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Calcium-D-Glucarate
A calcium salt of glucaric acid that inhibits beta-glucuronidase (an enzyme that recycles toxins and estrogens back into circulation) — a plausible 'detox/estrogen-clearance' mechanism, but the evidence is essentially all preclinical with NO human efficacy trials.
What the evidence says
Most Calcium-D-Glucarate studies are mechanism or observational rather than RCTs that measure a clinical effect — keep findings provisional.
Most evidence is from medium-quality studies published 1989–2002.
Based on 3 studies
Confidence
Very low confidenceBy outcome
Only a plausible beta-glucuronidase-inhibition mechanism from animal and review studies supports it; with no human efficacy trials for detox, hormones, or cancer, the score stays low.
10 trials ongoing or recruiting · 57 completed on ClinicalTrials.gov
20 of the completed trials have posted results
Registered trials show research momentum for Calcium-D-Glucarate, not proof of effect — a registration is a plan, and posted results are sponsor-reported, not peer-reviewed. They are never counted toward the evidence rating above.
Browse these trials on ClinicalTrials.govClinicalTrials.gov · as of Sep 2026
Calcium-D-glucarate is the calcium salt of D-glucaric acid. Its rationale rests on inhibiting beta-glucuronidase — the gut/tissue enzyme that cleaves glucuronide conjugates, effectively 'un-doing' phase-II detoxification and allowing toxins, carcinogens, and estrogens to be reabsorbed rather than excreted.
By lowering beta-glucuronidase, it could in theory enhance clearance of estrogens and xenobiotics. The honest reality: this mechanism is demonstrated almost entirely in cell and rodent studies — there are essentially NO human efficacy trials for hormone balance, detoxification, or cancer prevention.
It's a mechanistically-interesting but clinically-unproven supplement.
Lowers beta-glucuronidase, reducing reabsorption of glucuronidated toxins and estrogens (favoring excretion).
Theoretically supports elimination of conjugated metabolites.
How Calcium-D-Glucarate works — from molecular targets to health outcomes. Click an edge to see supporting research.This visualization is in beta — pathways are being refined and expanded.
Use caution — theoretical effect on drug clearance.
Not studied — avoid.
Beta-glucuronidase inhibition could theoretically alter levels of glucuronidated drugs (e.g. some hormones, NSAIDs) — caution.
Tip: Take with food
Calcium-D-Glucarate has an evidence score of 3/10 — emerging evidence based on 3 indexed studies. A calcium salt of glucaric acid that inhibits beta-glucuronidase (an enzyme that recycles toxins and estrogens back into circulation) — a plausible 'detox/estrogen-clearance' mechanism, but the evidence is essentially all preclinical with NO human efficacy trials. Representative study: PMID 2346674.
The commonly studied dose of Calcium-D-Glucarate is Commonly 500-1500mg daily (no established efficacy dose). Individual needs vary — start at the lower end of the range and adjust based on how you respond.
The best time to take Calcium-D-Glucarate is with meals. Take it with food. Taken with meals; note there is no human-trial-validated dose.
Calcium-D-Glucarate is generally safe at recommended doses, with a few precautions worth noting. Reported side effects are uncommon and include mild GI upset. Use caution if any of these apply to you: Pregnancy/breastfeeding (not studied); May affect glucuronidated-drug clearance.
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Reviewed by Dr. Baher Al Hakim · Last reviewed June 2026 · evidence from 3 studies · how we score · editorial policy
This information is for educational purposes only. It is not a substitute for professional medical advice. Always consult a qualified healthcare provider before starting, stopping, or changing any supplement or medication.
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