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Cak3.5
Calcium AKG – Forschung
Hilft wahrscheinlich
24 begutachtete Studien
Was die Evidenz sagt
Hilft wahrscheinlich
Calcium AKG scheint in 4 von 5 Studien mit messbaren Effekten zu helfen — die Evidenz tendiert klar ins Positive.
Die meiste Evidenz stammt aus hochwertigen randomisierten Studien, veröffentlicht 1999–2026 mit einer typischen Studiengröße von 40 Teilnehmenden.
Basierend auf 24 Studien · 14 RCTs · 731 Teilnehmende insgesamt
Konfidenz
Mittlere Konfidenz
Was die Studien gefunden haben
4geholfen1unklar· 19 weitere ohne bewertete Effektdaten
Nach Outcome
Longevity & agingLebensdauervorteile nur im Tiermodell gezeigt; keine abgeschlossenen Endpunkte am Menschen · 4-6 months
Hilft wahrscheinlich14 Studien
Muscle strength & power
Überwiegend Mechanismus / Beobachtung7 Studien
Endurance & exercise performance
Überwiegend Mechanismus / Beobachtung6 Studien
Cognitive function
Überwiegend Mechanismus / Beobachtung4 Studien
Therapeutic & clinical
Überwiegend Mechanismus / Beobachtung3 Studien
Safety profile
Überwiegend Mechanismus / Beobachtung3 Studien
Bone health
Zu wenige bewertete Studien2 Studien
Lean body mass & muscle growth
Zu wenige bewertete Studien2 Studien
Heart & blood pressure
Zu wenige bewertete Studien2 Studien
Inflammation
Zu wenige bewertete Studien2 Studien
Recovery
Zu wenige bewertete Studien1 Studie
Energy & fatigueNur mechanistische Rolle; keine Energie-Endpunkte am Menschen · 4-8 weeks
Zu wenige bewertete Studien1 Studie
Glucose & metabolicMechanistische Rolle im Citratzyklus; keine metabolischen Endpunkte am Menschen · 8-12 weeks
Zu wenige bewertete Studien1 Studie
Neuroprotection & brain aging
Zu wenige bewertete Studien1 Studie
Women's health
Zu wenige bewertete Studien1 Studie
In Zahlen
Aus 19 Studien mit messbaren Effekten gezogen
Wahrscheinlich echte Effekte
100%
über Studien hinweg
Untersuchte Personen
731
typische Studie: 40 Personen
Stärkste Designs
14
0 gepoolt, 14 randomisiert
Zeigte Nutzen
80%
4/5 Studien
Wie lange Studien liefen
Unter einer Woche
1
1–3 Monate
1
3+ Monate
3
Untersuchte Populationen
metabolic syndrome patients1
middle-aged adults1
Biologically older, middle-aged adults1
Patients with hepatic encephalopathy1
Aktives Forschungsgebiet
12 Studien in den letzten 5 Jahren
199920122026
1metabolic syndrome parametersÜbersicht2024
Einfach gesagt: For the next step, researchers may focus on the co-pathogenesis of metabolic syndrome and investigate whether α-KG can be used to achieve the therapeutic goal of "homotherapy for heteropathy" in the treatment of metabolic syndrome.
Li Y, Wang Y, Yuan Q. · Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition (2024)
Exogenous supplementation of α-KG improves obesity, blood glucose levels, and cardiovascular disease risks associated with metabolic syndrome.
Furthermore, α-KG regulates the common pathological mechanisms of metabolic syndrome, suggesting the potential application prospect of α-KG in metabolic syndrome.
For the next step, researchers may focus on the co-pathogenesis of metabolic syndrome and investigate whether α-KG can be used to achieve the therapeutic goal of "homotherapy for heteropathy" in the treatment of metabolic syndrome.
Einfach gesagt: This review aims to provide a comprehensive overview of AKG's benefits and identify future directions for research in both clinical and sports settings.
Xu M, Zhang Q, Liu X, Lu L, Li Z. · Nutrients (2024)
For athletes and active individuals, AKG supplementation has enhanced endurance, reduced fatigue, and supported faster post-exercise recovery.
Despite promising preliminary findings, research gaps remain in understanding AKG's long-term effects, optimal dosage, and specific pathways, particularly across diverse populations.
Further research, including large-scale clinical trials, is essential to clarify AKG's role in muscle health and to optimize its application as a therapeutic agent for skeletal muscle diseases and an enhancer of physical performance.
3biological aging markersRCTn=42 · small study2024
Einfach gesagt: Provides direct human RCT evidence for calcium AKG's potential to reduce biological aging markers, central to its longevity supplement claims.
Shahmirzadi AA et al. · Cell Reports Medicine (2024)
Spürbar Nutzen
← SchlechterKein EffektBesser →
Calcium AKG supplementation reduced epigenetic age by approximately 7 years versus placebo on DNAmPhenoAge clock
Inflammatory biomarkers including IL-6 and CRP showed favorable reductions in the treatment group
Supplementation was well tolerated with no serious adverse events reported
4Recruitment feasibilityRCTn=120 · medium study2025
Einfach gesagt: ABLE demonstrated the feasibility of recruiting biologically older yet generally healthy middle-aged adults for gerotherapeutic interventions.
Lim ZM et al. · Experimental gerontology (2025)
Kein klarer Effekt
← SchlechterKein EffektBesser →
Eligibility rates were 80.3 % at pre-screening and 67.3 % at screening, with a consent rate of 66.1 %.
Conversion rates were 25.7 % and 48.4 % from pre-screening and screening to enrolment, respectively.
The biological age was exceeding the chronological age in 80.2 % of participants and 54.3 % reported no pre-existing health conditions.
6Brain perfusion improvementRCTn=27 · very small study2018
Einfach gesagt: Isoleucine supplementation achieved a better impact on brain perfusion restoration in HE.
Romeiro FG et al. · NeuroImage. Clinical (2018)
Likely real
Brain single Photon Emission Computed Tomography (SPECT) and dynamic brain scintigraphy (DBS) were performed pretreatment and at 1, 8 and 12 months of supplementation.
Brain perfusion was increased only in the isoleucine group at 8 months of treatment by both SPECT and DBS (p < 0.001 and p = 0.05, respectively) and by SPECT at the 12th month (p < 0.05).
This was associated with hepatic encephalopathy improvement at 8 and 12 months (p = 0.008 and 0.004, respectively), which was not observed in the leucine group (p = 0.313 and 0.055, respectively).
Einfach gesagt: The results of this study indicate that the daily co-supplementation with calcium salt of β-hydroxy-β-methylbutyrate (7.5 g) and L-Arginine α-ketoglutarate (10 g) during training might help to prevent decline in jump performance.
Kaczka P et al. · Nutrients (2021)
Likely real
At the end of the training cycle, a significant (p = 0.002) decrease in the countermovement jump (CMJ) height was found in the placebo group when compared to the baseline.
In contrast to the supplements group, in the placebo group, the CMJ changes were statistically significant: a noticeable (p = 0.002) decrease in CMJ was noted between the baseline measurement and the 6th measurement.
The well-being of the subjects from both groups changed significantly during the training period, and the intergroup differences in the mood level were similar and not statistically significant.
8Bench press performanceCrossovern=15 · very small study2022
Einfach gesagt: These results indicate that MIPS supplementation is less ergogenic and cost effective than caffeine alone.
Kruszewski M et al. · Nutrients (2022)
In a cross-over manner, they participated in two sessions where they were blinded to the order of supplementation they were given: either a MIPS including caffeine or caffeine alone.
They completed the bench press strength endurance test with pre- and post-training psychological assessments containing FS, FAS and sRPE.
Bench press repetition volume was greater after anhydrous caffeine than MIPS supplementation with no difference in psychological measures.
9Shoulder post-operative pain and repair integrityRCTn=90 · small study2012
Einfach gesagt: The use of the supplement for 3 months after cuff repair decreases shoulder post-operative pain and leads to a slight improvement in repair integrity.
Gumina S et al. · Current medical research and opinion (2012)
No statistically significant differences were identified between the two groups for each considered variable, except for shoulder pain (follow-up: 6 months) and repair integrity (final follow-up).
Analogously, in Group I, the percentage of patients with a better repair integrity result was significantly higher than Group II.
The use of the supplement for 3 months after cuff repair decreases shoulder post-operative pain and leads to a slight improvement in repair integrity.
Einfach gesagt: Because AAKG supplementation may hinder muscular endurance, the use of these supplements before resistance training should be questioned.
Greer BK et al. · Journal of strength and conditioning research (2011)
The AAKG supplementation did not improve muscle endurance or significantly affect the BP response to anaerobic work.
Subjects performed fewer total chin-ups (23.75 ± 6.38 vs. 25.58 ± 7.18) and total trial repetitions (137.92 ± 28.18 vs. 141.08 ± 28.57) in the supplement trial (p ≤ 0.05).
Subjects executed fewer reverse chin-ups (5.83 ± 1.85 vs. 6.75 ± 2.09) during set 2 after receiving the supplement as compared to the placebo (p < 0.05).
Einfach gesagt: Within the confines of this study, ingestion of PWS and/or PWS + S prior to exercise appears to be well-tolerated when consumed by young, healthy individuals.
Jung YP et al. · Journal of the International Society of Sports Nutrition (2017)
No statistically significant differences were observed among treatments in total bench press lifting volume, leg press lifting volume or WAC sprint performance.
Within the confines of this study, ingestion of PWS and/or PWS + S prior to exercise appears to be well-tolerated when consumed by young, healthy individuals.
The primary effects appear to be to increase REE responses and improve perceptions about readiness to perform and cognitive function with limited to no effects on muscular endurance and WAC.
Einfach gesagt: Results provide some evidence that 4-weeks of PWS and/or PWS + S supplementation can improve some indices of cognitive function and exercise performance during resistance-training without significant side effects in apparently health males.
Jung YP et al. · Journal of the International Society of Sports Nutrition (2017)
Although significant time effects were seen, no statistically significant overall MANOVA Wilks' Lambda interactions were observed among groups for body composition, resting heart and blood pressure, readiness to perform questions, 1RM strength, anaerobic sprint capacity, or blood chemistry panels.
MANOVA univariate analysis and analysis of changes from baseline with 95% CI revealed some evidence that cognitive function and 1RM strength were increased to a greater degree in the PWS and/or PWS + S groups after 4- and/or 8-weeks compared to PLA responses.
Results provide some evidence that 4-weeks of PWS and/or PWS + S supplementation can improve some indices of cognitive function and exercise performance during resistance-training without significant side effects in apparently health males.
13Plasma L-arginine levelsRCTn=24 · very small study2011
Einfach gesagt: NO(2) Platinum increased plasma L-arginine levels; however, the effects observed in hemodynamics, brachial-artery blood flow, and NOx can only be attributed to the resistance exercise.
Willoughby DS et al. · International journal of sport nutrition and exercise metabolism (2011)
NO(2) Platinum increased plasma L-arginine levels; however, the effects observed in hemodynamics, brachial-artery blood flow, and NOx can only be attributed to the resistance exercise.
Einfach gesagt: This systematic-review examined the effects of Calcium AKG.
Wei F, Liu Z, Yu X, Sun Y, Zhao Y, Wang Y, Feng Z, Zhao X, Ke X, Yang A, Cui H. · Autophagy (2026)
Dysregulation of this network contributes broadly to human diseases including inflammatory bowel disease, cancer, and neurodegenerative disorders.
Notably, the functional impact of specific regulatory events is highly context dependent, a principle exemplified by the Crohn disease-associated T300A polymorphism.
Deciphering this regulatory landscape and its crosstalk with both autophagy-dependent and autophagy-independent functions positions ATG16L1 as a pivotal node in cellular homeostasis and as an emerging therapeutic target.
Einfach gesagt: This clinical trial supports a potential benefit of OKG 10g daily in the subgroup of patients with pressure ulcers <or= 8 cm2 surface area in elderly population when associated with debridement together with wound management according to pressure ulcer guidelines.
Meaume S et al. · The journal of nutrition, health & aging (2009)
Spürbar Nutzen
← SchlechterKein EffektBesser →
Likely real
At inclusion, ulcer area distribution deviated from normal distribution (median ulcer area OKG 6.6 cm(2), placebo 3.9 cm2, p=0.044, Mann-Whitney test).
The mean wound area reduction for baseline area <or= 8 cm2 are -59.5 +/- 71.4% and -54.0 +/- 69.0% for the OKG group and placebo groups respectively (p=0.477, Mann-Whitney test).
When closure rate is considered, a significant difference in favor of OKG group is observed (- 0.07 cm2/day in the OKG group and - 0.04 cm2/day in the placebo groups respectively p=0.007, Mann-Whitney test).
16Metabolic and immunomodulatory effectsSystematische Übersicht2026
Einfach gesagt: All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.
Niederegger T et al. · Journal of burn care & research : official publication of the American Burn Association (2026)
For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints.
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Einfach gesagt: Therefore, alpha-ketoglutarate is linked to improving reproductive performance, but further studies are needed due to a lack of studies on humans.
Doroftei B, Ilie OD, Timofeiov S, Dabuleanu AM, Scripcariu IS, Micu R, Tataranu E. · Reproduction (Cambridge, England) (2024)
This metabolite modulates the expression of pluripotency genes, thus controlling stem cells' self-renewal, differentiation, and reprogramming dynamics, while also alleviating structural transformations induced by exposure to heavy metals and other inhibitors.
This significantly demonstrated a direct influence of alpha-ketoglutarate in mitigating oxidative stress and prolonging the lifespan, consequently supporting metabolic and endocrine adjustments.
It influences oocyte quality and quantity, delays reproductive aging, and establishes an optimal competence framework for development with minimal risk of failure.
This review systematically proposes an integrated theoretical framework of "aging metabolic memory", explaining the persistence, transmissibility, and potential heritability of aging from a systems biology perspective.
This review summarizes the spatiotemporal dynamic characteristics of aging and may provide multi-dimensional intervention pathways for the precise prevention and treatment of age-related diseases and the promotion of healthy aging.
19Calcium AKG efficacy on osteoclast regulationÜbersicht2026
Einfach gesagt: Elucidating these pathways will reshape our understanding of osteoclast regulation and help identify new metabolic targets for treating bone diseases.
Chandrasekaran K et al. · Current osteoporosis reports (2026)
Einfach gesagt: The goal of this review is to critically examine the current mechanistic knowledge related to AKG biosynthesis and breakdown and its future implications in maintaining cellular homeostasis and controlling chronic inflammation.
Devulapalli V, Sathiyamurthi A, Gautam S, Bhattaram P. · Biomedicines (2026)
Additionally, because endogenous AKG levels decrease with age, oral supplementation of AKG, especially with calcium and arginine, has drawn attention to its potential benefits in longevity and metabolic health.
Thus, AKG is versatile and has encouraging therapeutic promise for cancer, aging, and inflammatory illnesses.
However, a lack of human clinical evidence prompts further research to determine ideal dosage, tissue selectivity, and long-term safety.