1Meta-Analysis2024
Wang N, Wu Z, Ren J, Zheng X, Han X · Clin Pharmacokinet (2024)
No plain-language summary recorded for this citation — open the paper to read its abstract.
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164 peer-reviewed studies
What the evidence says
Most Canagliflozin studies are mechanism or observational rather than RCTs that measure a clinical effect — keep findings provisional.
Most evidence is from high-quality meta-analyses and randomised trials published 2014–2026 with a typical study size of 2,573 participants.
Based on 164 studies · 23 meta-analyses · 132 RCTs · 860,331 total participants
Confidence
High confidenceBy outcome
66 studies in the last 5 years · Latest meta-analysis: 2026
Wang N, Wu Z, Ren J, Zheng X, Han X · Clin Pharmacokinet (2024)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Ryan PB, Buse JB, Schuemie MJ, DeFalco F, Yuan Z, Stang PE · Diabetes Obes Metab (2018)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Yang T, Lu M, Ma L, Zhou Y, Cui Y · Eur J Clin Pharmacol (2015)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Felici A · Diabetes Res Clin Pract (2026)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Lo KB, Gul F, Ram P, Kluger AY, Tecson KM, McCullough PA · Cardiorenal Med (2020)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Xiong W, Xiao MY, Zhang M, Chang F · Medicine (Baltimore) (2016)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Khan MS, Usman MS, Siddiqi TJ, Memon MM, Shah SJ, Khan SS · Eur J Prev Cardiol (2019)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Meng Q, Shen Y, Liu D, Jiang F · J Diabetes Investig (2016)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Lin C, Zhu X, Cai X, Yang W, Lv F, Nie L · Cardiovasc Diabetol (2021)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Bundhun PK, Janoo G, Huang F · BMC Pharmacol Toxicol (2017)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Fralick M, Kim SC, Schneeweiss S, Kim D, Redelmeier DA, Patorno E · Ann Intern Med (2019)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Schubert A, Buchholt AT, El Khoury AC, Kamal A, Taieb V · Curr Med Res Opin (2017)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Ruanpeng D, Ungprasert P, Sangtian J, Harindhanavudhi T · Diabetes Metab Res Rev (2017)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Chow W, Miyasato G, Kokkotos FK, Bailey RA, Buysman EK, Henk HJ · Clin Ther (2016)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Li B, Wang Y, Ye Z, Yang H, Cui X, Wang Z · J Pharm Pharm Sci (2018)
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In plain English: The results of each study have a direct effect on clinical care for patients who often present to physicians who are not endocrinologists.
Escudero C et al. · Annals of internal medicine (2026)
In plain English: However, careful drug selection is warranted in diabetic patients at risk for DKA.
Qian J, Xu Y. · Clinical nephrology (2026)
Patel S, Gohel K, Patel BG · Curr Diabetes Rev (2016)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Parveen R, Agarwal NB, Kaushal N, Mali G, Raisuddin S · Expert Opin Pharmacother (2016)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Kluger AY, Tecson KM, Barbin CM, Lee AY, Lerma EV, Rosol ZP · Rev Cardiovasc Med (2018)
No plain-language summary recorded for this citation — open the paper to read its abstract.