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Shj5.0
Shilajit – Forschung
Überwiegend Mechanismus / Beobachtung
25 begutachtete Studien
Was die Evidenz sagt
Überwiegend Mechanismus / Beobachtung
Die meisten Studien zu Shilajit sind mechanistisch oder beobachtend statt RCTs, die einen klinischen Effekt messen — betrachte die Ergebnisse als vorläufig.
Die meiste Evidenz stammt aus hochwertigen Meta-Analysen und randomisierten Studien, veröffentlicht 2007–2026 mit einer typischen Studiengröße von 63 Teilnehmenden.
Basierend auf 25 Studien · 1 Meta-Analyse · 11 RCTs · 1,166 Teilnehmende insgesamt
Konfidenz
Hohe Konfidenz
Was die Studien gefunden haben
1geholfen· 24 weitere ohne bewertete Effektdaten
Nach Outcome
Safety profile
Überwiegend Mechanismus / Beobachtung7 Studien
Therapeutic & clinical
Überwiegend Mechanismus / Beobachtung6 Studien
Energy & fatigueEnergie-Behauptungen stützen sich auf Übersichtsarbeiten und Tierdaten, nicht auf Humanstudien · 2-4 weeks
Überwiegend Mechanismus / Beobachtung5 Studien
Men's vitalityEine kleine RCT (n=75) erhöhte das Testosteron über 90 Tage · 8-12 weeks · Kleine RCTs zeigen Verbesserungen des Testosterons und der Spermienqualität · 4-12 weeks
Überwiegend Mechanismus / Beobachtung4 Studien
Inflammation
Überwiegend Mechanismus / Beobachtung4 Studien
Bone healthEine kleine RCT erhielt die Knochendichte bei postmenopausaler Osteopenie · 8-12 weeks
Überwiegend Mechanismus / Beobachtung3 Studien
Neuroprotection & brain aging
Überwiegend Mechanismus / Beobachtung3 Studien
Cognitive function
Überwiegend Mechanismus / Beobachtung3 Studien
Weight management
Zu wenige bewertete Studien2 Studien
Fertility & reproductive
Zu wenige bewertete Studien1 Studie
Muscle strength & powerEine kleine RCT zeigte einen Erhalt der Kraft unter Ermüdung · 8-12 weeks
Zu wenige bewertete Studien1 Studie
Skin health
Zu wenige bewertete Studien1 Studie
Women's healthEine kleine RCT (n=75) erhöhte das gesamte und freie Testosteron · 4-8 weeks
Zu wenige bewertete Studien1 Studie
Glucose & metabolic
Zu wenige bewertete Studien1 Studie
In Zahlen
Aus 14 Studien mit messbaren Effekten gezogen
Wahrscheinlich echte Effekte
100%
über Studien hinweg
Untersuchte Personen
1,166
typische Studie: 63 Personen
Stärkste Designs
12
1 gepoolt, 11 randomisiert
Zeigte Nutzen
100%
1/1 Studien
Wie lange Studien liefen
1–4 Wochen
1
1–3 Monate
2
3+ Monate
2
Untersuchte Populationen
Male athletes1
Alzheimer's disease prevention1
Alzheimer's disease patients1
Patients with chronic fatigue syndrome1
Aktives Forschungsgebiet
13 Studien in den letzten 5 Jahren · Neueste Meta-Analyse: 2024
200720162026
1Serum total testosteroneSystematische ÜbersichtCited 5×n=52 · small study2024
Morgado A et al. · International journal of impotence research (2024)
Testosterone boosters are heavily marketed on social media and marketplaces to men with claims to significantly increase testosterone.
Our findings indicate that most fail to increase total testosterone.
The exceptions were β-hydroxy β-methylbutyrate and betaine, which can be considered effective for male athletes.
Hussain A et al. · Biological trace element research (2024)
The levels of reported metals in Shilajit were found to be lower than the permissible limits set by WHO and FDA, except in few studies where exceeded levels were reported.
Shilajit consumption without knowing permissible levels of metals is not safe and could pose serious health problems.
Although the humic substances and few metals in Shilajit are beneficial in terms of chelating toxic heavy metals, the data on metal detoxification still needs to be clarified.
We emphasize the relevance of nutraceuticals as a main actor in the prevention and/or control of dementia and particularly AD.
Maccioni RB et al. · Biomolecules (2022)
Based on markers data, early preventive interventions could reduce more than 40% of AD cases.
Anti-inflammatory agents with anti-aggregation properties that help to control cognitive impairment, include quercetin, biocurcumin, rosemarinic acid, and Andean shilajit.
Anthocyanidins, e.g., delphinidin, malvidin, and natural flavonoids, are also included.
Additional well-controlled human and animal studies involving the use of standardized products are needed.
Stohs SJ · Phytotherapy research : PTR (2014)
Furthermore, animal and human data support its use as a 'revitalizer', enhancing physical performance and relieving fatigue with enhanced production of ATP.
Key constituents in shilajit responsible for these effects appear to be dibenzo-α-pyrones and fulvic acid and their derivatives.
Various mechanistic studies provide support for the above observed effects.
This integrated view on nutraceutical opens a new pathway for future investigations and clinical trials that are likely to render some results based on medical evidence.
Calfio C et al. · Journal of Alzheimer's disease : JAD (2020)
In addition, we also discuss the activity of nutraceutical compounds and phytopharmaceuticals formulae, mainly directed to tau protein aggregates mechanisms of action.
These include compounds such as curcumin, resveratrol, epigallocatechin-3-gallate, morin, delphinidins, quercetin, luteolin, oleocanthal, and meganatural-az and other phytochemicals such as huperzine A, limonoids, azaphilones, and aged garlic extract.
Finally, we revise the nutraceutical formulae BrainUp-10 composed of Andean shilajit and B-complex vitamins, with memory enhancement activity and the control of neuropsychiatric distress in AD patients.
We analyze the status of biological studies and present data of a clinical trial developed in patients with mild AD.
Carrasco-Gallardo C et al. · Archives of medical research (2012)
We analyze the status of biological studies and present data of a clinical trial developed in patients with mild AD.
Studies suggest that shilajit and its active principle fulvic acid, as well as a formula of shilajit with B complex vitamins, emerge as novel nutraceutical with potential uses against this brain disorder.
Based on the earlier studies, the bioactivity of shilajit lacks substantial evidence.
Wilson E et al. · Journal of ethnopharmacology (2011)
Based on the earlier studies, the bioactivity of shilajit lacks substantial evidence.
Nevertheless, further studies are imperative to overcome the lacuna in establishing the antioxidant property of shilajit and more specific assays are needed to vouch shilajit as an immuno-modulator which may be of use to establish its rasayana potential.
Shilajit has been attributed with many miraculous healing properties.
Agarwal SP et al. · Phytotherapy research : PTR (2007)
It has been found to consist of a complex mixture of organic humic substances and plant and microbial metabolites occurring in the rock rhizospheres of its natural habitat.
Shilajit has been used as a rejuvenator and an adaptogen for thousands of years, in one form or another, as part of traditional systems of medicine in a number of countries.
Many therapeutic properties have been ascribed to it, a number of which have been verified by modern scientific evaluation.
Methods: In total, 166 sedentary men and women with at least two markers of metabolic syndrome participated in a randomized, placebo-controlled, parallel-arm, and repeated-measure intervention study, of which 109 completed the study (48.6 ± 10 yrs., 34.2 ± 6 kg/m2, 41.3 ± 7% fat).
Data were obtained at 0, 6, and 12 weeks of supplementation, and analyzed using general linear model multivariate and univariate analyses with repeated measures, pairwise comparisons, and mean changes from the baseline with 95% confidence intervals (CIs).
Differences among groups were more consistently seen at 6 weeks rather than 12 weeks.
11Tibial bone union healing timeRCTCited 10×n=160 · medium study2020
Conclusions: The current study showed that oral consumption of momiai after tibial shaft fracture surgery could be a promising option to reduce the healing time.
Sadeghi SMH et al. · Journal of alternative and complementary medicine (New York, N.Y.) (2020)
Spürbar Nutzen
← SchlechterKein EffektBesser →
Likely real
There was no significant difference between groups in terms of demographic and descriptive data.
At the end of the study, the mean time of tibial bone union was 129 days in the experimental group, while it was 153 days in the placebo group (p < 0.049).
There was no significant difference in the reported adverse effects between the two groups (p = 0.839).
This meta-analysis consolidates clinical RCT evidence for shilajit's androgenic effects, relevant for its use in male vitality and energy supplementation.
Rathore et al. · Phytotherapy Research (2024)
Shilajit supplementation significantly increased total testosterone levels versus placebo across included RCTs
Free testosterone and DHEA-S concentrations were meaningfully elevated in the treatment groups
No serious adverse events were reported across included trials, supporting the supplement's safety profile
13Bone mineral density preservationRCTCited 22×n=60 · small study2022
Daily supplementation with this shilajit extract supports BMD in postmenopausal women with osteopenia in part by attenuating the increased bone turnover, inflammation and oxidative stress that coincides with estrogen deficiency in this population at increased risk for osteoporosis and bone fractures.
Pingali U et al. · Phytomedicine : international journal of phytotherapy and phytopharmacology (2022)
Likely real
CTX-1, BALP, and RANKL decreased, whereas OPG increased, in both groups supplemented with the shilajit extract, but not in the placebo group, resulting in significantly decreased or increased percentage changes from baseline, respectively.
MDA was significantly decreased (p < 0.001) and GSH was significantly increased (p < 0.001) in both supplemented groups compared to placebo from week 12 for the duration of the study.
Progressive reductions in hsCRP were observed in both supplemented groups, resulting in significantly decreased percentage changes from baseline in supplemented women compared to placebo (p < 0.001).
14Total and free testosterone levelsRCTCited 15×n=75 · small study2016
Treatment with Shilajit for consecutive 90 days revealed that it has significantly (P < 0.05) increased total testosterone, free testosterone and dehydroepiandrosterone (DHEAS) compared with placebo.
Pandit S et al. · Andrologia (2016)
Total testosterone increased significantly after 90 days of supplementation
Free testosterone also improved compared to placebo group
DHEA levels showed a trending increase alongside testosterone
In conclusion, 8 weeks of Shilajit supplementation with 500 and 1000 mg·d-1 increased type 1 collagen synthesis as indicated by serum levels of pro-c1α1.
Neltner TJ et al. · Journal of dietary supplements (2024)
Individual subject responses were assessed using the minimal clinically important difference and Chi-squared tests.
In conclusion, 8 weeks of Shilajit supplementation with 500 and 1000 mg·d-1 increased type 1 collagen synthesis as indicated by serum levels of pro-c1α1.
16Muscular strength retention and serum hydroxyproline levelsRCTCited 9×n=63 · small study2019
The results of the present study demonstrated that 8 weeks of PrimaVie® Shilajit supplementation at 500 mg·d- 1 promoted the retention of maximal muscular strength following the fatiguing protocol and decreased baseline HYP.
Keller JL et al. · Journal of the International Society of Sports Nutrition (2019)
The results of the present study demonstrated that 8 weeks of PrimaVie® Shilajit supplementation at 500 mg·d- 1 promoted the retention of maximal muscular strength following the fatiguing protocol and decreased baseline HYP.
Thus, PrimaVie® Shilajit supplementation at 500 mg·d- 1 elicited favorable muscle and connective tissue adaptations.
Das A et al. · Journal of the American College of Nutrition (2019)
At a higher dose (250 mg bid), shilajit improved skin perfusion when compared to baseline or the placebo.
Pathway analysis identified shilajit-inducible genes relevant to endothelial cell migration, growth of blood vessels, and ECM which were validated by quantitative real-time polymerase chain reaction (RT-PCR) analysis.
The study provided maiden evidence that oral Shilajit supplementation in adult overweight/class I obese human subjects promoted skeletal muscle adaptation through upregulation of ECM-related genes that control muscle mechanotransduction properties, elasticity, repair, and regeneration.
The results support continued investigation through rigorous, blinded studies, recognising that no clinical trials currently exist and that any potential clinical translation remains speculative at this stage.
Das SS, Ramkumar M, Singh H, Sharma S. · Cureus (2026)
In vivo findings suggested chemopotentiation and organ protection when administered together with standard therapy.
Thus, Shilajit shows multitargeted anticancer activities in various experimental cancer models by several mechanisms.
This evidence is preclinical, and standardization issues restrict clinical translation.
It also contains amino acids (mainly glycine) and proteins, fatty acids, bioactive compounds such as caffeic acid and gallic acid, and heavy metals including chromium, selenium, and cobalt.
Kamgar E, Kaykhaii M, Zembrzuska J. · Critical reviews in analytical chemistry (2025)
While there are many differences in the chemical compositions of Shilajit from various regions, it has been discovered that more than 80% of weight of Shilajit is mainly composed of humic substances and almost 20% of its weight consists of calcium, potassium, and magnesium.
Moreover, its source is not known; some believe that it is formed from dead plant residues or animal excrements, and some others believe it is a mineral secreted from rocks gradually.
In this review article, it is tried to gather chemical property information available regarding this soft, mysterious black material to clarify what it is composed of and what formulation commercial supplements and drugs based on Shilajit may have.