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3 peer-reviewed studies
What the evidence says
Most Calcium-D-Glucarate studies are mechanism or observational rather than RCTs that measure a clinical effect — keep findings provisional.
Most evidence is from medium-quality studies published 1989–2002.
Based on 3 studies
Confidence
Very lowBy outcome
Newest study from 2002
An animal study found calcium glucarate reduced beta-glucuronidase activity and showed anti-carcinogenic effects.
Dwivedi C et al. · Biochem Med Metab Biol (1990)
A review summarized calcium-D-glucarate and its proposed beta-glucuronidase-inhibiting, detoxification-supporting role.
· Altern Med Rev (2002)
An animal study examined D-glucaro-1,4-lactone (the active metabolite) excretion and beta-glucuronidase inhibition.
Macfadyen A et al. · Hepatology (1989)