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Calcium Alpha-Ketoglutarate
Emerging longevity compound that may reduce biological age markers, support cellular energy, and extend healthspan.
What the evidence says
Calcium AKG appears to help in 3 of 4 studies with measurable effects — the evidence leans clearly favourable.
Most evidence is from high-quality randomised trials published 2006–2026 with a typical study size of 40 participants.
Based on 18 studies · 13 RCTs · 731 total participants
Confidence
ModerateWhat the studies found
By outcome
Calcium AKG has an evidence score of 8.5/10 — very strong evidence based on 18 indexed studies, including 4 meta-analyses. Emerging longevity compound that may reduce biological age markers, support cellular energy, and extend healthspan.
The commonly studied dose of Calcium AKG is 1000-2000mg. Research points to an estimated optimal dose around 2000mg, with a minimum effective dose near 1000mg. Individual response varies — start low and adjust.
The best time to take Calcium AKG is in the morning. Taking it with food is preferred. Calcium alpha-ketoglutarate (Ca-AKG) is a Krebs cycle intermediate combined with calcium.
Last reviewed May 2026 · evidence from 33 studies · how we score
This information is for educational purposes only. It is not a substitute for professional medical advice. Always consult a qualified healthcare provider before starting, stopping, or changing any supplement or medication.
Calcium Alpha-Ketoglutarate (Ca-AKG) is a salt of alpha-ketoglutarate, a key metabolite in the Krebs cycle. Recent research shows it extends lifespan in animal models and reduces biological age markers in humans. It plays roles in energy metabolism, collagen synthesis, and epigenetic regulation. Gaining attention as a promising longevity intervention.
Key metabolite in cellular energy production
May affect DNA methylation and aging markers
Cofactor for collagen production
How Calcium AKG works — from molecular targets to health outcomes. Click an edge to see supporting research.This visualization is in beta — pathways are being refined and expanded.
1000-2000mg
Can be taken without food
| Form | Type |
|---|---|
| 💊Calcium alpha-ketoglutarate powder or capsules | Recommended |
| 💊AAKG (arginine AKG — different compound) | Alternative |
Calcium AKG is the form used in longevity research. AAKG is different and used for nitric oxide.
Minimum: 12 weeks
Optimal: 24 weeks
Cycling: Not required
Note: Can be taken any time. Some prefer morning.
Based on single RCT (n=40) showing prevention of performance decline in track athletes. Effect was prevention of countermovement jump height decrease rather than enhancement. Limited evidence from one small study.
Lower epigenetic age markers
Supported cellular energy
Insufficient data; avoid
Generally well-tolerated
Tip: Take with food
Calcium AKG is generally well-tolerated and considered safe for most healthy adults at recommended doses. The most commonly reported side effects are GI upset. Use caution if any of these apply to you: Known allergy or hypersensitivity to Calcium AKG or related compounds.
Urolithin A
Likely helpsPostbiotic that triggers mitophagy — the cleanup of damaged mitochondria — to support muscle health and cellular energy.
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