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Crn6.0
Cranberry Extract Research
Likely helps
179 peer-reviewed studies
What the evidence says
Likely helps
Cranberry Extract appears to help in 8 of 11 studies with measurable effects — the evidence leans clearly favourable.
Most evidence is from high-quality meta-analyses and randomised trials published 2002–2026 with a typical study size of 80 participants.
Based on 179 studies · 18 meta-analyses · 143 RCTs · 37,522 total participants
Confidence
High confidence
What the studies found
8helped3unclear· 168 more without graded effect data
By outcome
Urinary tract infection
Likely helps93 studies
Glucose & metabolic
Mostly mechanism / observational15 studies
Inflammation
Mostly mechanism / observational12 studies
Women's healthMay help manage menopausal symptoms like hot flashes and mood changes · 4-8 weeks
Mostly mechanism / observational11 studies
Therapeutic & clinical
Mostly mechanism / observational10 studies
Safety profile
Mostly mechanism / observational10 studies
Heart & blood pressure
Mostly mechanism / observational7 studies
Oral & dental health
Mostly mechanism / observational5 studies
Cholesterol & lipids
Mostly mechanism / observational3 studies
Liver health
Mostly mechanism / observational3 studies
Immune supportReduced frequency of recurrent UTIs · Ongoing prevention
These data support the use of cranberry products to reduce the risk of symptomatic, culture-verified UTIs in women with recurrent UTIs, in children, and in people susceptible to UTIs following interventions.
Williams G et al. · Cochrane Database of Systematic Reviews (2023)
Fifth update of the Cochrane review; 50 included studies with 8857 randomised participants.
Cranberry products reduce the risk of symptomatic, culture-verified UTIs in women with recurrent UTIs.
Benefit also seen in children and in people susceptible to UTIs following interventions.
3UTI incidence in susceptible populationsMeta-Analysisn=3,979 · very large study2021
We found that cranberry-based products intake can significantly reduce the incidence of UTIs in susceptible populations (risk ratio (RR) = 0.70; 95% confidence interval(CI): 0.59 ~ 0.83; P<0.01).
Xia JY et al. · PloS one (2021)
Large benefit
← WorseNo effectBetter →
Meta-analysis of 23 trials with 3979 participants.
Cranberry intake significantly reduced UTI incidence in susceptible populations (RR = 0.70; 95% CI: 0.59-0.83; P<0.01).
Risk reduction of 32% in women with recurrent UTIs, 45% in children, and 51% in patients using indwelling catheters.
18Symptomatic UTI recurrenceRCTn=145 · medium study2021
Post-hoc results reveal that this high dose of proanthocyanidins may have a preventive impact on symptomatic urinary tract infection recurrence in women who experienced less than 5 infections per year.
Babar A et al. · BMC urology (2021)
No clear effect
← WorseNo effectBetter →
Randomized, double-blind RCT in 145 healthy women with recurrent UTI over 24 weeks.
High dose (2 x 18.5 mg PACs/day) vs low dose (2 x 1 mg PACs/day).
Non-significant 24% decrease in symptomatic UTIs between groups (incidence rate ratio 0.76, 95% CI 0.51-1.11).
Larger, multicentre randomised controlled trials are required to establish optimal dosing, long-term safety, and therapeutic potential.
Brooks L, Farid AFBA, Poobalan A, Johnstone A, Myint PK. · Nutrients (2026)
Nanocurcumin consistently improved EDSS in relapsing-remitting MS (3 trials, n = 150; p = 0.039-0.041), while epigallocatechin-3-gallate, silymarin (SM), cranberry extract, and bio-enhanced curcumin extract (BCM-95) curcumin showed no significant impact on disability, relapse rates, or MRI outcomes.
Meta-analysis was not possible due to the heterogeneity of included studies.
Conclusions : Nanocurcumin may contribute to improvements in disability outcomes in Relapse Remitting Multiple Sclerosis (RRMS), whereas other polyphenols lack consistent efficacy.