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Benfotiamine (Fat-Soluble Vitamin B1)
Fat-soluble form of vitamin B1 with superior absorption that protects against glycation and supports nerve health.
What the evidence says
Benfotiamine appears to help in 7 of 7 studies with measurable effects — the evidence leans clearly favourable.
Most evidence is from high-quality meta-analyses and randomised trials published 2003–2023 with a typical study size of 39 participants.
Based on 37 studies · 2 meta-analyses · 21 RCTs · 3,508 total participants
Confidence
HighWhat the studies found
By outcome
Benfotiamine has an evidence score of 8.5/10 — very strong evidence based on 37 indexed studies, including 2 meta-analyses. Fat-soluble form of vitamin B1 with superior absorption that protects against glycation and supports nerve health.
The commonly studied dose of Benfotiamine is 150-600mg daily. Research points to an estimated optimal dose around 450mg, with a minimum effective dose near 300mg. Individual response varies — start low and adjust.
The best time to take Benfotiamine is with meals. Take it with food. Benfotiamine is a lipid-soluble synthetic derivative of thiamine (vitamin B1).
Last reviewed May 2026 · evidence from 37 studies · how we score
This information is for educational purposes only. It is not a substitute for professional medical advice. Always consult a qualified healthcare provider before starting, stopping, or changing any supplement or medication.
Benfotiamine is a synthetic, fat-soluble derivative of thiamine (B1) with 5x greater bioavailability. It reduces advanced glycation end-products (AGEs) that damage nerves and blood vessels in diabetes. Used clinically for diabetic neuropathy and increasingly for anyone concerned about blood sugar, nerve health, or alcohol-related B1 depletion.
Blocks formation of damaging glycation products
Protects nerve cells from glucose damage
How Benfotiamine works — from molecular targets to health outcomes. Click an edge to see supporting research.This visualization is in beta — pathways are being refined and expanded.
150-600mg daily
Take with food
| Form | Type |
|---|---|
| 💊Benfotiamine capsules | Recommended |
| 💊Combined with other B vitamins | Alternative |
Often combined with alpha-lipoic acid for enhanced neuropathy support.
Minimum: 6 weeks
Optimal: 12 weeks
Cycling: Not required
Note: Fat-soluble — take with food containing fat for best absorption.
Limited RCT data with mixed results. Meta-analysis found insufficient evidence to determine clear benefit. Conservative estimates based on subset of positive trials showing modest improvements in neuropathic symptoms.
Reduced numbness, tingling, pain
Lower glycation markers
Commonly used; may help with neuropathy
Thiamine may interfere with this cancer drug
Tip: Take with food
Benfotiamine is generally well-tolerated and considered safe for most healthy adults at recommended doses. The most commonly reported side effects are GI upset. Use caution if any of these apply to you: Known allergy or hypersensitivity to Benfotiamine or related compounds.
Alpha Lipoic Acid
Likely helpsUniversal antioxidant that works in both water and fat, supporting blood sugar control, nerve health, and cellular energy.
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