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Trs3.4

Trestolone (MENT) – Forschung

Überwiegend Mechanismus / Beobachtung

8 begutachtete Studien

Was die Evidenz sagt

Überwiegend Mechanismus / Beobachtung

Die meisten Studien zu Trestolone (MENT) sind mechanistisch oder beobachtend statt RCTs, die einen klinischen Effekt messen — betrachte die Ergebnisse als vorläufig.

Die meiste Evidenz stammt aus mittelwertigen randomisierten Studien, veröffentlicht 1995–2013 mit einer typischen Studiengröße von 45 Teilnehmenden.

Basierend auf 8 Studien · 5 RCTs · 74 Teilnehmende insgesamt

Konfidenz

Mittlere Konfidenz

Nach Outcome

Androgen replacement & sexual functionIn einer kleinen Crossover-Studie mit hypogonadalen Männern erhielten MENT-acetate-Implantate das sexuelle Interesse, spontane und nächtliche Erektionen sowie eine positive Stimmung aufrecht · Über den Implantationszeitraum hinweg (Wochen)
Überwiegend Mechanismus / Beobachtung7 Studien
Male contraception & fertility
Überwiegend Mechanismus / Beobachtung4 Studien
Safety profile
Zu wenige bewertete Studien2 Studien
Muscle & anabolism
Zu wenige bewertete Studien1 Studie

Ältere Forschungsbasis

Neueste Studie von 2013

199520042013

1RCT1999

Anderson RA, Martin CW, Kung AW, Everington D, Pun TC, Tan KC · J Clin Endocrinol Metab (1999)

Quelle ansehen

2RCT1999

Suvisaari J, Moo-Young A, Juhakoski A, Elomaa K, Saleh SI, Lähteenmäki P · Contraception (1999)

Quelle ansehen

3RCT2003

Anderson RA, Wallace AM, Sattar N, Kumar N, Sundaram K · J Clin Endocrinol Metab (2003)

Quelle ansehen

4RCT2003

von Eckardstein S, Noe G, Brache V, Nieschlag E, Croxatto H, Alvarez F · J Clin Endocrinol Metab (2003)

Quelle ansehen

5RCTn=29 · very small study2007

Einfach gesagt: Sperm concentrations fell rapidly to less than 1 x 10(6)/mL at 12 weeks in 8 of 10 subjects in the MENT group ... Thereafter, suppression was not maintained in the MENT group, and 6 men noted loss of libido ... MENT with a progestogen can achieve rapid suppression of spermatogenesis similar to testosterone, but this promising result was not sustained due to a decline in MENT release from the implants.

Walton MJ, Kumar N, Baird DT, Ludlow H, Anderson RA. · Journal of andrology (2007)

Randomized trial in 29 healthy men comparing MENT implants vs testosterone pellets, each with etonogestrel implants, for spermatogenic suppression over up to 48 weeks
MENT plus progestogen achieved rapid suppression of spermatogenesis similar to testosterone (8 of 10 men to <1 million/mL by 12 weeks) with equally suppressed gonadotropins
Crucial counter-evidence: suppression was NOT maintained because MENT release from the implants declined, and 6 men reported loss of libido — a delivery-system failure, not a potency failure; HDL-C fell and hemoglobin rose in both groups

Quelle ansehen

6Open-Labeln=45 · small study1999

Einfach gesagt: Two and four implants induced maximal suppression that was maintained throughout treatment and was completely reversed after removal of the implants. The mean decreases were 93 +/- 1% for testosterone, 80 +/- 3% for DHT, 97 +/- 1% for luteinizing hormone and 95 +/- 1% for follicle stimulating hormone.

Noé G, Suvisaari J, Martin C, Moo-Young AJ, Sundaram K, Saleh SI, Quintero E, Croxatto HB, Lähteenmäki P. · Human reproduction (Oxford, England) (1999)

Dose-finding study in 45 healthy men receiving 1, 2 or 4 subdermal MENT-acetate implants (~500 µg/day each) for 28 days, measuring serum MENT, gonadotropins, testosterone, DHT, SHBG, PSA and IGF-1
Two to four implants produced maximal, sustained and fully reversible suppression — ~97% LH, ~95% FSH, ~93% testosterone, ~80% DHT — confirming MENT's potent gonadotropin- and androgen-suppressive effect
No serious adverse reactions and no consistent clinical-chemistry/haematology changes over the short course

Quelle ansehen

7Übersicht2013

Einfach gesagt: The ensuing search for long-acting preparations yielded testosterone buciclate and undecanoate as well as 7α-methyl-19-nortestosterone (MENT) ... the systematic development of MENT for substitution of male hypogonadism and use in male contraception by the Population Council is reviewed here.

Nieschlag E, Kumar N, Sitruk-Ware R. · Contraception (2013)

Review by the program's principals (Nieschlag, Kumar, Sitruk-Ware) of the Population Council's development of MENT for male contraception and for treatment of hypogonadism
Frames MENT among the long-acting androgens sought for male hormonal contraception, and summarizes its systematic development as a replacement and contraceptive agent
Honest context anchor: documents that MENT remained investigational — a development program, not an approved, marketed product

Quelle ansehen

8Übersicht1995

Einfach gesagt: 7 alpha-methyl-19-nortestosterone (MENT) does not get 5 alpha-reduced due to steric hindrance from the 7 alpha-methyl group ... The fact that MENT is also aromatized to 7 alpha-methyl estradiol, a potent estrogen ... suggests that some of the anabolic actions of MENT may be mediated by this estrogen.

Sundaram K, Kumar N, Monder C, Bardin CW. · The Journal of steroid biochemistry and molecular biology (1995)

Foundational mechanism paper from the Population Council on why 19-norandrogens including MENT have high relative anabolic activity
MENT is NOT 5α-reduced (the 7α-methyl group sterically blocks it), so its androgenic potency is not amplified in the prostate — the prostate-sparing property
Crucial counterpoint: MENT IS aromatized to 7α-methylestradiol, a potent estrogen — establishing the estrogenic activity (and gynecomastia risk) that accompanies use

Quelle ansehen

In der Forschungsbibliothek ansehen

Trestolone (MENT) – Forschung

Überwiegend Mechanismus / Beobachtung

7Alpha-methyl-19-nortestosterone maintains sexual behavior and mood in hypogonadal men.

Pharmacokinetics of 7 alpha-methyl-19-nortestosterone (MENT) delivery using subdermal implants in healthy men.

Evidence for tissue selectivity of the synthetic androgen 7 alpha-methyl-19-nortestosterone in hypogonadal men.

A clinical trial of 7 alpha-methyl-19-nortestosterone implants for possible use as a long-acting contraceptive for men.

7alpha-methyl-19-nortestosterone (MENT) vs testosterone in combination with etonogestrel implants for spermatogenic suppression in healthy men.

Gonadotrophin and testosterone suppression by 7alpha-methyl-19-nortestosterone acetate administered by subdermal implant to healthy men.

7α-methyl-19-nortestosterone (MENTR): the population council's contribution to research on male contraception and treatment of hypogonadism.

Different patterns of metabolism determine the relative anabolic activity of 19-norandrogens.