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Trs3.4
Trestolone (MENT) – Forschung
Überwiegend Mechanismus / Beobachtung
28 begutachtete Studien
Was die Evidenz sagt
Überwiegend Mechanismus / Beobachtung
Die meisten Studien zu Trestolone (MENT) sind mechanistisch oder beobachtend statt RCTs, die einen klinischen Effekt messen — betrachte die Ergebnisse als vorläufig.
Die meiste Evidenz stammt aus hochwertigen randomisierten Studien, veröffentlicht 1995–2026 mit einer typischen Studiengröße von 45 Teilnehmenden.
Basierend auf 28 Studien · 4 RCTs · 554 Teilnehmende insgesamt
Konfidenz
Mittlere Konfidenz
Nach Outcome
Androgen replacement & sexual functionIn einer kleinen Crossover-Studie mit hypogonadalen Männern erhielten MENT-acetate-Implantate das sexuelle Interesse, spontane und nächtliche Erektionen sowie eine positive Stimmung aufrecht · Über den Implantationszeitraum hinweg (Wochen)
Überwiegend Mechanismus / Beobachtung16 Studien
Male contraception & fertility
Überwiegend Mechanismus / Beobachtung6 Studien
Safety profile
Überwiegend Mechanismus / Beobachtung4 Studien
Muscle & anabolism
Zu wenige bewertete Studien1 Studie
Aktives Forschungsgebiet
22 Studien in den letzten 5 Jahren
199520102026
1Systematische Übersicht2026
Future research directions, such as early biomarker identification and targeted pharmacological intervention, are also discussed.
Chen R, Bian M, Zhao J, Qian L, Shi Y, Wu Z. · Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences (2026)
Cone beam computed tomography (CBCT) is currently the key imaging modality for three-dimensional assessment and accurate staging of ECR.
This review systematically elaborates on the etiological factors, pathological mechanisms, clinical manifestations, image-based classification systems, diagnosis, and management of ECR, aiming to provide insights for precise clinical decision-making.
Future research directions, such as early biomarker identification and targeted pharmacological intervention, are also discussed.
By aligning with global sustainability goals and animal welfare standards, these innovations hold potential to sustainably meet the growing demands of poultry production systems.
Lu W, Peng H, Yang D. · Journal of animal physiology and animal nutrition (2026)
Emerging sustainable alternatives, including microbial-derived enzymes and insect-based proteins, offer cost-effective solutions to replace traditional additives while maintaining productivity.
However, challenges persist in balancing economic viability, regional feed resource variability, and the need for precision in oxidative stress manage-ment.
Future research must prioritise interdisciplinary strategies to develop regionally tailored formulations that integrate molecular insights with farm-scale feasibility.
This review examines the molecular mechanisms of the menin-KMT2A interaction, and summarizes clinical trial data on the efficacy and safety of menin inhibitors as monotherapy and in combination.
Alati C, Molica M, Pitea M, Marafioti V, Porto G, Policastro G, Bilardi E, Utano G, Giordano L, Sgarlata A, Delfino IM, Idato A, Santoro G, Rossi M, Martino M. · Cancers (2026)
The AUG-MENT-101 trial reported a 23% composite complete remission rate in heavily pretreated patients, with 61% of responders achieving MRD negativity.
Acquired resistance, often due to MEN1 mutations at the drug-binding interface, occurs in about 40% of cases.
Approximately 30-40% of responders in relapsed or refractory trials proceeded to allogeneic transplantation, which remains a key pathway to potential cure.
On the basis of that analysis, we advocate for the revision and expansion of public breast cancer screening policies to include women 40-49 and ≤ 70 years of age, as an essential strategy to reduce mortality, improve clinical outcomes, and promote greater equity in access to diagnosis and treat-ment of breast cancer in Brazil.
de Paula IB, Chala LF, Urban LABD, Bitencourt AGV, de Oliveira TMG, Couto HL, Moraes PC, Miranda BMM, Moraes TP, Mussauer ACMR, Canella EO, Bauab SDP, Oliveira ALK, Francisco JLE, Schaefer MB, Guimarães ADSG, Badan GM, Peixoto JE, Jakubiak RR. · Radiologia brasileira (2026)
This increase is particularly evident among women under 50 years of age and those 70 years of age or older, groups that account for a substantial proportion of diagnosed cases and registered deaths in the country.
This article analyzes epidemiological data, the socio-economic impacts of breast cancer, and the scientific evidence regarding mammography screening, discussing the outcomes and limitations of national programs in Brazil.
This article provides a clear summary of the current recommended procedures from initial resuscitation, fluid therapy, administration of blood substitutes, ad-justment of coagulation parameters in patients on anticoagulant and antithrombotic therapy, endoscopic diagnostic and therapeutic options, and procedures for recurrent bleeding, including angiointervention and surgical treatment, with a main focus on nonvariceal bleeding.
Hoskovec D. · Rozhledy v chirurgii : mesicnik Ceskoslovenske chirurgicke spolecnosti (2025)
The diagnosis and treatment require a multidisciplinary approach.
Today, endoscopy plays a key role in the diagnosis and treatment.
The correct timing of each step is essential for patient survival.
This paper contains numerous schematic drawings to demonstrate the surgically relevant anatomy.
Beneš M, Kachlík D, Kunc V. · Rozhledy v chirurgii : mesicnik Ceskoslovenske chirurgicke spolecnosti (2025)
The aim of this article is to present a compendious review of relevant anatomy and practical notes which may enhance the optimal functional outcomes.
Structured discussion on morphological aspects of the insertional tendon and its topography in relation to osseous and soft-tissue structures is presented.
Moreover, attention is paid to technical aspects of implantation of fixation devices, so that physiological and anatomical reconstruction can be assured.
Štefan M, Šindlerová R, Mihalčin M. · Klinicka mikrobiologie a infekcni lekarstvi (2025)
The standard duration of antibiotic therapy should not exceed 10 days, and it is often shorter (five to seven days).
In cases of necrotizing fasciitis or myonecrosis, early diagnosis, prompt surgical intervention, intensive care, and antibiotic treatment - typically a combination of a beta-lactam and clindamycin, based on the likely pathogen and entry site - are crucial.
The text highlights the importance of sound clinical judgment and appropriate antibiotic use as essential strategies to prevent the overuse of broad-spectrum antibiotics and curb antimicrobial resistance.
9Systematische Übersicht2025
Addressing nutrition and iron deficiency are important supportive measures.
Kaysin A, Swami S, Aluko O, Bultman DS. · FP essentials (2025)
Endothelin receptor antagonists, prostacyclin analogues, and phosphodiesterase 5 inhibitors are key treatment options.
Combination therapy is recommended for patients with moderate to severe disease, whereas parenteral prostanoids are indicated for advanced pulmonary arterial hypertension.
Right-sided heart failure, a major complication, is managed with fluid manage-ment and diuretics, with lung transplant evaluation and palliative shunt procedures considered for refractory cases.
10Beobachtungsstudie2025
Future research directions include gene therapy to regulate purine metabolism and artificial intelligence-assisted personalized treatment plans, to achieve precision medicine for tophaceous wounds.
He G, Lu S, Lu X, Liu Y. · Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences (2025)
Surgical reconstructions, including skin flap grafting and tendon or ligament reconstruction, are indicated for significant tissue loss or functional impairment.
The comprehensive treatment of tophaceous wounds requires multidisciplinary collaboration to balance local repair and systemic regulation for improved prognosis.
However, further large-scale clinical trials are necessary to confirm their long-term effects on human health and fertility, ensuring their viability as future contraceptive options.
Bania J, Wrona J, Fudali K, Stęga F, Rębisz PF, Murawski M. · Journal of clinical medicine (2025)
These agents show promise due to their ability to suppress follicle-stimulating hormone (FSH) and luteinizing hormone (LH), leading to effective spermatogenesis inhibition with minimal side effects.
Additionally, the phenomenon of spermatogenic rebound is considered.
Among the investigated agents, oral DMAU, 11β-MNTDC, and the Nestorone-testosterone gel appear to be the most promising candidates for male hormonal contraception due to their high efficacy, user-friendly administration, and favorable safety profiles.
This review systematically summarizes the characteristics of these diverse TME dimensions and highlights recent progress in targeted delivery strategies, to facilitate the development of more personalized and effective anticancer therapies.
Chen H, Zhang L, Li C. · Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences (2025)
Mechanical cues within the TME, including matrix stiffness and solid stress, significantly affect drug distribution and treatment efficacy, suggesting that mechanical remodeling represents a potential strategy to enhance therapeutic outcomes.
Concurrently, tumor-associated microbiota and their metabolites participate in immune regulation and metabolic reprogramming, contributing to tumor development and offering novel therapeutic targets.
Moreover, recent advances have broadened our understanding on the multilayered regulatory landscape of the TME through the investigation of previously underappreciated factors such as neural regulation, metabolic niche dynamics, spatiotemporal heterogeneity, and epigenetic modulation.
Conclusion This guideline provides recommendations to ensure appropriate and safe clinical practice of PN therapy in adult patients within the acute hospital setting.
Lum JHM, Yeong HEL, Tan PE, Salazar E, Lee T, Ng YC, Chong JNC, Yong PW, Ong JPL, Gooi SC, Fan KH, Chen W, Lim MY, Tay KV, Ng DHL. · Annals of the Academy of Medicine, Singapore (2025)
Introduction The primary objective of this guideline is to establish evidence-based recommendations for the clinical use of parenteral nutrition (PN) in adult patients within the acute hospital setting in Singapore.
Method An expert workgroup, consisting of healthcare practitioners actively involved in clinical nutrition support across all public health institutions, systematically evaluated existing evidence and addressed clinical questions relating to PN therapy.
However, the corticosteroid injection did not produce a statistically significant increase in patients' overall level of satisfaction after surgery.
Valedsaravi N, Semnani A, Moghadam M, Semnani F. · General dentistry (2025)
A value of P < 0.05 was considered statistically significant.
Postoperative pain was significantly lower in the dexamethasone group than in the placebo group both 2 days (P = 0.015) and 4 days (P = 0.002) after surgery.
Additionally, the dexamethasone group reported signifi¬cantly less postoperative swelling than the control group both 4 days (P = 0.004) and 7 days (P = 0.007) after sur¬gery.
17Beobachtungsstudie2025
Based on this study, an internal procedure is now being developed that will focus on coordination with emergency and other departments, emphasize obtaining blood cultures, and ensure the timely and correct administration of antibiotics, including their possible combinations, as well as antifungals.
Janská P, Arientová S, Burantová A, Holub M. · Klinicka mikrobiologie a infekcni lekarstvi (2025)
A history of conditions or treatments predisposing to neutropenia was noted in 74 % of patients.
Seventy-four percent were admitted following evaluation or referral from an emergency department or another specialist.
Blood cultures (at least two sets) were initially obtained in 80 % of cases.
Engelter ST, Enz LS, Ravanelli F, Kaufmann JE, Gensicke H, Schaedelin S, Luft AR, Globas C, Goeggel-Simonetti B, Fischer U, Strambo D, Kägi G, Nedeltchev K, Kahles T, Kellert L, Rosenbaum S, von Rennenberg R, Brehm A, Seiffge D, Renaud S, Brandt T, Sarikaya H, Zietz A, Wischmann J, Polymeris AA, Fischer S, Bonati LH, De Marchis GM, Peters N, Nolte CH, Christensen H, Wegener S, Psychogios MN, Arnold M, Lyrer P, Traenka C. · European stroke journal (2025)
Results Among the 122 participants in the as-treated analysis, 3/93 (3.2%) aspirin-treated participants had new clinical ( n = 1) and MRI-outcomes ( n = 2) between 3 and 6 months while 1/29 (3.4%) anticoagulated participants had an MRI-outcome ( n = 1).
This yields an absolute difference of 0.2% (95% CI -8.0% to 7.5%, p = 1.0).
Thus, studies balancing benefits versus harms of antithrombotic treatment beyond 3 months are warranted.
Adding the QFR measure-ment to OCT findings may enable better discrimination of patients with subsequent TVF post-DCB angioplasty for ISR.
Lu S, Pan L, Gu N, Deng Y, Deng C, Li X, Wang F, Zhao Y, Wang Z, Shi B. · Scientific reports (2025)
At the post-procedural DCB angioplasty, the vessel-level QFR was significantly lower in the TVF group (0.89 [IQR: 0.87, 0.93] vs. 0.93 [IQR: 0.91, 0.96]; P < 0.001) than in the non-TVF group.
Analysis of the qualitative characteristics of ISR lesions showed a significantly higher incidence of heterogeneous neointima in the TVF group compared with the non-TVF group (13 [48.15%] vs. 32 [18.08%]; P < 0.001).
In the multivariable Cox regression analysis, low vessel-level QFR (HR per 0.1 increase: 0.11; 95% CI: 0.03-0.41; P < 0.001) and heterogeneous neointima were independently associated with TVF.
NIMFRF may be preferable for some patients due to its favourable adverse effect profile.
Qu L, Sha S, He C, Chen HD, Wu Y. · Acta dermato-venereologica (2025)
ECCA scores decreased significantly at each follow-up visit, compared with baseline (p < 0.05).
Approximate 95% of subjects achieved "satisfied" or "very satisfied" improvement.
Significantly increased red area value, melanin index and erythema index levels were seen on the AFCO2 laser side at one month or 2 month, compared with the NIMFRF side (p < 0.05).