Avanafil (Stendra) and Vardenafil (Levitra): Can You Take Them Together?

Use caution — significant interaction

Avanafil (Stendra) and Vardenafil (Levitra) can interact. Additive hypotension, dizziness and syncope; a raised risk of priapism, and of a dangerous fall in blood pressure if a nitrate is ever needed acutely. Never combine. There is no additive benefit — switching between PDE5 inhibitors means stopping one before starting the other, and any change should go through the prescriber.

What the evidence says

majorconflict· limited evidence

Additive hypotension, dizziness and syncope; a raised risk of priapism, and of a dangerous fall in blood pressure if a nitrate is ever needed acutely.

Both are phosphodiesterase type 5 inhibitors. Taken together their vasodilatory effects are additive on the same enzyme, and both clear within several hours, so the overlap is same-day rather than prolonged — which lowers the duration of exposure, not the additive effect while it lasts.

What to do: Never combine. There is no additive benefit — switching between PDE5 inhibitors means stopping one before starting the other, and any change should go through the prescriber.

Avanafil (Stendra)

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Vardenafil (Levitra)

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Frequently asked questions

Can you take Avanafil (Stendra) and Vardenafil (Levitra) together?: Avanafil (Stendra) and Vardenafil (Levitra) can interact. Additive hypotension, dizziness and syncope; a raised risk of priapism, and of a dangerous fall in blood pressure if a nitrate is ever needed acutely. Never combine. There is no additive benefit — switching between PDE5 inhibitors means stopping one before starting the other, and any change should go through the prescriber.
Do Avanafil (Stendra) and Vardenafil (Levitra) interact?: Additive hypotension, dizziness and syncope; a raised risk of priapism, and of a dangerous fall in blood pressure if a nitrate is ever needed acutely. Both are phosphodiesterase type 5 inhibitors. Taken together their vasodilatory effects are additive on the same enzyme, and both clear within several hours, so the overlap is same-day rather than prolonged — which lowers the duration of exposure, not the additive effect while it lasts.
Should you separate Avanafil (Stendra) and Vardenafil (Levitra)?: Never combine. There is no additive benefit — switching between PDE5 inhibitors means stopping one before starting the other, and any change should go through the prescriber.

This information is for educational purposes only. It is not a substitute for professional medical advice. Always consult a qualified healthcare provider before starting, stopping, or changing any supplement or medication.

What the evidence says

majorconflict· limited evidence

Additive hypotension, dizziness and syncope; a raised risk of priapism, and of a dangerous fall in blood pressure if a nitrate is ever needed acutely.

What to do: Never combine. There is no additive benefit — switching between PDE5 inhibitors means stopping one before starting the other, and any change should go through the prescriber.

Frequently asked questions

Can you take Avanafil (Stendra) and Vardenafil (Levitra) together?

Do Avanafil (Stendra) and Vardenafil (Levitra) interact?

Additive hypotension, dizziness and syncope; a raised risk of priapism, and of a dangerous fall in blood pressure if a nitrate is ever needed acutely. Both are phosphodiesterase type 5 inhibitors. Taken together their vasodilatory effects are additive on the same enzyme, and both clear within several hours, so the overlap is same-day rather than prolonged — which lowers the duration of exposure, not the additive effect while it lasts.

Should you separate Avanafil (Stendra) and Vardenafil (Levitra)?

Never combine. There is no additive benefit — switching between PDE5 inhibitors means stopping one before starting the other, and any change should go through the prescriber.