40 peer-reviewed studies · Evidence score: 7/10
Paley EL • Journal of Alzheimer's disease : JAD (2019)
ADAS is attributable to potentially modifiable risk factors of AD associated diseases.
Manole OM et al. • Medical sciences (Basel, Switzerland) (2025)
The effects exerted by AG depend on the dose and route of administration, as well as on the receptors involved and the pathophysiological pathway used.
Pretorius L et al. • Molecular medicine (Cambridge, Mass.) (2025)
This systematic-review examined the effects of Agmatine.
Kouba BR et al. • Cells (2024)
Further studies are necessary to explore the therapeutic benefits of these alternative therapies for MDD.
Rafi H et al. • Neuropeptides (2024)
The safety and efficacy of agmatine supplementation, demonstrated through various animal and human studies, affirm its potential as a beneficial therapeutic agent.
Nangia A et al. • Naunyn-Schmiedeberg's archives of pharmacology (2024)
The present review explores the evidences and available data on possible uses of metformin/agmatine as pertinent antidiabetic and antiepileptic agents.
Rafe MR et al. • Behavioural brain research (2024)
Given the unique expression of different subunits of the well-organized NMDA receptor system by neurons.
Moretti M et al. • Frontiers in bioscience (Elite edition) (2014)
Moreover, some molecular mechanisms underlying the neuroprotective effects of agmatine will be discussed.
Uzbay TI • Neuroscience and biobehavioral reviews (2012)
Interactions between agmatine and other central neurotransmitter systems, such as the glutamatergic and nitrergic systems, are also very important.
Moriyama Y et al. • Biochimica et biophysica acta. Biomembranes (2020)
SLC18B1 gene knockout decreased polyamine levels by ~20% in the brain, and impaired short- and long-term memory.
Akasaka N et al. • Amino acids (2020)
We also briefly discuss agmatine content in foodstuffs, and a simple approach for enhancing agmatine production using the filamentous fungus Aspergillus oryzae, widely used for the production of various Asian fermented foods.
Luengo JM et al. • Environmental microbiology (2020)
Knowledge of these pathways has allowed the design and collection of genetically manipulated microbes useful for eliminating BAs from different sources, highlighting the biotechnological applications of these studies.
Wang W et al. • Journal of agricultural and food chemistry (2020)
We believe that the studies on phenolamides are still in the infancy stage and additional health benefits of these phenolamides may yet be identified.
Kotagale NR et al. • Neurotoxicology (2019)
However, it will be hasty to assert and promote agmatine as a novel therapeutic agent for neuroprotection.
Barua S et al. • Neurochemical research (2019)
In this review, we will focus on the pathophysiological aspects of the neurological disorders regulated by these ion channels and receptors, and their interaction with agmatine in CNS injury.
Xu W et al. • Current neuropharmacology (2018)
The safety and low incidence of adverse effects indicate the vast potential therapeutic value of agmatine in the treatment of neurological diseases.
Benítez J et al. • Metabolism: clinical and experimental (2018)
In rat brain, agmatine, AGM and ALP are predominantly localised in areas associated with roles in appetitive and craving (drug-reinstatement) behaviors.
Lenis YY et al. • Zygote (Cambridge, England) (2017)
In this paper the main concepts on the history, structure and molecular pathways of polyamines as well as their physiological role on angiogenesis, and reproductive physiology are reviewed.
Neis VB et al. • Neurochemistry international (2017)
Agmatine also stimulates the expression of trophic factors and adult neurogenesis, contributing to its ability to induce endogenous repair mechanisms.
Monné M et al. • Amino acids (2015)
Ort1p is involved in the biosynthesis of arginine and polyamines in yeast.