ethanol-induced rise in BDNF in hippocampus and frontal cortex, implicating a neurotrophin mechanism

Quelle ansehen

7Tierstudie2016

Einfach gesagt: The anxiolytic and nootropic efficiency of selank administered via both routes was observed only in BALB/c mice, which were characterized by initially higher levels of anxiety.

Vasil'eva EV, Kondrakhin EA, Salimov RM, Kovalev GI. · Eksperimental'naia i klinicheskaia farmakologiia (2016)

Compared intranasal vs intraperitoneal selank (300 μg/kg/day, 5 days) in two mouse strains using the elevated-plus-maze
Anxiolytic/nootropic effect appeared only in the high-anxiety BALB/c strain, not the low-anxiety C57BL/6 strain
Intraperitoneal selank increased frontal-cortex GABA-receptor binding; intranasal selank instead increased NMDA-receptor (MK-801) binding — route-dependent neurochemistry

8Tierstudie2014

Einfach gesagt: Selank and its short fragment Gly-Pro influence the expression of genes that mediate different types of immune responses, thereby maintaining the balance of the immune system.

Kolomin T, Morozova M, Volkova A, Shadrina M, Andreeva L, Slominsky P. · Molecular Immunology (2014)

Studied selank and its fragment Gly-Pro on inflammation-related gene expression (C3, Casp1, Il2rg, Xcr1) in mouse spleen after a single 100 μg/kg dose
Found rapid, time-dependent changes in immune-gene expression, with the Gly-Pro fragment largely reproducing selank's profile
Supports the tuftsin-derived immunomodulatory rationale for selank

Quelle ansehen

9Tierstudie2012

Einfach gesagt: The data obtained reveal a new target for selank in CNS and indicate significance of the activity of enkephalin-opioid system in individual sensitivity to selank.

Kozlovskii II, Andreeva LA, Kozlovskaia MM, Nadorova AV, Kolik LG. · Eksperimental'naia i klinicheskaia farmakologiia (2012)

Mouse open-field study of selank's anxiolytic effect under naloxone (opioid blockade) in high- and low-anxiety inbred strains
Selank (0.25 mg/kg i.p.) showed anxiolytic activity in high-anxiety BALB/C mice but not C57BL/6 mice
Naloxone pretreatment altered sensitivity to selank, implicating the enkephalin-opioid system in its effect

In der Forschungsbibliothek ansehen

Selank – Forschung

Überwiegend Mechanismus / Beobachtung

[Optimization of the treatment of anxiety disorders with selank].

[Efficacy and possible mechanisms of action of a new peptide anxiolytic selank in the therapy of generalized anxiety disorders and neurasthenia].

Sedative-Hypnotic Agents That Impact Gamma-Aminobutyric Acid Receptors: Focus on Flunitrazepam, Gamma-Hydroxybutyric Acid, Phenibut, and Selank.

Functional Connectomic Approach to Studying Selank and Semax Effects.

Peptide-based Anxiolytics: The Molecular Aspects of Heptapeptide Selank Biological Activity.

Selank, Peptide Analogue of Tuftsin, Protects Against Ethanol-Induced Memory Impairment by Regulating of BDNF Content in the Hippocampus and Prefrontal Cortex in Rats.

Comparison of pharmacological effects of heptapeptide Selank after intranasal and intraperitoneal administration to BALB/c and C57BL/6 mice.

The temporary dynamics of inflammation-related genes expression under tuftsin analog Selank action.

[The role of opioid system in peculiarities of anti-anxiety effect of peptide anxiolytic selank].