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Calcium-D-Glucarate
A calcium salt of glucaric acid that inhibits beta-glucuronidase (an enzyme that recycles toxins and estrogens back into circulation) — a plausible 'detox/estrogen-clearance' mechanism, but the evidence is essentially all preclinical with NO human efficacy trials.
What the evidence says
Most Calcium-D-Glucarate studies are mechanism or observational rather than RCTs that measure a clinical effect — keep findings provisional.
Most evidence is from medium-quality studies published 1989–2002.
Based on 3 studies
Confidence
Very low confidenceBy outcome
Only a plausible beta-glucuronidase-inhibition mechanism from animal and review studies supports it; with no human efficacy trials for detox, hormones, or cancer, the score stays low.
11 trials ongoing or recruiting · 57 completed on ClinicalTrials.gov
20 of the completed trials have posted results
Registered trials show research momentum for Calcium-D-Glucarate, not proof of effect — a registration is a plan, and posted results are sponsor-reported, not peer-reviewed. They are never counted toward the evidence rating above.
Browse these trials on ClinicalTrials.govClinicalTrials.gov · as of Oct 2026
Calcium-D-glucarate is the calcium salt of D-glucaric acid. Its rationale rests on inhibiting beta-glucuronidase — the gut/tissue enzyme that cleaves glucuronide conjugates, effectively 'un-doing' phase-II detoxification and allowing toxins, carcinogens, and estrogens to be reabsorbed rather than excreted.
By lowering beta-glucuronidase, it could in theory enhance clearance of estrogens and xenobiotics. The honest reality: this mechanism is demonstrated almost entirely in cell and rodent studies — there are essentially NO human efficacy trials for hormone balance, detoxification, or cancer prevention.
It's a mechanistically-interesting but clinically-unproven supplement.
Lowers beta-glucuronidase, reducing reabsorption of glucuronidated toxins and estrogens (favoring excretion).
Theoretically supports elimination of conjugated metabolites.
How Calcium-D-Glucarate works — from molecular targets to health outcomes. Click an edge to see supporting research.This visualization is in beta — pathways are being refined and expanded.
Use caution — theoretical effect on drug clearance.
Not studied — avoid.
Beta-glucuronidase inhibition could theoretically alter levels of glucuronidated drugs (e.g. some hormones, NSAIDs) — caution.
Tip: Take with food
Calcium-D-Glucarate has an evidence score of 3/10 — emerging evidence based on 3 indexed studies. A calcium salt of glucaric acid that inhibits beta-glucuronidase (an enzyme that recycles toxins and estrogens back into circulation) — a plausible 'detox/estrogen-clearance' mechanism, but the evidence is essentially all preclinical with NO human efficacy trials. Representative study: PMID 2346674.
Dosing for Calcium-D-Glucarate: No dose is endorsed. No established efficacy or safe dose exists in humans: the cited evidence is two animal studies and a review.
The best time to take Calcium-D-Glucarate is with meals. Take it with food. Taken with meals; note there is no human-trial-validated dose.
No consumer dose of Calcium-D-Glucarate is endorsed, so there is no dose at which it can be called safe. Talk to a healthcare provider before taking it. Reported side effects include mild GI upset. How often they occur is not established for all of them. Use caution if any of these apply to you: Pregnancy/breastfeeding (not studied); May affect glucuronidated-drug clearance.
Smoking status: not checked. AREDS2 Formula: what these mean for you changes depending on whether you smoke or used to, and you have not told us. That check was skipped.
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Reviewed by Dr. Baher Al Hakim · Last reviewed June 2026 · evidence from 3 studies · how we score · editorial policy
This information is for educational purposes only. It is not a substitute for professional medical advice. Always consult a qualified healthcare provider before starting, stopping, or changing any supplement or medication.
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