Best Supplements to Reduce Inflammation

Lipid-soluble antioxidant that shields cell membranes from oxidative damage — natural mixed tocopherols preferred over synthetic forms.

Drops CRP by ~0.6 mg/L· Strong evidence

Odorless garlic extract with strong evidence for cardiovascular health, blood pressure, and immune support.

Drops CRP by ~1.4 mg/L· Moderate evidence

Rich source of oligomeric proanthocyanidins (OPCs) that support circulation, skin health, and antioxidant defense.

Cuts CRP by ~0.7 mg/L· Moderate evidence

Citrus flavonoid that strengthens blood vessel integrity — well-studied for chronic venous insufficiency, blood pressure, and inflammation.

Cuts CRP by ~0.7 mg/L· Moderate evidence

Prebiotic fiber that selectively feeds Bifidobacteria and Lactobacilli, producing short-chain fatty acids for gut health and immunity.

Cuts CRP by ~0.6 mg/L· Moderate evidence

Enhances insulin signaling to improve glucose uptake into cells — helps regulate blood sugar and reduce carbohydrate cravings.

Drops CRP by ~0.4 mg/L· Moderate evidence

Plant compounds with weak estrogenic effects that support menopausal symptoms, bone health, and cardiovascular function.

Cuts CRP by ~0.4 mg/L· Moderate evidence

Proanthocyanidin-rich extract that improves blood flow, skin elasticity, and cognitive function — backed by 160+ published studies.

Cuts CRP by ~20 mg/L· Weak evidence

Oleuropein-rich extract with antiviral, antibacterial, and blood pressure-lowering effects — part of the Mediterranean diet's protective profile.

Reduce CRP by ~15.7 mg/L· Weak evidence

Live microorganisms where strain selection determines outcome — Lactobacillus and Bifidobacterium strains best studied for gut, immune, and mood.

Reduce CRP by ~12.6 mg/L· Weak evidence