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Sk4.5
Shiitake – Forschung
Hilft vermutlich
65 begutachtete Studien
Was die Evidenz sagt
Hilft vermutlich
Shiitake half in etwa der Hälfte (2/4) der Studien, die einen Effekt gemessen haben — vielversprechend, aber nicht einhellig.
Die meiste Evidenz stammt aus hochwertigen Meta-Analysen und randomisierten Studien, veröffentlicht 1983–2026 mit einer typischen Studiengröße von 52 Teilnehmenden.
Basierend auf 65 Studien · 6 Meta-Analysen · 29 RCTs · 6,442 Teilnehmende insgesamt
Konfidenz
Hohe Konfidenz
Was die Studien gefunden haben
2geholfen2unklar· 61 weitere ohne bewertete Effektdaten
Nach Outcome
Therapeutic & clinical
Gemischte Evidenz55 Studien
Immune supportVerbesserte Funktion der Immunzellen · 4 weeks
Cancer patients (lung, colorectal, gastric cancer)1
Aktives Forschungsgebiet
32 Studien in den letzten 5 Jahren · Neueste Meta-Analyse: 2024
198320042026
1Beta-glucan effects in cancer treatmentSystematische Übersichtn=1,650 · large study2021
Einfach gesagt: It was observed that the administration of β-glucan is safe and well-tolerated.
Steimbach L et al. · Clinical nutrition (Edinburgh, Scotland) (2021)
It was observed that the administration of β-glucan is safe and well-tolerated.
Most of the trials pointed that concomitant administration of β-glucan with chemo or radiotherapy reduced the immune depression caused by such treatments and/or accelerated the recovery of white blood cells counts.
However, some articles also commented that no statistical difference was encountered between β-glucan treated vs. control groups, which gives a controversial conclusion about the β-glucan effects.
3Anti-cancer effects of edible/medicinal mushroomsÜbersicht2025
Einfach gesagt: In this review, we aim to analyze the anti-cancer effects of edible/medicinal mushrooms, including Schizophyllum commune, Trametes versicolor, Grifola frondosa, Ganoderma lucidum, Lentinula edodes, Laetiporus sulphureus, Boletus edulis, and Phellinus igniarius, as well as their potential anti-cancer mechanisms, providing strong theoretical support for the further development of edible/medicinal mushroom anti-cancer products.
Górska-Jakubowska S et al. · Nutrients (2025)
In recent years, the incidence rate of cancer has been on the rise all over the world, and the age of cancer patients has shown a younger trend, which seriously endangers patients' health.
Although the anti-cancer potential of edible and medicinal mushrooms has been widely studied in the past, this review focuses on the most recent literature from the last five years, providing an up-to-date and comprehensive summary of the current findings.
5Medicinal and therapeutic potentials of shiitakeÜbersicht2025
Einfach gesagt: SMs demonstrate translational potential for pharmaceutical and functional food applications; further studies are needed to elucidate their mechanisms and develop standardized, evidence-based formulations.
Baral B · Chemistry & biodiversity (2025)
Advances in processing technologies have mitigated the toxicity risks associated with prolonged use, thereby enhancing the safety profiles for therapeutic applications.
Emerging evidence also supports its role in dermatological health.
Furthermore, rigorous analytical characterization of its bioactive profile is critical for standardization and quality control.
Oba K, Kobayashi M, Matsui T, Kodera Y, Sakamoto J · Anticancer Res (2009)
7Fungal bioactive molecules for longevity medicinesÜbersicht2023
Einfach gesagt: Maitake or hen-of-the-woods), the genus Pleurotus (e.g. oyster mushrooms), and Agaricus subrufescens (i.e. the almond mushroom).
Shevchuk Y et al. · Ageing research reviews (2023)
Maitake or hen-of-the-woods), the genus Pleurotus (e.g. oyster mushrooms), and Agaricus subrufescens (i.e. the almond mushroom).
We propose that further research on fungal extracts will provide a greater picture of the role fungi-derived bioactive molecules can have in developing longevity and neuroprotective medicines for humans.
8Anti-cancer potential in breast cancerÜbersicht2023
Einfach gesagt: We also report insights into the relationship between dietary consumption of edible mushrooms and breast cancer risk, and the results of clinical studies and meta-analyses focusing on the effects of fungal extracts on breast cancer patients.
Gariboldi MB et al. · International journal of molecular sciences (2023)
In this article, we reviewed mushrooms showing antineoplastic activity again breast cancer cells, especially focusing on the possible bioactive compounds involved and their mechanisms of action.
In particular, the following mushrooms have been considered: Agaricus bisporus, Antrodia cinnamomea, Cordyceps sinensis, Cordyceps militaris, Coriolus versicolor, Ganoderma lucidum, Grifola frondosa, Lentinula edodes, and Pleurotus ostreatus.
We also report insights into the relationship between dietary consumption of edible mushrooms and breast cancer risk, and the results of clinical studies and meta-analyses focusing on the effects of fungal extracts on breast cancer patients.
9Vitamin B12 content in non-animal foodsSystematische Übersichtn=25 · very small study2023
Einfach gesagt: Future research should consider different methods of storage, preparation, fermented foods and standardization of the production of certain foods.Supplemental data for this article is available online at https://doi.org/10.1080/10408398.2022.2053057.
Marques de Brito B et al. · Critical reviews in food science and nutrition (2023)
In the last decade, more sensitive method for real B12 determination was used, the liquid chromatography-electrospray ionization tandem mass spectrometry chromatograms.
It is possible that daily recommendations for B12 can be met by a varied diet containing non-animal B12 food sources.
Future research should consider different methods of storage, preparation, fermented foods and standardization of the production of certain foods.Supplemental data for this article is available online at https://doi.org/10.1080/10408398.2022.2053057.
10Lentinan effects in inflammatory and tumor diseasesÜbersicht2024
Einfach gesagt: Lentinan (lLNT) is an active substance extracted from shiitake mushrooms with powerful antioxidant, anti-inflammatory, anti-tumor functions.
Zhou G et al. · European journal of medical research (2024)
Moreover, clinical experiments have confirmed that LNT combined with chemotherapy drugs has a significant effect in improving the prognosis of patients, enhancing their immune function and reducing the side effects of chemotherapy in lung cancer, colorectal cancer and gastric cancer.
LNT has been approved as an adjunct to chemotherapy in China and Japan.
Therefore, this article reviews the mechanism and clinical research of LNT in inflammatory diseases and tumor diseases in recent years.
11Medicinal mushroom effects on human organismÜbersicht2023
Einfach gesagt: This review focuses on the properties of selected medicinal mushrooms and their effects on the human organism and presents current knowledge on the possibilities of their use in the production of functional foods.
Łysakowska P et al. · Molecules (Basel, Switzerland) (2023)
Detailed mechanisms of the effects of medicinal mushrooms on the human organism still require long-term clinical studies to confirm their nutraceutical effects, their safety of use, and their dosage.
Medicinal mushrooms have great potential to be used in the design of innovative functional foods.
There is a need for further research on the possibility of incorporating mushrooms into food products to assess the interactions of their bioactive substances with ingredients in the food matrix.
12Cancer regression and immune prophylaxisÜbersicht2021
Einfach gesagt: These observations indicate that regression of advanced inoperable cancers and long-lasting cancer immune prophylaxis can be reached by simple approaches.
Bukovsky A · Histology and histopathology (2021)
An otherwise untreated rectal cancer, progressing over 3 years, regressed after severe toxic dermatitis lasting over one week.
This was caused by an accidental consumption of a large raw shiitake mushroom.
These observations indicate that regression of advanced inoperable cancers and long-lasting cancer immune prophylaxis can be reached by simple approaches.
13Rice bran arabinoxylan modified with shiitake enzyme effectsÜbersicht2021
Einfach gesagt: Nevertheless, further research in both basic studies and human clinical trials are required to investigate the clinical applications, mechanisms, and effects of RBAC.
Ooi SL et al. · Molecules (Basel, Switzerland) (2021)
Additionally, RBAC has been shown to ameliorate irritable bowel syndrome and protect against liver injury caused by hepatitis or nonalcoholic fatty liver disease.
It can potentially ease symptoms in chronic fatigue syndrome and prevent the common cold.
RBAC is safe to consume and has no known side effects at the typical dosage of 2-3 g/day.
Einfach gesagt: In this review, we discuss the immunomodulatory properties of various polysaccharides from L. edodes in animal models and in humans.
Roszczyk A et al. · International journal of molecular sciences (2022)
Lentinula edodes (Berk.) Pegler, also known as shiitake mushroom, is a popular edible macrofungus and a source of numerous bioactive substances with multiple beneficial health effects.
L. edodes-derived polysaccharides are the most valuable compounds, with anticancer, antioxidant, antimicrobial, and immunomodulatory properties.
It has been demonstrated that their biological activity depends on the extraction method, which affects monosaccharide composition, molecular weight, branching degrees, and helical conformation.
15Beta-glucan supplementation effects on healthSystematische Übersicht2021
Einfach gesagt: Supplementation with beta-(1 → 3,1 → 6)-d-glucans is well-tolerated, and health-promoting properties are manifested primarily through the potentiation of the immune system.
Vlassopoulou M et al. · Food & function (2021)
Supplementation with beta-(1 → 3,1 → 6)-d-glucans is well-tolerated, and health-promoting properties are manifested primarily through the potentiation of the immune system.
More studies are required to confirm their additional beneficial effects, to establish the optimal dose, and to reveal the underlying molecular mechanisms.
Einfach gesagt: Little, however, has been written about some-of the supplements in widely used in Japan and China, but relatively unheard of in the United States.
Shah SK et al. · JPEN. Journal of parenteral and enteral nutrition (2011)
There has been a growing interest in stimulation of the immune system in trauma, cancer, and surgical patients in general.
Little, however, has been written about some-of the supplements in widely used in Japan and China, but relatively unheard of in the United States.
Einfach gesagt: Here, we review in vivo and in vitro effects of AHCC® on NK and T cells of humans and animals in health and disease, providing a platform for the better understanding of immune-mediated mechanisms and clinical implications of AHCC®.
Shin MS et al. · Journal of immunology research (2019)
Mushrooms have been used for various health conditions for many years by traditional medicines practiced in different regions of the world although the exact effects of mushroom extracts on the immune system are not fully understood.
AHCC® is a standardized extract of cultured shiitake or Lentinula edodes mycelia (ECLM) which contains a mixture of nutrients including oligosaccharides, amino acids, and minerals obtained through liquid culture.
Here, we review in vivo and in vitro effects of AHCC® on NK and T cells of humans and animals in health and disease, providing a platform for the better understanding of immune-mediated mechanisms and clinical implications of AHCC®.
Einfach gesagt: In a more positive vein, the presence of potent toxins and neurotropic compounds in basidiomycete fruit bodies suggests that secondary metabolites with useful pharmacological properties are widespr...
Money NP · Fungal biology (2016)
In a more positive vein, the presence of potent toxins and neurotropic compounds in basidiomycete fruit bodies suggests that secondary metabolites with useful pharmacological properties are widespread in these fungi.
Major investment in controlled experiments and objective clinical trials is necessary to develop this natural pharmacopeia.
Einfach gesagt: This review examines the current information on the role of UV radiation in enhancing the concentration of vitamin D₂ in mushrooms, the effects of storage and cooking on vitamin D₂ content, and the bioavailability of vitamin D₂ from mushrooms.
Cardwell G et al. · Nutrients (2018)
The most common form of vitamin D in mushrooms is D₂, with lesser amounts of vitamins D₃ and D₄, while vitamin D₃ is the most common form in animal foods.
Worldwide mushroom consumption has increased markedly in the past four decades, and mushrooms have the potential to be the only non-animal, unfortified food source of vitamin D that can provide a substantial amount of vitamin D₂ in a single serve.
This review examines the current information on the role of UV radiation in enhancing the concentration of vitamin D₂ in mushrooms, the effects of storage and cooking on vitamin D₂ content, and the bioavailability of vitamin D₂ from mushrooms.
Einfach gesagt: Moreover, both randomized trials and long-term follow-up studies are needed to confirm their effectiveness in the treatment of IBD and CRC.
Bugajewski M, Angerhoefer N, Pączek L, Kaleta B. · International journal of molecular sciences (2025)
Moreover, clinical trials confirmed that these compounds combined with standard chemotherapy have a significant effect in improving the prognosis of CRC patients.
In addition, L. edodes glucans increase microbial diversity and enhance interferon (IFN)-γ production by immune cells.
Future studies must be focused on understanding the pathways and mechanisms associated with the observed effects.