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Vk14.0
Vitamin K1 – Forschung
Überwiegend Mechanismus / Beobachtung
10 begutachtete Studien
Was die Evidenz sagt
Überwiegend Mechanismus / Beobachtung
Die meisten Studien zu Vitamin K1 sind mechanistisch oder beobachtend statt RCTs, die einen klinischen Effekt messen — betrachte die Ergebnisse als vorläufig.
Die meiste Evidenz stammt aus hochwertigen randomisierten Studien, veröffentlicht 2006–2025 mit einer typischen Studiengröße von 35 Teilnehmenden.
Basierend auf 10 Studien · 1 RCT · 35 Teilnehmende insgesamt
Konfidenz
Geringe Konfidenz
Nach Outcome
Bone healthBescheidener, ergänzender Knochennutzen (schwächer als Vitamin K2 für die Knochen) · 6-12 months
Überwiegend Mechanismus / Beobachtung3 Studien
Heart & blood pressure
Zu wenige bewertete Studien2 Studien
Aktives Forschungsgebiet
8 Studien in den letzten 5 Jahren
200620152025
1Systematische Übersicht2025
This review aims to (i) provide an overview of the structure, dietary sources, metabolism, and physiological roles of vitamin K, including those relating to; cardiovascular diseases, type 2 diabetes, respiratory conditions, musculoskeletal health and cancer; (ii) discuss the impact of genetic factors on vitamin K status and how such factors modulate the role of vitamin K in the aforementioned chronic diseases; and (iii) outline key directions for future research.
Dupuy M, Bondonno NP, Pokharel P, Linneberg A, Levinger I, Schultz C, Hodgson JM, Sim M. · Food science & nutrition (2025)
Therefore, vitamin K has attracted considerable research interest for its potential implications in several diseases.
While promising, the specific roles of vitamin K in various health conditions, the quantity of vitamin K (both PK and MKs) required for the function of various VKDPs, and the influence of genetics on vitamin K metabolism, remain unclear.
More research related to synergism and the possible mechanisms of vitamins D3 and K interaction in bone health is needed.
Aaseth JO, Finnes TE, Askim M, Alexander J. · Nutrients (2024)
In addition, vitamin K acts on bone metabolism by other mechanisms, such as menaquinone 4 acting as a ligand for the nuclear steroid and xenobiotic receptor (SXR).
In this narrative review, we examine the evidence for increased bone mineralization through the dietary adequacy of vitamin K.
Summarizing the evidence for a synergistic effect of vitamin K and vitamin D3, we find that an adequate supply of vitamin K, on top of an optimal vitamin D status, seems to add to the benefit of maintaining bone health.
Finally, we track the development of a clinical concept for a future preventive strategy and innovative use of vitamin K as a supplement to counteract neurovascular and pathological processes, focusing in particular on stroke and dementia.
Grimaldi L, Cavallaro RA, De Angelis D, Fuso A, Sancesario G. · Molecules (Basel, Switzerland) (2025)
Recently, several studies have hypothesized a possible dual role of vitamin K vitamers in benefiting both vascular and cerebral health, e.g., by sphingolipids biosynthesis or ferroptosis inhibition.
The aim of this narrative review is to deepen the understanding of biological activities of vitamin K and its possible dual protective/preventive actions in neurovascular and degenerative conditions, e.g., stroke and dementia.
Given the difficulties related to hemorrhagic risk entailed in the prevention of strokes, the function of vitamin K antagonists is also investigated.
Here we review the latest advances in our understanding of how the different tomato paralogs of these three enzymes contribute to carotenoid biosynthesis in different plant tissues, developmental stages, and environmental conditions.
Rodriguez-Concepcion M, Lim S, Ha SH. · Journal of experimental botany (2025)
The first committed step of the carotenoid pathway is the condensation of two GGPP molecules to form phytoene, which is later converted into the rest of the carotenoid products.
Here we review the latest advances in our understanding of how the different tomato paralogs of these three enzymes contribute to carotenoid biosynthesis in different plant tissues, developmental stages, and environmental conditions.
These findings suggest the importance of oral VK1 supplementation in exclusively breastfed infants during their first 3 months of life to avoid the risk of VK insufficiency.
Perrone S, De Bernardo G, Lembo C, Dell'Orto V, Giordano M, Beretta V, Petrolini C, Gambini L, Toni AL, Parigi G, Fontanarosa I, Natale MP, D'Amato G, Sordino D, Buonocore G. · European journal of clinical investigation (2024)
Conclusions Oral supplementation of VK1 after discharge significantly reduced PIVKA-II concentrations in exclusively breastfed term infants.
At 1 and 3 months of life, infants who received any supplementation regimen between 2 and 14 weeks exhibited significantly lower PIVKA-II concentrations compared to infants who received only 1 mg of intramuscular VK1 at birth.
The prophylaxis involving a dose of 1 mg of intramuscular VK1 at birth followed by oral administration of 150 μg/day of VK1 from the 2nd to the 14th week of life showed the lowest PIVKA-II blood concentrations.
Considering the important role of vitamin K in the prevention of the skeletal system and cardiovascular diseases, it is necessary to increase its consumption by including fermented foods naturally containing menaquinones (MK-7) in the diet.
To provide infants with vitamin K2, it is extremely important to promptly introduce complementary foods into the diet that are sources of menaquinones.
Specifically formulated for the nutritional needs of young children products that contain naturally formed during milk fermentation vitamin K2, deserve special attention.
Considering the important role of vitamin K in the prevention of the skeletal system and cardiovascular diseases, it is necessary to increase its consumption by including fermented foods naturally containing menaquinones (MK-7) in the diet.
The analysis includes a review of published articles from multiple databases, including Scopus, PubMed, Google Scholar, ISI Web of Science and CNKI, focusing on human studies.
The findings indicate that VK2 is a versatile vitamin essential for human health and that a broadly positive correlation exists between VK2 supplementation and improved health outcomes.
However, clinical data are somewhat inconsistent, highlighting the need for further detailed research into VK2's metabolic processes, biomarker validation, dose-response relationships, bioavailability and safety.
A randomized trial found vitamin K1 added to bisphosphonate did NOT significantly change BMD or bone turnover; only a modest per-protocol effect on hip geometry.
Moore AE et al. · Arch Osteoporos (2023)
NO significant effect on bone density (BMD) or bone-turnover markers vs placebo
3-arm trial (K1 / MK-4 / placebo), ~35 per arm; only a modest per-protocol effect on hip geometry