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5 peer-reviewed studies
What the evidence says
Most Butcher's Broom studies are mechanism or observational rather than RCTs that measure a clinical effect — keep findings provisional.
Most evidence is from medium-quality meta-analyses and randomised trials published 2002–2025 with a typical study size of 148 participants.
Based on 5 studies · 1 meta-analysis · 1 RCT · 148 total participants
Confidence
ModerateBy outcome
2 studies in the last 5 years · Latest meta-analysis: 2003
A meta-analysis of 25 randomized trials of Cyclo 3 Fort (Ruscus + hesperidin methyl chalcone + ascorbic acid) found reduced chronic-venous-insufficiency symptoms and severity.
Boyle P et al. · Int Angiol (2003)
A multicenter, double-blind RCT found Ruscus aculeatus extract (monotherapy) significantly reduced lower-leg edema versus placebo in women with chronic venous insufficiency.
Vanscheidt W et al. · Arzneimittelforschung (2002)
A comprehensive review summarized the venoconstrictive and microcirculatory effects of Ruscus extract combined with hesperidin methyl chalcone and ascorbic acid.
Allaert FA et al. · Int Angiol (2016)
A 2025 review of venoactive compounds for chronic venous disease included Ruscus among recommended options.
Gloviczki ML et al. · J Vasc Surg Venous Lymphat Disord (2025)
A 2024 update on herbal drugs for chronic venous disease covered Ruscus aculeatus among evidence-supported botanicals.
Bencsik T et al. · Fitoterapia (2024)