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Trt8.0

Tretinoin (Retin-A) – Forschung

Überwiegend Mechanismus / Beobachtung

7 begutachtete Studien

Was die Evidenz sagt

Überwiegend Mechanismus / Beobachtung

Die meisten Studien zu Tretinoin (Retin-A) sind mechanistisch oder beobachtend statt RCTs, die einen klinischen Effekt messen — betrachte die Ergebnisse als vorläufig.

Die meiste Evidenz stammt aus mittelwertigen Meta-Analysen und randomisierten Studien, veröffentlicht 1988–2022.

Basierend auf 7 Studien · 1 Meta-Analyse · 2 RCTs

Konfidenz

Mittlere Konfidenz

Nach Outcome

Photoaging, acne & skinGoldstandard-Retinoid zur topischen Anwendung bei Photoaging — reduziert feine Linien und Falten (verschreibungspflichtig) · 12-24 weeks · Gut belegtes Retinoid bei komedonaler und entzündlicher Akne (verschreibungspflichtig) · 8-12 weeks
Überwiegend Mechanismus / Beobachtung7 Studien
Epidermal & dermal remodeling
Zu wenige bewertete Studien2 Studien

Stetige Forschung

1 Studie in den letzten 5 Jahren · Neueste Meta-Analyse: 2022

198820052022

1RCT1988

In a 16-week randomized, double-blind, vehicle-controlled study, topical tretinoin improved photoaged skin.

Weiss, Ellis, Headington, Tincoff, Hamilton, Voorhees · JAMA (1988)

Randomized, double-blind, vehicle-controlled trial of topical tretinoin for photoaged forearm and facial skin
Tretinoin-treated skin showed reduced fine wrinkling and improved appearance versus vehicle
Clinical and histologic improvement over 16 weeks

2RCT1992

Tretinoin emollient cream produced significant improvement in fine wrinkling, mottled hyperpigmentation, and roughness of photodamaged skin.

Olsen, Katz, Levine, Shupack, Billys, Prawer, Gold, Stiller, Lufrano, Thorne · J Am Acad Dermatol (1992)

Multicenter double-blind vehicle-controlled trial of tretinoin emollient cream for photodamaged skin
Significant improvement in fine wrinkling, mottled hyperpigmentation, and tactile roughness versus vehicle
Demonstrated efficacy of a gentler emollient (cream) formulation

Quelle ansehen

3Meta-Analyse2022

physical - chemical peels, e.g. salicylic or mandelic acid (39·70%, 95% CrI 12·54-66·78%)

Mavranezouli I, Daly CH, Welton NJ, et al. · Br J Dermatol (2022)

NICE-commissioned network meta-analysis of 179 RCTs (~35,000 observations) ranking acne treatments
Chemical peels (salicylic or mandelic) were among the effective physical options for mild-to-moderate acne (~39.7% lesion reduction vs placebo)
Uncertainty was high, particularly for chemical peels; mandelic is grouped with salicylic rather than isolated

Quelle ansehen

4Open-Label2005

Long-term topical retinoic acid improved epidermal cell atypia and thickened the collagen band in the papillary dermis.

Cho, Lowe, Hamilton, Fisher, Voorhees, Kang · J Am Acad Dermatol (2005)

Long-term topical retinoic acid on photoaged human skin assessed histologically
Reduced epidermal cellular atypia and thickened the papillary-dermal collagen band
Direct histologic evidence of collagen remodeling underlying wrinkle effacement

Quelle ansehen

5Pilotstudie1996

Matrix-degrading metalloproteinases are induced in human skin within hours of UV, and pretreatment with retinoic acid inhibited their induction.

Fisher, Datta, Talwar, Wang, Varani, Kang, Voorhees · Nature (1996)

UVB induces matrix metalloproteinases (collagen/elastin-degrading enzymes) in human skin in vivo within hours
Pretreatment with topical retinoic acid (tretinoin) inhibited this MMP induction
Defines the molecular pathway of photoaging and how tretinoin antagonizes it

Quelle ansehen

6Systematische Übersicht2015

prevention via sensible photoprotection methods still remains the best current management option.

Poon F, Kang S, Chien AL · Photodermatol Photoimmunol Photomed (2015)

Systematic literature review (MEDLINE, EMBASE, Cochrane) of photoaging etiology and management
Two approaches: prevention of UV damage (sunscreen) and reversal of existing damage (topical retinoids, 5-FU)
Concludes prevention via photoprotection remains the best management option — contextualizing sunscreen as primarily preventive

Quelle ansehen

7Pilotstudie1990

Topical tretinoin increased anchoring fibrils within the epidermal-dermal junction of photoaged skin.

Woodley, Zelickson, Briggaman, Hamilton, Weiss, Ellis, Voorhees · JAMA (1990)

0.1% tretinoin vs vehicle applied to forearm skin for 4 months, with electron-microscopy biopsies
Tretinoin increased epidermal-dermal anchoring fibrils versus vehicle
Ultrastructural evidence for dermal remodeling by tretinoin

In der Forschungsbibliothek ansehen

Tretinoin (Retin-A) – Forschung

Überwiegend Mechanismus / Beobachtung

Topical tretinoin improves photoaged skin. A double-blind vehicle-controlled study.

Tretinoin emollient cream: a new therapy for photodamaged skin.

A systematic review and network meta-analysis of topical pharmacological, oral pharmacological, physical and combined treatments for acne vulgaris.

Long-term treatment of photoaged human skin with topical retinoic acid improves epidermal cell atypia and thickens the collagen band in papillary dermis.

Molecular basis of sun-induced premature skin ageing and retinoid antagonism.

Mechanisms and treatments of photoaging.

Treatment of photoaged skin with topical tretinoin increases epidermal-dermal anchoring fibrils. A preliminary report.