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Vtx7.0
Vitex – Forschung
Hilft wahrscheinlich
55 begutachtete Studien
Was die Evidenz sagt
Hilft wahrscheinlich
Vitex scheint in 11 von 12 Studien mit messbaren Effekten zu helfen — die Evidenz tendiert klar ins Positive.
Die meiste Evidenz stammt aus hochwertigen Meta-Analysen und randomisierten Studien, veröffentlicht 1998–2026 mit einer typischen Studiengröße von 53 Teilnehmenden.
Basierend auf 55 Studien · 6 Meta-Analysen · 24 RCTs · 3,370 Teilnehmende insgesamt
Konfidenz
Hohe Konfidenz
Was die Studien gefunden haben
11geholfen1unklar· 43 weitere ohne bewertete Effektdaten
Nach Outcome
PMS, mastalgia & menstrualKann bei der Bewältigung von Wechseljahresbeschwerden wie Hitzewallungen und Stimmungsschwankungen helfen · 4-8 Wochen · Unterstützt einen gesunden Östrogenstoffwechsel und das hormonelle Gleichgewicht · 4-8 Wochen · Kann helfen, Menstruationsbeschwerden und PMS-Symptome zu reduzieren · 1-3 Zyklen
Hilft wahrscheinlich41 Studien
Safety profile
Hilft wahrscheinlich11 Studien
Therapeutic & clinical
Überwiegend Mechanismus / Beobachtung8 Studien
Fertility & reproductiveTraditionell zur Unterstützung der Lutealphase verwendet; die Evidenz zur Fruchtbarkeit ist schwach und nicht schlüssig · 4-12 Wochen
Überwiegend Mechanismus / Beobachtung3 Studien
Anxiety & stress
Überwiegend Mechanismus / Beobachtung3 Studien
Men's vitalityKann PMS-Symptome und das prolaktinbezogene hormonelle Gleichgewicht über 1-3 Zyklen unterstützen · 4-12 Wochen
Zu wenige bewertete Studien2 Studien
Pain & analgesia
Zu wenige bewertete Studien2 Studien
Depression & moodReduzierte PMS-Symptome und Zyklusregulierung · 1-3 Menstruationszyklen
Zu wenige bewertete Studien1 Studie
Sleep & insomnia
Zu wenige bewertete Studien1 Studie
Migraine & headache
Zu wenige bewertete Studien1 Studie
In Zahlen
Aus 36 Studien mit messbaren Effekten gezogen
Wahrscheinlich echte Effekte
83%
über Studien hinweg
Untersuchte Personen
3,370
typische Studie: 53 Personen
Stärkste Designs
30
6 gepoolt, 24 randomisiert
Zeigte Nutzen
92%
11/12 Studien
Wie lange Studien liefen
1–3 Monate
1
3+ Monate
1
Untersuchte Populationen
Women with premenstrual syndrome4
Women with PCOS2
Post-menopausal women2
Women with PMS1
Aktives Forschungsgebiet
20 Studien in den letzten 5 Jahren · Neueste Meta-Analyse: 2022
199820122026
1Premenstrual syndrome symptomsMeta-Analysen=1,878 · large study2019
Einfach gesagt: VAC preparations were confirmed to be effective in the reduction of PMS symptoms: women taking VAC were 2.57 (95% CI 1.52-4.35) times more likely to experience a remission in their symptoms compared to those taking the placebo.
Csupor D et al. · Complementary Therapies in Medicine (2019)
Vitex significantly reduced overall PMS symptom scores vs placebo
Most effective for irritability, mood swings, and breast tenderness
Standardized extracts (Ze 440 and BNO 1095) had strongest evidence
2Premenstrual symptomsSystematische Übersichtn=500 · large study2011
Einfach gesagt: However, more RCTs are required to account for the heterogeneity of the syndrome.
Dante G et al. · Journal of psychosomatic obstetrics and gynaecology (2011)
John's Wort show an effect different than placebo.
None of the herbs was associated with major health risks, although the reduced number of tested patients does not allow definitive conclusions on safety.
Some herb remedies seem useful for the treatment of PMS.
5Cyclic breast mastalgiaMeta-Analysen=20 · very small study2022
Einfach gesagt: Herbal medicines and their subgroups may have effective and helpful effects on improving cyclic breast mastalgia.
Mirzaee F et al. · Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia (2022)
Einfach gesagt: Therefore, native plants of Iran have been reported to have antimicrobial properties for the treatment of vaginal infections and can be used as a suitable and effective alternative to antibiotics in future research.
Rashidipour M et al. · Infectious disorders drug targets (2022)
Therefore, native plants of Iran have been reported to have antimicrobial properties for the treatment of vaginal infections and can be used as a suitable and effective alternative to antibiotics in future research.
7PCOS symptomsSystematische Übersichtn=15 · very small study2023
Einfach gesagt: Various studies have shown that herbal medicines can improve PCOS symptoms in women with minimal side effects but a longer treatment cycle.
Manouchehri A et al. · JBRA assisted reproduction (2023)
Various studies have shown that herbal medicines can improve PCOS symptoms in women with minimal side effects but a longer treatment cycle.
Einfach gesagt: A critical evaluation of the clinical data regarding the adverse effects has shown that herbal remedies are generally better tolerated than synthetic medications.
Izzo AA et al. · Phytotherapy research : PTR (2016)
A critical evaluation of the clinical data regarding the adverse effects has shown that herbal remedies are generally better tolerated than synthetic medications.
Nevertheless, potentially serious adverse events, including herb-drug interactions, have been described.
This suggests the need to be vigilant when using herbal remedies, particularly in specific conditions, such as during pregnancy and in the paediatric population.
9Depression and anxiety symptomsSystematische Übersicht2018
Einfach gesagt: However, well-designed larger clinical trials are needed before these herbs can be recommended and to further assess their psycho-oncologic relevance.
Yeung KS et al. · Phytotherapy research : PTR (2018)
Sehr groß Nutzen
← SchlechterKein EffektBesser →
Overall, 45% of studies reported positive findings with fewer adverse effects compared with conventional medications.
Based on available data, black cohosh, chamomile, chasteberry, lavender, passionflower, and saffron appear useful in mitigating anxiety or depression with favorable risk-benefit profiles compared to standard treatments.
These may benefit cancer patients by minimizing medication load and accompanying side effects.
11Premenstrual syndrome symptomsMeta-Analysen=17 · very small study2017
Einfach gesagt: Although meta-analysis shows a large pooled effect of Vitex agnus castus in placebo-controlled trials, the high risk of bias, high heterogeneity, and risk of publication bias of the included studies preclude a definitive conclusion.
Verkaik S et al. · American journal of obstetrics and gynecology (2017)
Sehr groß Nutzen
← SchlechterKein EffektBesser →
The pooled effect of Vitex agnus castus in placebo-controlled trials was large (Hedges g, -1.21; 95% confidence interval, -1.53 to -0.88), but heterogeneity was extremely high (I2, 91%).
Although meta-analysis shows a large pooled effect of Vitex agnus castus in placebo-controlled trials, the high risk of bias, high heterogeneity, and risk of publication bias of the included studies preclude a definitive conclusion.
The pooled treatment effects should be viewed as merely explorative and, at best, overestimating the real treatment effect of Vitex agnus castus for premenstrual syndrome symptoms.
12Treatment of oligomenorrhea and amenorrheaSystematische Übersichtn=12 · very small study2018
Einfach gesagt: Although just few plants have been proven to be effective for treatment of menstrual irregularities, the results and the classification in present study can be used as an outline for future studies and treatment.
Moini Jazani A et al. · BioMed research international (2018)
Einfach gesagt: Nevertheless, further high-quality studies are needed to firmly establish the biological and clinical efficacy of this plant.
Sirotkin AV. · Phytotherapy research : PTR (2025)
The main described target of Vitex agnus-castus is female reproduction.
It can up-regulate ovarian cycle and fecundity via a wide spectrum of mediators from hypothalamic, pituitary and ovarian hormones up to intracellular regulators of proliferation, apoptosis, oxidation and dopamine receptors.
Nevertheless, further high-quality studies are needed to firmly establish the biological and clinical efficacy of this plant.
16Premenstrual syndrome/premenstrual dysphoric disorder symptomsSystematische Übersichtn=19 · very small study2014
Einfach gesagt: Limited evidence supports the efficacy of alternative medicinal interventions such as acupuncture and herbal medicine in controlling premenstrual syndrome and premenstrual dysphoric disorder.
Jang SH et al. · BMC complementary and alternative medicine (2014)
Sehr groß Nutzen
← SchlechterKein EffektBesser →
Experimental groups with Acupuncture and herbal medicine treatment (all herbal medicine except Cirsium japonicum) had significantly improved results regarding PMS/PMDD.
Limited evidence supports the efficacy of alternative medicinal interventions such as acupuncture and herbal medicine in controlling premenstrual syndrome and premenstrual dysphoric disorder.
In both acupuncture and herbal medical interventions, there have been no serious adverse events reported, proving the safety of the interventions while most of the interventions provided over 50% relief of symptoms associated with PMS/PMDD.
Sopjani M et al. · Phytotherapy research : PTR (2026)
Emerging evidence from in vitro, in vivo, and clinical studies suggests that VAC may modulate key neuroendocrine pathways involved in menopause through dopaminergic, phytoestrogenic, opioidergic, and indirect serotonergic mechanisms.
These actions are proposed to influence prolactin regulation, estrogen receptor activity, mood stability, vasomotor symptoms, and overall hormonal balance during the menopausal transition.
This review synthesizes current knowledge on the phytochemical composition and mechanistic pathways of VAC relevant to menopausal symptom management, alongside an evaluation of its safety and clinical tolerability.
20Safety during pregnancy and lactationSystematische Übersicht2008
Einfach gesagt: Given its relatively common use amongst women of childbearing age, it is likely that some women may consume chastetree while unknowingly pregnant.
Dugoua JJ et al. · The Canadian journal of clinical pharmacology = Journal canadien de pharmacologie clinique (2008)
Given its relatively common use amongst women of childbearing age, it is likely that some women may consume chastetree while unknowingly pregnant.
Complementary and alternative medicine, midwifery and medical practitioners should be aware of this fact when prescribing chastetree to women of childbearing age, particularly when the patient is planning a family.