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Val5.5
Valerian Root – Forschung
Überwiegend Mechanismus / Beobachtung
16 begutachtete Studien
Was die Evidenz sagt
Überwiegend Mechanismus / Beobachtung
Die meisten Studien zu Valerian Root sind mechanistisch oder beobachtend statt RCTs, die einen klinischen Effekt messen — betrachte die Ergebnisse als vorläufig.
Die meiste Evidenz stammt aus hochwertigen Meta-Analysen und randomisierten Studien, veröffentlicht 1982–2025 mit einer typischen Studiengröße von 182 Teilnehmenden.
Basierend auf 16 Studien · 3 Meta-Analysen · 7 RCTs · 9,209 Teilnehmende insgesamt
Konfidenz
Hohe Konfidenz
Was die Studien gefunden haben
1geholfen· 15 weitere ohne bewertete Effektdaten
Nach Outcome
Safety profile
Überwiegend Mechanismus / Beobachtung9 Studien
Sleep & insomniaKann die subjektive Schlafqualität verbessern · 2-4 weeks · Moderate Verringerung der Einschlafzeit · 2-4 weeks · Kann die Schlafkontinuität moderat unterstützen; die Effekte auf nächtliches Erwachen sind inkonsistent · 2-4 weeks
6 Studien in den letzten 5 Jahren · Neueste Meta-Analyse: 2024
198220032025
1Sleep quality and associated disordersMeta-AnalyseCited 66×n=6,894 · very large study2020
However, due to the presence of multiple active constituents and relatively unstable nature of some of the active constituents, it may be necessary to revise the quality control processes, including standardization methods and shelf life.
Shinjyo N et al. · Journal of evidence-based integrative medicine (2020)
In addition, therapeutic benefits could be optimized when it was combined with appropriate herbal partners.
There were no severe adverse events associated with valerian intake in subjects aged between 7 and 80 years.
In conclusion, valerian could be a safe and effective herb to promote sleep and prevent associated disorders.
The available evidence suggests that valerian might improve sleep quality without producing side effects.
Bent S et al. · The American Journal of Medicine (2006)
An extensive literature search identified 16 eligible studies examining a total of 1093 patients.
A dichotomous outcome of sleep quality (improved or not) was reported by 6 studies and showed a statistically significant benefit (relative risk of improved sleep = 1.8, 95% confidence interval, 1.2-2.9).
There was evidence of publication bias in this summary measure, and most studies had significant methodologic problems.
Research must address herb-drug interactions, long-term effects, and biomarkers for personalized treatment. autism spectrum disorder, herbal medicines, narrative review, doses recommendation, therapeutic effects, side effects.
Aldekhail NM et al. · Alternative therapies in health and medicine (2025)
Passionflower and Valerian Root alleviate anxiety and hyperactivity through GABAergic pathways.
Herbal therapies may address core ASD symptoms (anxiety and hyperactivity) and comorbidities (sleep disturbances and gastrointestinal issues).
Standardization of herbal formulations and rigorous dosing protocols are needed.
4Systematische ÜbersichtCited 10×2021
Potential solutions to address research gaps are offered, for future research next steps, which is needed to strengthen the evidence and inform decisions.
Crawford C et al. · Journal of alternative and complementary medicine (New York, N.Y.) (2021)
Ingredients evaluated included Bacopa monnieri, choline, creatine, omega-3 fatty acids, Ginkgo biloba, ginseng, Rhodiola rosea, tyrosine, and valerian root, all in supplement form and compared with a placebo, at various serving sizes and durations of use.
Whereas certain trends regarding promising serving sizes or duration for use, are pointed to in this synthesis, when combined, studies are inconsistent and imprecise, and many are methodologically flawed.
Potential solutions to address research gaps are offered, for future research next steps, which is needed to strengthen the evidence and inform decisions.
5Anxiety and sleep disordersSystematische ÜbersichtCited 11×2011
Valerian root is well tolerated and safe, with infrequent and benign side effects (SOR A).
Nunes A et al. · Acta medica portuguesa (2011)
There seems to be some evidence of the effectiveness of valerian for treating insomnia, which is limited by the quality of existing studies (SOR B).
The evidence is insufficient regarding the efficacy of valerian in the treatment of anxiety disorders (SOR A).
Valerian root is well tolerated and safe, with infrequent and benign side effects (SOR A).
6Early postoperative cognitive dysfunction after CABG surgeryRCTCited 16×n=61 · small study2015
We concluded that, based on this study, the cognitive state of patients in the valerian group was better than that in the placebo group after CABG; therefore, it seems that the use of V. officinalis root extract may prevent early postoperative cognitive dysfunction after on-pump CABG surgery.
Hassani S et al. · Psychopharmacology (2015)
Sehr groß Nutzen
← SchlechterKein EffektBesser →
Valerian prophylaxis reduced odds of cognitive dysfunction compared to placebo group (OR = 0.108, 95 % CI 0.022-0.545).
We concluded that, based on this study, the cognitive state of patients in the valerian group was better than that in the placebo group after CABG; therefore, it seems that the use of V. officinalis root extract may prevent early postoperative cognitive dysfunction after on-pump CABG surgery.
Further EEG studies are needed to confirm VRE's neurophysiological effects.
Roh D et al. · Phytotherapy research : PTR (2019)
Compared with the placebo group, the VRE group exhibited significantly greater increases in frontal brain region alpha coherence across four electrode pairs, and these changes were significantly correlated with anxiolysis.
Our findings indicate that VRE alters functional brain connectivity in relation to anxiety.
Further EEG studies are needed to confirm VRE's neurophysiological effects.
A one-time valerian 1600mg dose, often used to treat insomnia, does not appear to impair driving simulator performance after acute ingestion.
Thomas K et al. · Accident; analysis and prevention (2016)
There were no significant differences in the simple visual reaction test or sleepiness scales between placebo and valerian exposures, but the study may have been underpowered.
Field sobriety test total and individual test failure rates were not significantly different between the two exposures.
The driving simulator performance parameters were equivalent between the two exposure conditions.
This meta-analysis provides targeted evidence for valerian's sleep benefits in a specific high-need population (menopausal women), filling a gap in the existing literature.
Shayan M et al. · Menopause (2024)
Valerian supplementation significantly improved Pittsburgh Sleep Quality Index (PSQI) scores in menopausal women
No serious adverse events were reported across included trials
Effects were more pronounced in postmenopausal compared to perimenopausal subgroups
12Healthy aging and age-related disabilitiesSystematische Übersicht2025
Conclusions: Nutritional supplements and lifestyle changes may mitigate disabilities across multiple domains of age-related illnesses and promote healthy aging.
Kaufman MW, DeParis S, Oppezzo M, Mah C, Roche M, Frehlich L, Fredericson M. · American journal of lifestyle medicine (2025)
Magnesium, Vitamin D, and B vitamin supplementation have been shown to improve cognition in those with mild cognitive impairment and Alzheimer's disease but require further study prior to recommendation.
The Age-Related Eye Disease Study supplement combination is routinely recommended to reduce risk of progression to advance stages of age-related macular degeneration.
Alpha-Lipoic Acid and Folate have been investigated for their roles in mitigating age-related hearing losses.
13Mental energy benefits from dietary ingredientsSystematische Übersichtn=190 · medium study2024
This systematic-review examined the effects of Valerian Root.
Nieman KM, Zhu Y, Tucker M, Koecher K. · Journal of the American Nutrition Association (2024)
The search strategy for two ingredients did not yield any eligible studies, leaving studies for 16 ingredients that were extracted and summarized by reported significantly improved outcomes for cognition, mood and perceived feelings, and sleep assessments.
The preliminary results for several dietary ingredients directionally suggested a mental energy benefit (≥20% of outcomes), including ashwagandha, chamomile, dark chocolate, ginseng, green tea, lavender, lion's mane mushroom, maca, tart cherries, turmeric, and valerian root.
The results of this scoping review suggest that of the 16 dietary ingredients reviewed, 11 may be promising for further exploration on their potential benefits in supporting mental energy.
In total 9 non-serious adverse events were documented but the distribution did not differ significantly between the treatment groups.This herbal preparation (Ze185) showed to be an efficacious and safe short-term treatment in patients with somatoform disorders.
Melzer J et al. · Phytotherapy research : PTR (2009)
Analysis of the ITT population confirmed these results.
As to safety, no serious adverse events occurred.
In total 9 non-serious adverse events were documented but the distribution did not differ significantly between the treatment groups.This herbal preparation (Ze185) showed to be an efficacious and safe short-term treatment in patients with somatoform disorders.
15Sleep qualityRCTCited 137×n=128 · medium study1982
Valerian produced a significant decrease in subjectively evaluated sleep latency scores and a significant improvement in sleep quality.
Leathwood PD et al. · Pharmacology Biochemistry and Behavior (1982)
The effect of an aqueous extract of valerian root on subjectively rated sleep measures was studied on 128 people, who received placebo, 400 mg valerian extract, or a proprietary preparation.
Valerian produced a significant decrease in subjectively evaluated sleep latency scores and a significant improvement in sleep quality.
Night awakenings, dream recall and somnolence the next morning were relatively unaffected by valerian.
It is best to avoid high-titre alcoholic extracts and powdered valerian root, and to select aqueous extracts and low-titre hydro-alcoholic preparations.
Unknown authors · Prescrire international (2005)
Similarly, there are no scientific grounds for rejecting preparations based on hawthorn or passiflora. (5) Available data suggest that valerian extracts have a modest impact on subjective sleep quality; they are nevertheless more effective than a placebo.
Valerian products that do not contain valepotriates have no apparent adverse effects.
It is best to avoid high-titre alcoholic extracts and powdered valerian root, and to select aqueous extracts and low-titre hydro-alcoholic preparations.