37 peer-reviewed studies · Evidence score: 7.5/10
Jepson RG et al. • Cochrane Database of Systematic Reviews (2012)
Cranberry products reduced UTI risk in women with recurrent UTIs.
Long Z et al. • Frontiers in immunology (2023)
Dietary polyphenols may improve DAS28, reduce C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR), and improve oxidative stress, etc.
Nguyen PY et al. • BJOG : an international journal of obstetrics and gynaecology (2025)
ECGC and resveratrol supplements have been investigated for potential effects in managing clinical signs and symptoms of preeclampsia; however, evidence on the clinical and adverse effects of polyphenols is limited and uncertain.
Castellanos JS et al. • BMC oral health (2024)
The overall results showed that the extracts of cranberry and grape seed were effective in reducing the virulence factors of the oral pathogen.
Turk MA et al. • Autoimmunity reviews (2023)
Some non-pharmacological therapies may modestly improve some clinical outcomes in patients with rheumatoid arthritis.
Monici Silva I et al. • European journal of oral sciences (2024)
Only naringin, quercetin, proanthocyanidins, and glutaraldehyde showed statistically significant efficacy over untreated controls.
Gallien P et al. • Multiple sclerosis (Houndmills, Basingstoke, England) (2014)
Taking cranberry extract versus placebo twice a day did not prevent UTI occurrence in MS patients with urinary disorders.
Bansal K et al. • European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry (2024)
The study demonstrated that the cranberry mouth rinse was non-inferior to the fluoride mouth rinse in terms of S. mutans levels change.
Hormoznejad R et al. • International journal of food sciences and nutrition (2020)
It seems that 288 mg of cranberry extract might improve managing NAFLD, which is equivalent to 26 g of dried cranberry.
Olczak-Kowalczyk D et al. • Dental and medical problems (2025)
A daily intake of a tablet containing a paraprobiotic and the cranberry extract reduced the 9-month incidence of initial non-cavitated carious lesions in caries-active preschool children.
Occhipinti A et al. • Urology journal (2016)
Careful determination of the total PAC content using the BL-DMAC method and the authentication of PACs-A with mass spectrometry in cranberry extracts are necessary to prepare effective doses for UTI prevention.
Rondanelli M et al. • Nutrients (2024)
In conclusion, highly standardized cranberry extract phytosome supplementation reduced UTI recurrence.
Koradia P et al. • Expert review of anti-infective therapy (2019)
These findings support the need for further well-designed trials to clarify the benefits that may be achieved.
Laky B et al. • Journal of periodontology (2024)
Multinutrient supplementation as an adjunct to nonsurgical treatment of periodontitis showed some additional benefit regarding probing-pocket-depth and bleeding-on-probing.
Güven O et al. • Revista da Associacao Medica Brasileira (1992) (2023)
Considering the results of this study, it was determined that the patient's complaints decreased from day 3 and their well-being increased with the use of cranberry only.
Asma B et al. • BMC urology (2018)
Clinicaltrials.gov, identifier: NCT02572895 October 8th 2015.
Singh I et al. • International urology and nephrology (2016)
The overall efficacy and tolerability of standardized cranberry extract containing (PAC-A) as a food supplement were superior to placebo in terms of reduced bacterial adhesion; bacterial MRHA negativity; urine pH reduction; and in preventing r-UTI (dysuria, bacteriuria and pyuria).
Skarpańska-Stejnborn A et al. • Journal of the International Society of Sports Nutrition (2017)
Supplementation with cranberry extract contributed to a significant strengthening of antioxidant potential in individuals exposed to strenuous physical exercise.
Ledda A et al. • European review for medical and pharmacological sciences (2015)
These preliminary results, obtained in a field-practice setting, indicates the effectiveness and safety of a well-standardized cranberry extract in the prevention of R-UTI.
Teixeira KTR et al. • Clinical nutrition ESPEN (2022)
Cranberry dry extract supplementation for two months did not reduce the LPS and uremic toxins plasma levels produced by the gut microbiota in non-dialysis CKD patients.