Vitamin B12 and Vitamin C: Can You Take Them Together?

Notable interaction — adjust timing

Vitamin B12 and Vitamin C can interact. Potentially reduced B12 effectiveness at very high vitamin C doses Separate high-dose vitamin C (>1000mg) from B12 by 2+ hours.

What the evidence says

minorconflict· limited evidence

Potentially reduced B12 effectiveness at very high vitamin C doses

High-dose vitamin C may destroy vitamin B12 (controversial mechanism)

What to do: Separate high-dose vitamin C (>1000mg) from B12 by 2+ hours.

Vitamin B12

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Vitamin C

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Compare Vitamin B12 vs Vitamin C Check your full stack

Related interactions

Methylfolate & Vitamin B12 Multivitamin & Vitamin B12 Iron & Vitamin C Vitamin C & Vitamin E Quercetin & Vitamin C Calcium & Vitamin C

Frequently asked questions

Can you take Vitamin B12 and Vitamin C together?: Vitamin B12 and Vitamin C can interact. Potentially reduced B12 effectiveness at very high vitamin C doses Separate high-dose vitamin C (>1000mg) from B12 by 2+ hours.
Do Vitamin B12 and Vitamin C interact?: Potentially reduced B12 effectiveness at very high vitamin C doses High-dose vitamin C may destroy vitamin B12 (controversial mechanism)
Should you separate Vitamin B12 and Vitamin C?: Separate high-dose vitamin C (>1000mg) from B12 by 2+ hours.

This information is for educational purposes only. It is not a substitute for professional medical advice. Always consult a qualified healthcare provider before starting, stopping, or changing any supplement or medication.