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Htp5.5
5-HTP – Forschung
Hilft wahrscheinlich
54 begutachtete Studien
Was die Evidenz sagt
Hilft wahrscheinlich
5-HTP scheint in 5 von 5 Studien mit messbaren Effekten zu helfen — die Evidenz tendiert klar ins Positive.
Die meiste Evidenz stammt aus hochwertigen Meta-Analysen und randomisierten Studien, veröffentlicht 1983–2026 mit einer typischen Studiengröße von 18 Teilnehmenden.
Basierend auf 54 Studien · 2 Meta-Analysen · 41 RCTs · 4,864 Teilnehmende insgesamt
Konfidenz
Hohe Konfidenz
Was die Studien gefunden haben
5geholfen· 49 weitere ohne bewertete Effektdaten
Nach Outcome
Depression & moodKann die Stimmung verbessern und leichte depressive Symptome reduzieren · 2-4 weeks
Sleep & insomniaKann die Schlafqualität über den Serotonin-/Melatonin-Stoffwechselweg verbessern · 1-2 weeks · Verbesserte Schlafqualität durch Umwandlung von Serotonin zu Melatonin · 2-4 weeks · Moderate Verbesserung der Schlafkontinuität durch Serotonin-Unterstützung · 2-4 weeks
Überwiegend Mechanismus / Beobachtung5 Studien
Migraine & headache
Überwiegend Mechanismus / Beobachtung4 Studien
Weight management
Überwiegend Mechanismus / Beobachtung4 Studien
Women's health
Überwiegend Mechanismus / Beobachtung4 Studien
Cognitive function
Überwiegend Mechanismus / Beobachtung3 Studien
In Zahlen
Aus 17 Studien mit messbaren Effekten gezogen
Wahrscheinlich echte Effekte
75%
über Studien hinweg
Untersuchte Personen
4,864
typische Studie: 18 Personen
Stärkste Designs
43
2 gepoolt, 41 randomisiert
Zeigte Nutzen
100%
5/5 Studien
Wie lange Studien liefen
1–3 Monate
3
Untersuchte Populationen
Healthy subjects2
Universal PTSD prevention populations1
Adults with fibromyalgia1
Review1
Stetige Forschung
10 Studien in den letzten 5 Jahren · Neueste Meta-Analyse: 2020
198320042026
1Systematische Übersichtn=2,023 · very large study2022
Einfach gesagt: This review provides uncertain evidence only regarding the use of hydrocortisone, propranolol, dexamethasone, omega-3 fatty acids, gabapentin, paroxetine, PulmoCare formula, Oxepa formula, or 5-hydroxytryptophan as universal PTSD prevention strategies.
Bertolini F et al. · The Cochrane database of systematic reviews (2022)
This review provides uncertain evidence only regarding the use of hydrocortisone, propranolol, dexamethasone, omega-3 fatty acids, gabapentin, paroxetine, PulmoCare formula, Oxepa formula, or 5-hydroxytryptophan as universal PTSD prevention strategies.
Future research might benefit from larger samples, better reporting of side effects and inclusion of quality of life and functioning measures.
Einfach gesagt: There are few, large, high-quality trials comparing combination pharmacotherapy with monotherapy for fibromyalgia, consequently limiting evidence to support or refute the use of combination pharmacotherapy for fibromyalgia.
Thorpe J et al. · The Cochrane database of systematic reviews (2018)
Two studies only reported any primary outcomes of interest (patient-reported pain relief of 30%, or 50%, or greater).
There are few, large, high-quality trials comparing combination pharmacotherapy with monotherapy for fibromyalgia, consequently limiting evidence to support or refute the use of combination pharmacotherapy for fibromyalgia.
4Narrative review of 5-HTP physiology and clinical useÜbersicht2020
Einfach gesagt: The physiological role of 5-HTP in the treatment of depression, anxiety, panic, sleep disorders, obesity, myoclonus and serotonin syndrome are also discussed.
Maffei ME · International journal of molecular sciences (2020)
Decarboxylation of 5-HTP yields serotonin (5-hydroxytryptamine, 5-HT) that is further transformed to melatonin (N-acetyl-5-methoxytryptamine).
5-HTP plays a major role both in neurologic and metabolic diseases and its synthesis from tryptophan represents the limiting step in serotonin and melatonin biosynthesis.
5-HTP toxicity and the occurrence of toxic impurities present in tryptophan and 5-HTP preparations are also discussed.
5Alcohol use disorder treatment effectivenessSystematische Übersicht2018
Einfach gesagt: No significant benefit for the use of combinations over single agents was observed.
Naglich AC et al. · CNS drugs (2018)
Drug combination effect sizes were comparable to those observed in single-agent trials.
No significant benefit for the use of combinations over single agents was observed.
However, benefit may be observed when combined pharmacological interventions address specific symptoms of alcohol use disorder known to be influenced by combination components, or when combinations are used in specific subpopulations in which combination components demonstrate benefit.
13Cognitive function (MoCA score)RCTn=30 · small study2025
Einfach gesagt: However, given the relatively small sample size (n = 30) and short-term (12-week) intervention, these findings should be interpreted cautiously, and further long-term studies with a larger sample size are warranted to confirm these preliminary results.
Li S et al. · Nutrients (2025)
Spürbar Nutzen
← SchlechterKein EffektBesser →
Borderline
Results: A significant time effect was observed in the MoCA score, which was mainly explained by a significant increase in the 5-HTP group (week 0 vs. week 12: 26.6 ± 1.4 a.u. vs. 27.6 ± 1.4 a.u., p < 0.05).
Moreover, the 5-HTP group showed a significant increase in serum serotonin levels.
Additionally, the GDS score improved in the 5-HTP group (week 0 vs. week 8: 1.2 ± 1.7 a.u. vs. 0.7 ± 1.2 a.u., p < 0.05).