1Meta-Analysis2026
AlHabil Y, Saadeddin L, Ishkirat H, Alqam M, Hossoon O, Hameedi S · Clin Ther (2026)
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431 peer-reviewed studies
What the evidence says
Most CBD studies are mechanism or observational rather than RCTs that measure a clinical effect — keep findings provisional.
Most evidence is from high-quality meta-analyses and randomised trials published 1979–2026 with a typical study size of 63 participants.
Based on 431 studies · 55 meta-analyses · 245 RCTs · 55,301 total participants
Confidence
High confidenceBy outcome
15 more outcomes with fewer studies not shown.
288 studies in the last 5 years · Latest meta-analysis: 2026
AlHabil Y, Saadeddin L, Ishkirat H, Alqam M, Hossoon O, Hameedi S · Clin Ther (2026)
Wilson J, Dobson O, Langcake A, Mishra P, Bryant Z, Leung J · Lancet Psychiatry (2026)
Spiga F, Parkhouse T, Tang VM, Savović J, Le Foll B, Nielsen S · Cochrane Database Syst Rev (2025)
Martimbianco ALC, Silva RB, Cruz Latorraca CO, de Toledo IP, Pacheco RL, Colpani V · Epilepsy Res (2025)
Raminelli AO, Simei JLQ, Guimarães FS, Zuardi A, Hallak JEC, Crippa JA · Cannabis Cannabinoid Res (2025)
Queiroz CM, de Oliveira Koren L, da Silva CRP, Ribeiro S, Silva SRB · Prog Brain Res (2025)
da Silva GHS, Barbosa EC, de Lima FR, Barroso DC, Paez LEFE, Guimarães FBM · Sleep Med Rev (2025)
Guerrini R, Chiron C, Vandame D, Linley W, Toward T · Epilepsia Open (2024)
Velayudhan L, Pisani S, Dugonjic M, McGoohan K, Bhattacharyya S · Age Ageing (2024)
Xia D, Zhang P, Chen Y, Liu X, Chen Y · Seizure (2024)
Han K, Wang JY, Wang PY, Peng YC · Psychiatry Res (2024)
Chhabra M, Ben-Eltriki M, Mansell H, Lê ML, Huntsman RJ, Finkelstein Y · JAMA Pediatr (2024)
Tong J, Ji T, Liu T, Liu J, Chen Y, Li Z · Epilepsy Behav (2024)
Jang JH, Jeong JH, Jeong SH · Naunyn Schmiedebergs Arch Pharmacol (2024)
Fazlollahi A, Zahmatyar M, ZareDini M, Golabi B, Nejadghaderi SA, Sullman MJM · JAMA Netw Open (2023)
Kwee CMB, Leen NA, Van der Kamp RC, Van Lissa CJ, Cath DC, Groenink L · Eur Neuropsychopharmacol (2023)
Lattanzi S, Trinka E, Russo E, Del Giovane C, Matricardi S, Meletti S · Drugs (2023)
Belgers V, Röttgering JG, Douw L, Klein M, Ket JCF, van de Ven PM · Cannabis Cannabinoid Res (2023)
Wijnen B, Witlox W, Wolff R, Fayter D, Ramaekers B, Otten T · Pharmacoeconomics (2023)
Lo LA, Christiansen A, Eadie L, Strickland JC, Kim DD, Boivin M · J Intern Med (2023)